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NCT ID: NCT06116500 Active, not recruiting - Clinical trials for Class II Malocclusion

Effectiveness of Modified Functional Appliance With Expander

Start date: May 9, 2023
Phase: N/A
Study type: Interventional

This clinical trial compares the effectiveness of a myofunctional appliance that uses a clear and modified twin block appliance with an expander made from 2mm biocompatible polyethylene terephthalate modified with Glycol thermoplastic material with a conventional twin block appliance with an expander. The trial will be conducted on adolescent patients with class II division 1.

NCT ID: NCT06027931 Active, not recruiting - Clinical trials for Root Canal Infection

Traditional Versus Conservative Access Cavities Cleaning Ability

Start date: September 12, 2022
Phase: N/A
Study type: Interventional

Aims of the study: 1. Assess the clinical and radiographical outcomes (success/failure) of root canal treatments performed after traditional vs conservative access cavities in permanent posterior teeth after one-year follow-up. 2. Assess the level of disinfection in root canals accessed by traditional vs conservative access cavities in permanent posterior teeth before obturation. Null hypothesis: 1. There is no difference in the clinical and radiographical outcomes of root canal treatments performed after traditional and conservative access cavities preparation in posterior teeth after one-year of follow-up.

NCT ID: NCT06002646 Active, not recruiting - Clinical trials for Pulp Disease, Dental

Lasers as an Alternative to Formocresol and Sodium Hypochlorite Medicaments in Pulpotomy Techniques

Start date: January 4, 2023
Phase: Phase 4
Study type: Interventional

The goal of this clinical trial is to evaluate the dental lasers as an alternative of chemical medicaments used in the pulpotomy procedures. The main question it aims to answer is: • Lasers pulpotomies are a viable alternative to the standard Formocresol and Sodium Hypochlorite medicaments. All participants groups (Formocresol, Sodium Hypochlorite, Diode and Er:Cr;YSGG lasers) for pulpotomy procedure will follow the same clinical protocol, except for the techniques that will be used for hemostasis of the pulpotomies which either will be achieved by Formocresol or Sodium Hypochlorite solutions or by Diode or Erbium lasers.

NCT ID: NCT05995067 Active, not recruiting - Clinical trials for Epithelial Mesenchymal Transition

The Potential Association of Long Non-coding RNA (NEAT1 and MALAT1) in the Process of Epithelial-mesenchymal Transition in Periodontitis

Start date: February 14, 2022
Phase:
Study type: Observational

Periodontitis is a polymicrobial, inflammatory condition affecting tooth-supporting tissues. It is characterized by a progressive loss of epithelial attachment and resorption of alveolar bone, which can lead to tooth loss. Epithelial-mesenchymal transition (EMT) has been proposed as a reversible process that shifts the cell phenotype from epithelial to mesenchymal-like and may be involved in the process of periodontal inflammation either completely or partially. Long non-coding RNAs (lncRNAs) are a large class of regulatory transcripts longer than 200 nucleotides lacking evident protein-coding potential. Studies have shown that lncRNA dysregulation plays key roles in human diseases, including cancer, by modulating the epithelial-mesenchymal transition (EMT). The involvement of lncRNAs markers in the pathogenesis of periodontal disease induced EMT has not been studied thoroughly and have created a gap in the knowledge.

NCT ID: NCT05960916 Active, not recruiting - Clinical trials for Edentulous Alveolar Ridge

Primary Stability of Immediate Implant Using Versah Versus Conventional Burs

Start date: January 22, 2022
Phase: N/A
Study type: Interventional

This study is designed as a Prospective Randomized Clinical Trail, Evaluate the effect of osseodensification technique on primary stability in comparison to the conventional drilling technique in immediate single fresh extraction sockets.

NCT ID: NCT05951907 Active, not recruiting - Anesthesia, Local Clinical Trials

The Anesthetic Efficacy of Lidocaine and Articaine as Buccal Injection for Maxillary Premolar Teeth Extraction.

