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NCT ID: NCT05427643 Active, not recruiting - Clinical trials for Dental Implantation, Endosseous

Evaluation of the Effect of Injectable Platelet Rich Fibrin on Stability of Dental Implant for Narrow Ridges

Start date: December 15, 2021
Phase: N/A
Study type: Interventional

the main aim of the study is to evaluate the secondary implant stability when using dental implants with injectable platelet rich fibrin accompanied by non-autogenous bone graft material in narrow ridge cases versus straightforward ridges , in clinical comparative study.

NCT ID: NCT05419687 Not yet recruiting - Workplace Violence Clinical Trials

Violence Against Health Care Workers in Fragile Settings

VIA-H
Start date: August 2022
Phase: N/A
Study type: Interventional

The general objective of the project is to assess whether a violence de-escalating training for health professionals and of a publicly displayed Code of Conduct (a set of rules developed through a citizen science and co-design approach) for both health professionals and clients at the level of the health facility, can reduce the incidence and severity of episodes of violence, and to identify the most cost-effective way to implement these interventions in rural Democratic Republic of Congo (DRC) and in the mega city of Baghdad, Iraq.

NCT ID: NCT05403164 Recruiting - Periodontitis Clinical Trials

Epithelial Mesenchymal Transition and Periodontitis

Start date: July 12, 2021
Phase:
Study type: Observational

Periodontitis is a chronic inflammatory disease results is destruction of the attachment apparatus of the teeth and ultimately tooth loss. Epithelial-mesenchymal transition (EMT) is a process comprises of series of events that influence a polarized epithelial cell to undergo molecular/morphological changes leading to acquisition of mesenchymal cell phenotype. This process is responsible for suppressing epithelial-phenotype and it is known to be triggered by chronic exposure to inflammatory cytokines, Gram-negative bacteria, hypoxia, smoking, and hyperglycemia. Both periodontitis and EMT share common risk factors/promoters; however, the role of EMT in the pathogenesis of periodontitis is not fully elucidated yet. Potential induction of EMT within periodontal pockets may disrupt epithelial barrier thus facilitating invasion of pathogenic periodontal pathogens to deeper tissues resulting in further tissue breakdown and non-resolving periodontal lesion.

NCT ID: NCT05398874 Recruiting - Knee Osteoarthritis Clinical Trials

Clinical Efficacy of Ginkgo Biloba Extract in the Treatment of Knee Osteoarthritis

Start date: November 1, 2021
Phase: N/A
Study type: Interventional

To assess the efficacy and safety of the Ginkgo biloba extract in patients with Knee OA.

NCT ID: NCT05391542 Recruiting - Aligning Archwires Clinical Trials

Effectiveness of Tubular Coaxial Nickel-titanium and Copper Nickel-titanium Orthodontic Aligning Archwires

Start date: February 28, 2022
Phase: N/A
Study type: Interventional

This study will be done to compare the effectiveness of using coaxial tubular superelastic nickel-titanium and copper-nickel-titanium archwires during the initial phase of orthodontic treatment regarding alignment efficiency, pain perception, and root resorption.

NCT ID: NCT05391386 Recruiting - Molar Tube Bonding Clinical Trials

Evaluation of Failure Rate of Molar Tube With a Modified Bonding Technique

Start date: January 15, 2022
Phase: N/A
Study type: Interventional

Comparing between the failure rates of molar tubes bonded with conventional bonding technique using resin adhesive and the alternative bonding technique using compomer (containing glass ionomer) adhesive by adding a layer of compomer adhesive at the molar/tube interface.

NCT ID: NCT05390996 Active, not recruiting - Clinical trials for Dental Implant Stability

Implant Stability Changes In Dental Implants Installed By Osseodensification and Conventional Methods

Start date: January 5, 2022
Phase: N/A
Study type: Interventional

The aim of this study is to evaluate the effect of Osseodensification on implant stability during the healing period The objective of this study is to compare between dental implant stability after osteotomy site preparation using osseodensification technique and conventional drilling technique immediately after implant installation (primary stability) , 6 week after the insertion of implant and 12 weeks later (secondary stability)

NCT ID: NCT05389059 Enrolling by invitation - Gingival Diseases Clinical Trials

Injectable Platelet Rich Fibrin With Collagen Matrix in Treatment of Multiple Gingival Recession.

Start date: April 25, 2022
Phase: N/A
Study type: Interventional

This study is proposing the use of i-PRF clot as a scaffold for the XCM in order to obtain a novel biomaterial, incorporating active growth factors and collagen matrix in a single framework, based on the potential effect of i-PRF to enhance fibroblast activity and angiogenesis stimulation for treatment of multiple gingival recession.

NCT ID: NCT05379049 Recruiting - Clinical trials for Rheumatoid Arthritis

Therapeutic Response to Tumor Necrosis Factor-alpha (TNF-alpha) Antagonists in Rheumatoid Arthritis.

TNF-alpha
Start date: March 1, 2022
Phase:
Study type: Observational

Rheumatoid arthritis (RA) is an autoimmune, chronic inflammatory disease and TNF-alpha has been recognized as a triggering cytokine in the induction of joints inflammation and is involved in the pathogenesis of RA. Treatment for RA aims to reduce disease activity, prevent or manage joint deterioration and lower the risk of major comorbidities such as heart disease and stroke. The strategy of targeting cytokines has significantly increased RA patient outcomes. Therefore management with biological disease-modifying antirheumatic drugs "bDMARD" (Etanercept, Infliximab, Adalimumab) should be considered, If the treatment goal is not met with the first conventional synthetic drug modifying antirheumatic drugs (csDMARD) strategy, or if there are poor prognostic factors. The multi-biomarker disease activity test could be used to help standardise individual treatment decisions, especially in patients who failed to respond well to the traditional treatment. Iraq does not currently have specific guidelines, which might pose a risk to patients' safety. More data about the choice of bDMARD is needed in terms of tracking therapeutic response, or whether TNF or other pro-inflammatory cytokines like interleukin-6 (IL-6) is the main factor for the development and severity of RA. These data are important to improve the overall status of the patient, better choice of treatment and biomarkers to detect. There is limited information on the treatment patterns of rheumatoid arthritis (RA) across Iraq including the Kurdistan Region. Therefore, the aim of this research is to evaluate the efficacy, and clinical responses of RA patients who have been treated with different anti-TNF, as well as on answering the research hypothesis, Can plasma TNF-alpha and IL-6 be used as markers of therapeutic response to TNF alpha antagonist in patients with RA?

NCT ID: NCT05371691 Recruiting - Clinical trials for Tooth Position Anomalies

The Effectiveness of Myofunctional Appliances.

Start date: September 10, 2021
Phase: N/A
Study type: Interventional

A randomized clinical trial is set out to compare the effectiveness of two types of functional appliances in the correction of a Class II malocclusion. (Class II malocclusions are where upper front teeth bite significantly further forward in relation to lower front teeth).