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NCT ID: NCT05703438 Completed - Clinical trials for Metabolic Syndrome, Protection Against

The Effect of a Low-calorie Diet With Balanced Nutrition to Metabolic Syndrome

Start date: August 5, 2022
Phase: N/A
Study type: Interventional

The study examined the effect of a nutritionally balanced low-calorie diet based on the archipelago diet on metabolic biomarkers of health workers suffering from obesity. The archipelago diet given is the food of the Minangkabau people. Metabolic biomarkers assessed include body mass index, waist circumference, blood pressure, body fat mass percentage, fasting blood sugar levels and lipid profiles. Researchers hypothesize the provision of a balanced nutrition low-calorie diet based on an archipelago diet will have a significant effect on the metabolic biomarkers of health workers suffering from obesity.

NCT ID: NCT05697614 Recruiting - Clinical trials for Drug Resistant Epilepsy

The Benefit and Safety of Older Generation Anti-Epileptic Drugs (AEDs) in Drug-Resistant Epilepsy Children

Start date: March 1, 2023
Phase: Phase 4
Study type: Interventional

The goal of this interventional study is to learn about the efficacy and safety of first line anti epileptic drugs (AEDs) as substitution therapy for children who are resistant to second-line AEDs. The main question to answer it aims are : how much the difference proportion of responders (responders are children who achieve the decrease of seizure frequencies by 50%) how much time it is needed to achieve the decrease of seizure frequencies by 50% The patients who are eligible for the study and have given their consent, will be enrolled, divided into 2 groups, the control and intervention. The participant should follow the 14 weeks of intervention that consists of 6 phases : baseline, initial dose, titration dose, maintenance dose, tapering-off dose, and new combination maintenance dose.

NCT ID: NCT05697601 Not yet recruiting - Ovarian Cancer Clinical Trials

Predictors of Ovarian Cancer and Endometrial Cancer for Artificial-Intelligence-Based Screening Tools

Start date: February 28, 2023
Study type: Observational

The goal of this observational study is to explore the possible associated factors of ovarian cancer and endometrial cancer in Indonesia and develop screening tools that could predict the risk of both types of cancer The specific objectives of the study are 1. Elaborating the situation of ovarian and endometrial cancer in Indonesia 2. Exploring the possible clinical, demography and laboratory predictors of these diseases 3. Develop artificial-intelligence-based screening tools for both type of cancer based on possible predictors This study will utilize the patient registry diagnosed with ovarian and endometrial cancer. We assumed that several demography, clinical, and laboratory predictors might possess good screening performance with higher sensitivity and specificity (>80%).

NCT ID: NCT05691764 Completed - Cardiac Surgery Clinical Trials

Effect of Cyclosporine and Remote Ischemic Preconditioning in Reperfusion Ischemia Injury on Tetralogy Fallot Patients With Correction Surgery

Start date: September 1, 2020
Phase: N/A
Study type: Interventional

The study aimed to evaluate the combined effects of cyclosporine and remote ischemic preconditioning on MDA, calcium cytosol concentration, and mitochondrial edema in tetralogy Fallot patients undergoing corrective surgery.

NCT ID: NCT05688722 Completed - Surgery Clinical Trials

Head Elevation During Pre-oxygenation Can Delay Desaturation Time

Start date: April 1, 2021
Phase: N/A
Study type: Interventional

This study is a randomized-controlled trial study comparing the association between several degree of head elevation and conventional position during pre-oxygenation to desaturation time in patients undergo endotracheal intubation with general anesthesia

NCT ID: NCT05685017 Completed - Obesity Clinical Trials

Adiponectin, ICAM-1, VCAM-1 Levels and Metabolic Syndrome in Obese Adolescents

Start date: October 1, 2019
Study type: Observational [Patient Registry]