Start date: January 5, 2022
Phase: N/A
Study type: Interventional

This study Is designed as a prospective randomized, single-blinded clinical trial. To evaluate The anesthetic efficacy of articaine as a buccal Injection for maxillary premolar teeth extraction, compared to lidocaine as a buccal and palatal injection.

NCT ID: NCT05940701 Active, not recruiting - Clinical trials for Enamel Hypomineralization, Dental

The Effectiveness of Biomimetic Materials in Preventing Enamel Demineralization During Fixed Orthodontic Treatment

Start date: January 15, 2023
Phase: N/A
Study type: Interventional

This study will be done to evaluate the impact of Biosmalto Impact Action Mousse™ on the development and healing of WSLs in individuals receiving orthodontic treatment. The control group received a fluoridated toothpaste (Colgate toothpaste). The intervention group received Curasept toothpaste and additionally at each visit a Curasept Biosmalto Mousse was applied on the facial surface of the maxillary and mandibular anterior teeth using a tray. For each patient recruited, identical toothbrushes and oral care instructions were given. The patients received instructions to brush their teeth for at least two minutes using an up-down motion on their anterior teeth and a circular motion on their posterior teeth at least three times/day.

NCT ID: NCT05929391 Active, not recruiting - Clinical trials for Orthodontic Appliance Complication

Effectiveness of Methods to Remove Residual Orthodontic Adhevsie

Start date: May 1, 2023
Phase: N/A
Study type: Interventional

The aim of this study is to compare the clinical efficacy of different residual orthodontic adhesive removing methods for rebonding debonded metal attachments.

NCT ID: NCT05812391 Active, not recruiting - Clinical trials for Periodontal Diseases

Impact of Full Mouth Erythritol Powder Air Polishing on Systemic Inflammatory Response

Start date: March 10, 2023
Phase: N/A
Study type: Interventional

Periodontitis (PD) is an inflammatory condition that affects 20%-50% of the total global population, with severe disease occurring in 9.8% of individuals. clinically characterized by clinical attachment loss (CAL) and bleeding on probing (BOP) accompanied by increased probing pocket depth (PPD) and/or gingival recession, it may end with tooth loss if left untreated. non-surgical periodontal treatment (NSPT) represents the first line of treatment and involves the physical debridement of subgingival plaque biofilms. "full-mouth debridement" (FMD) approach, its NSPT delivers complete debridement within 24 hr. However, full-mouth NSPT has been consistently shown to trigger a large systemic inflammatory response 24 hr following treatment. Nevertheless, Interestingly, a positive correlation between treatment time and the subsequent systemic inflammatory response has been reported. Given this previous link and the different features of each instrumentation technique including air-polishing devices (APDs), that have less time-consuming treatment, reduce patient discomfort and sensitivity, and only minor alterations to surrounding soft and hard tissues. This study aims to evaluate the systemic inflammatory response following full-mouth erythritol powder air polishing and instrumentation.

NCT ID: NCT05798871 Active, not recruiting - Clinical trials for Periodontal Diseases

Efficacy of Subgingival Erythritol Air Polishing in Treatment of Periodontal Pockets

Start date: March 5, 2023
Phase: N/A
Study type: Interventional

Periodontitis is an inflammation associated with destruction of the periodontium that ultimately, if not treated, leads to tooth loss. Clinically, it is characterized by clinical attachment loss (CAL) and bleeding on probing (BOP) accompanied by increased probing pocket depth (PPD) and/or gingival recession. The standard periodontitis treatment aims to restore the homeostasis of the immune system by mechanically reducing the microbial load to levels that are compatible with stability and health. This is achieved by professional mechanical biofilm control and motivation of the patient for oral hygiene measures in order to control the biofilm and avoid disease recurrence. Conventional scaling and root planing (SRP), and air polishing therapy are tools used for professional biofilm control. More recently, air-polishing devices have become a promising alternative to conventional SRP in reducing the clinical time and causing less discomfort and pain for the patients. The objective of this study is to evaluate the efficacy of subgingival erythritol air polishing for initial periodontal pocket healing.