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NCT ID: NCT04098562 Not yet recruiting - Diabetic Foot Ulcer Clinical Trials

Efficacy of LL-37 Cream on Bacteria Colonization, Inflammation Response and Healing Rate of Diabetic Foot Ulcers

Start date: October 2019
Phase: Phase 2
Study type: Interventional

Diabetic foot ulcer (DFU) is a common complication of diabetes with global prevalence of 6.3%. Treatment of diabetic foot ulcer (DFU) is challenging with disappointing outcome. Wound debridement, infection control, pressure relief and revascularization are main pillars of DFU management. Various substances and modalities are being investigated for their potential effects in treating DFU, one of which is LL-37. In this randomized, controlled trial, 40 patients with uncomplicated DFU will be enrolled. Patients are randomly assigned to undergo twice a week treatment with 0.5 mg/mL LL-37 cream (treatment group) or placebo cream (control group) for 4 weeks in addition to standard wound care. The primary outcomes are the healing rate measured by wound area and granulation index and changes in patterns of aerobic bacteria colonization during the 4-week study duration and changes in concentrations of IL-α and TNF-α from fluid collected from DFU on the end of the second and third week of study compared to baseline.

NCT ID: NCT04036825 Not yet recruiting - Malnutrition Clinical Trials

Liquid Nutritional Supplement on Malnutrition Hospitalized Patient

Start date: August 2019
Phase: N/A
Study type: Interventional

The aim of this study is to know the effectivity of liquid nutritional supplementation in malnutrition hospitalized patients

NCT ID: NCT04029649 Not yet recruiting - Ulcerative Colitis Clinical Trials

Beta-1,3/1,6-D-Glucan Ganoderma Lucidum on Ulcerative Colitis

Start date: August 2019
Phase: Phase 2/Phase 3
Study type: Interventional

The aim of this study is to determine the efficacy and safety of Beta-1,3/1,6-D-Glucan from mycelium extract of Ganoderma lucidum on ulcerative colitis

NCT ID: NCT04011969 Not yet recruiting - Colorectal Cancer Clinical Trials

The Role of Gut Microbiome and Chronic Inflammation in Young-onset Colorectal Cancer

Start date: July 2019
Phase:
Study type: Observational

This study aims to investigate the role of gut microbiome pattern and inflammation marker NF-ҡB in young-onset colorectal cancer

NCT ID: NCT03899454 Not yet recruiting - Oxidative Stress Clinical Trials

Garcinia Mangostana L Rind and Solanum Lycopersicum Fructus Trial to Prevent Exercise-induced Oxidative Stress

GMR-RCT-EOS
Start date: July 15, 2020
Phase: Phase 2/Phase 3
Study type: Interventional

Treatments are an administration of a mixed extract of Garcinia mangostana 400mg and Solanum Lycopersicum Fructus 200mg (OKSI(R) POM TR 193324351) and placebo control.

NCT ID: NCT01840384 Not yet recruiting - Clinical trials for Anemia, Iron-deficiency

Efficacy Study of Multiple Micro Nutrients Supplementation

Babytop
Start date: July 2013
Phase: N/A
Study type: Interventional

This study is initiated to investigate the effect of multi micronutrient supplementation for 12 months on serum haemoglobin level in Indonesian young children.

NCT ID: NCT01725698 Not yet recruiting - Union Clinical Trials

The Combined Effect of Mesenchymal Stem Cell, HA-CaSO4,BMP-2, and Implant in Inducing The Healing of Critical-Sized Bone Defect

Start date: November 2012
Phase: Phase 1
Study type: Interventional

This research is aimed to evaluate the combination of mesenchymal stem cell, HA-CaSO4, BMP-2, and implant in treating critical-sized bone defect. In the presence of critical-sized bone defect whose defect size is more than 2.5 cm, bone will suffer a healing disturbance. In treating these conditions, the conventional method were vascularised bone grafting and bone transport. But the existing methods of treatment have many weaknesses Vascularized bone graft is a procedure with a high level of difficulty. Hence not every orthopaedic surgeon were able to perform it. It also takes more operating time and its failure rate is also quite high. Meanwhile, external fixation which is applied with bone transport, was being often complained by the patient in terms of cosmetic and psychologically. According to diamond concept of bone healing, there are four main factors that influence the bone healing. These factors are osteogenic factor (mesenchymal stem cell), osteconductive factor (HA-CaSO4), osteoinductive factor (bone morphogenetic protein-2) and mechanical component (implant). The potency of each component in fracture healing with/out bone defect has been proved in many studies. The combined effect of these components is often studied as well, but not in critical-sized bone defect.