Adipose tissue secreting a number of adipokines which regulate insulin sensitivity, energy metabolism and vascular homeostasis, so the dysfunction of adipose tissue is linked with the incidence of obesity accompanied with insulin resistance, hypertension and cardiovascular disease (1). Obesity is known to alters the expression of adipokines due to the adipose tissue hypertrophy (2), including adiponectin, in which able to exert a potent anti-inflammatory and vascular protective effect (2). It has been proposed that adiponectin acts to prevent the vascular dysfunction due to obesity and diabetes by improves insulin sensitivity and metabolic profiles to reduce the risk factors for cardiovascular disease and protects the vasculature through its pleiotropic actions on endothelial cells, endothelial progenitor cells, smooth muscle cells and macrophages (1). The concentrations of adiponectin of 5 to 25 mg/mL had a significant inhibitory effect on the expression of monocyte adhesion and adhesion molecule induced by TNF-α in vitro. Atherosclerosis is an inflammatory disease in which adhesion molecules on arterial endothelial cells are responsible for the accumulation of monocytes/macrophages and T lymphocytes. While obesity is low-grade inflammation in which make a contribution on endothelial dysfunction by increasing the oxygen-derived free radicals (ROS) due to adipocyte hypertrophy, leads to an endoplasmic reticulum (ER) stress and mitochondrial dysfunction (3). Adiponectin is accumulated in the vasculature, and it reduced on obesity due to suppression by TNF-α and lead to adiponectin-deficiency which stimulate the significant increases of Vascular cell adhesion protein 1 (VCAM-1) and Intercellular Adhesion Molecule 1 (ICAM-1) or known as CD54 in aortic intima (4). Here we investigate the level of adiponectin, ICAM-1, VCAM-1 with the incidence of MetS in obese adolescents.

NCT ID: NCT05682885 Recruiting - Clinical trials for Breast Cancer Related Lymphedema

The Effectiveness of Lymphatic Bypass Supermicrosurgery

Start date: October 6, 2022
Phase: N/A
Study type: Interventional

This study evaluate the effectiveness of lymphatic bypass supermicrosurgery (LBS) and axillary lymph node dissection (ALND) compare to ALND alone to prevent breast cancer treatment-related lymphedema (BCRL).

NCT ID: NCT05681897 Recruiting - Clinical trials for Alopecia, Androgenetic

Comparing Platelet-Rich Plasma (PRP) Centrifugation Methods on Thrombocyte Concentration and Clinical Improvement of Androgenetic Alopecia

Start date: February 2023
Phase: N/A
Study type: Interventional

This research is a preliminary, randomized, double blind clinical trial, which will examine the differences in PRP preparation methods, a single-spin centrifugation of 3000 rpm in 15 minutes compared to a double-spin centrifugation of 1500 rpm in 6 minutes followed by 2500 rpm in 15 minutes, on the results of Thrombocyte Concentration and Clinical Improvement of Androgenetic Alopecia.

NCT ID: NCT05670418 Recruiting - Clinical trials for Long COVID-19 Syndrome

Cognitive Function Analysis and qEEG Study in Long COVID-19 Syndrome Patients

Start date: October 1, 2022
Study type: Observational

Over than 30% individuals with COVID-19, including the asymptomatic ones, and around 80% of patients hospitalized with COVID-19 may experience post-COVID sequelae, which is commonly referred to as Long COVID Syndrome. This condition has ties to decreased cognitive function and may lead to neuropsychiatric disorders but still need to be studied further. Using a cross-sectional design, this study will analyze the relationship between cognitive function and neuropsychiatric disorders with brain wave activity in Long COVID patients. The investigators conducted assessments utilizing the quantitative electroencephalogram (qEEG) measurement method and interviews using instruments such as the MMSE MOCA, mini ICD 10, and SF 36. With this qEEG examination, the investigators hoped that there will be an imbalance/abnormality of brain wave activity that arises related to impaired cognitive function.

NCT ID: NCT05665985 Completed - Clinical trials for Rheumatoid Arthritis

Effect Of Moringa Leaf Extract On Disease Activity In Rheumatoid Arthritis Patients

Start date: May 1, 2020
Phase: Phase 1/Phase 2
Study type: Interventional

Intervention therapy study of moringa oliefera extract on the degree of activity of rheumatoid arthritis patients. The research subjects were patients with rheumatoid arthritis-intervention with moringa oliefera for 30 days.