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NCT ID: NCT05172947 Recruiting - Clinical trials for Diabetic Neuropathies

Effect of Resveratrol and Pharmacist Intervention on Diabetes Mellitus and Its Neuropathic Complication

Start date: December 5, 2021
Phase: N/A
Study type: Interventional

Management of symptoms associated with diabetic neuropathy is a difficult issue for clinicians since it usually does not respond to standard analgesics. Resveratrol is a naturally occurring plant-derived, polyphenolic compound, it exerts pleiotropic activity. The investigators believed that the implementation of multidisciplinary approaches including pharmacotherapy and provision of healthcare professional services such as pharmacist intervention are needed for alleviation of diabetic associated neuropathy.Therefore, the hypothesis of the present protocol is that the administration of resveratrol and/or provision of pharmaceutical care in patients with diabetic neuropathy might be of value in improving quality of life and managing diabetic neuropathic pain.The study is designed as a four-arm randomized, placebo-controlled clinical trial. Group one will be given only conventional hypoglycemic drugs. Group two patients will receive conventional hypoglycemic drugs accompanied by pharmacist interventions. Group three; patients will receive resveratrol 500 mg orally once daily after meals for three months, in addition to their regular hypoglycemic drugs. Group four; patients will receive resveratrol 500 mg orally once daily after meals along with their regular hypoglycemic drugs for a period of three months, accompanied by pharmacist interventions. Neuropathic pain will be measured by various neuropathic pain assessment tools. Nerve conduction studies will be performed to assess the effect of interventional therapy. The expected outcome will be the improvement of diabetic neuropathy associated symptoms along with glycemic status.

NCT ID: NCT05162417 Recruiting - Clinical trials for Periodontal Diseases

Photodynamic in Periodontal Treatment

Start date: November 15, 2021
Phase: N/A
Study type: Interventional

Dental biofilm is a primary etiological factor for periodontal diseases.(1) The bacterial biofilm would induce recruitment of leucocytes, neutrophils, and T lymphocytes and the secretion of antibodies, lipopolysaccharides, and chemical inflammatory mediators such as cytokines and chemokines.(2) Thus, periodontal diseases can cause tissue destruction and results in deterioration of clinical parameters measures such as periodontal pockets depth, clinical attachment loss, bleeding on probing, bone destruction, and resulting ultimately in tooth loss.(3)

NCT ID: NCT05151614 Completed - COVID-19 Pandemic Clinical Trials

Adjuvant Use Of Colchicine With The Standard Therapy In Moderate And Severe Corona Virus Disease-19 Infection

Start date: April 1, 2021
Phase: Phase 1
Study type: Interventional

The study included 2 arms Colchicine group: Colchicine + standard therapy of COVID-19 Control group: Standard therapy of COVID-19

NCT ID: NCT05052333 Not yet recruiting - Covid19 Clinical Trials

Examine the Psychosocial Impacts of Covid-19 Pandemic.

Start date: January 1, 2022
Phase:
Study type: Observational

This is an observational study examining the psychosocial impacts of the COVID-19 pandemic in several low-resource countries (Pakistan, Bangladesh, Iraq, Somalia, Indonesia, Malaysia, Turkey) and an English-speaking country (USA). The data will be obtained on the measures of wellbeing (WHO Well-Being Index), psychological distress (Kessler 10), post-traumatic stress (PTSD Checklist for DSM-5), post-traumatic growth (Posttraumatic Growth Inventory), and pandemic-related stress (Covid Psychosocial Impacts Scale). Depending on the context, the data will be collected employing either a unilingual (in native language) or bilingual online survey (with English as a second language) from 500 participants (aged 18 and above) in each of the eight locations using non-probability convenient sampling. Where applicable in some countries (Malaysia, Turkey, and Somalia), a follow-up survey will be repeated in the same cohort, which will provide a comparable data set longitudinally. The findings will enable us to examine the psychosocial impacts of COVID-19; validate the translations of the CPIS and standardized measures; and determine the trajectory of study variables with pandemic exposure.

NCT ID: NCT05051709 Recruiting - Hallux Valgus Clinical Trials

Can Hypermobility of First Ray Affect Surgical Treatment of Hallux Valgus

Start date: September 15, 2021
Phase: N/A
Study type: Interventional

Hallux valgus can be associated with hypermobility of 1st ray. Surgical decision for hallux valgus can be affected by hyper mobility of 1st ray so our clinical trial involved patients with bilateral hallux valgus were planned to underwent fusion of 1st ray and soft tissue correction plus bonionectomy for one foot and for other foot surgical treatment involves corrective osteotomy and soft tissue procedure plus bonionectomy without fusion of 1st tarsometatarsal joint.

NCT ID: NCT05046977 Recruiting - Pyle Disease Clinical Trials

Double Osteotomy for Deformity Correction in Pyle Disease

Start date: September 20, 2021
Phase: N/A
Study type: Interventional

Leg deformity is one of the features of Pyle disease( metaphyseal dysplasia). Correction of valgus deformity of the leg can be done after deformity analysis by double osteotomy so this study showed how double osteotomy can lead to better results than single osteotomy.

NCT ID: NCT05017493 Completed - Covid19 Clinical Trials

Treatment of Covid-19 With a Herbal Compound, Xagrotin

Start date: July 1, 2020
Phase: Phase 1/Phase 2
Study type: Interventional

This is an interventional, multi-center, randomized study. Adults with confirmed covid-19 disease not more than 10 days before enrollment date were recruited (n=361). Patients in same condition who had treated with standard of care were randomly assigned to the control group (n=178). The investigators analyzed the effect of a herbal compound, Xagrotin, and also investigated impact of different characteristics for instance gender, age, duration of disease, smoking habits and concomitant diseases on the outcome.

NCT ID: NCT05006014 Recruiting - Clinical trials for Maintain the Esthetic

Immediate Implant With Provisionalization

Start date: January 27, 2021
Phase:
Study type: Observational [Patient Registry]

Prospective observational clinical study conducted to evaluate the success of graftless immediate implantation with provisionalizaion

NCT ID: NCT05005806 Recruiting - Sjogren's Syndrome Clinical Trials

Fish Oil (Omega 3 ) in Sjogren's Syndrome

Start date: September 2, 2021
Phase: Phase 2/Phase 3
Study type: Interventional

Sjögren's syndrome (pSS) is an autoimmune disorder affecting mainly the exocrine glands.this lead to dryness of the main mucosal surface ,such as the mouth ,eye,skin nose,pharynx,larynx and vagina . The history of the disease is characterized by a slowly progression of sicca symptoms and fatigue; however, a subset of patients would experience extra glandular activity. Lipid mediators derived from polyunsaturated fatty acids, related to inflammation and immune response regulation. In this sense, the polyunsaturated fatty acids omega-3 (ω-3 FA) have been associated with several illnesses such as cancer, cardiovascular disease and autoimmune diseases and their balance at the cellular membranes can result in an anti-inflammatory .

NCT ID: NCT04998929 Completed - Navel; Hernia Clinical Trials

A Common But Unknown Disease; Nave Sliding (NS)

NS
Start date: August 1, 2020
Phase:
Study type: Observational

The present study is a case series study, conducted to introduce a common disease of abdominal wall which has received less attention in scientific resources. The study population was all patients who following repeated hospital visits did not improve, and for their last try, they visited a traditional clinic, and were diagnosed with umbilical hernia.