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NCT ID: NCT03635840 Recruiting - Cardiogenic Shock Clinical Trials

The Effects of IABP Prior to Revascularization on Mortality of ACS Patients Complicated With Cardiogenic Shock

Start date: January 4, 2018
Phase: N/A
Study type: Interventional

Prevalence of cardiogenic shock in acute coronary syndrome patients is reported at about 5-8% with high fatality. Revascularization approach has already known as the standard of care, but the usage of intra-aortic balloon pump (IABP) as mechanical circulatory support is still a controversy. IABP SHOCK II trial revealed that short-term mortality did not improved by IABP but there are several essential variabels related to mortality that are not considered in the study which are IABP initiation time and weaning protocol.This study aim to evalute the effect of IABP prior to revascularization on mortality of patients with myocardial infarction complicated with shock. 92 subjects will be enrolled in this randomized controlled trial into two groups, with and without IABP. IABP group will be receiving the intervention prior to revascularization. The primary outcomes to be sought are in-hospital and 30-day mortality after revascularization. IABP effects measured by various indicators such as Global Longitudinal Strain by echocardiography on the 1st and 3rd day, NTproBNP and ST2 level on the 1st, 3rd and 5th day, effective lactate clearance and ureum creatinine level on the 1st and 3rd day and will be compared between two groups. Continous variabel will be presented in mean ± deviation standard or median, and analized with Student's t test or Mann-Whitney U test as appropriate.

NCT ID: NCT03627533 Not yet recruiting - Clinical trials for in Vitro Fertilization

Effects of Electroacupuncture on Granulosa Cell Apoptotic Index,Oocyte Maturation,GDF9 and BMP15 In Vitro Fertilization

Start date: September 1, 2018
Phase: N/A
Study type: Interventional

Interventional studies compared electroacupuncture group versus sham electroacupuncture group to granulosa cell apoptosis index, oocyte maturation, GDF9 and BMP15 levels, and fertilization rate in in vitro fertilization program

NCT ID: NCT03622060 Recruiting - Vasodilation Clinical Trials

Intraarterial Nitroglycerin Versus Nicardipine and Radial Artery Occlusion

NONERAO
Start date: July 6, 2018
Phase: Phase 3
Study type: Interventional

A total of 200 patients undergoing coronary procedures via transradial access with a 6-F sheath will be randomized at the end of the procedure to receive either 250-µg nicardipine or 500-µg nitroglycerin administered to the radial artery through the radial sheath before sheath removal. A continuous patent hemostasis was applied in each patient with the use of an oximetry to maintain an oxygen saturation of >95% and measured in the finger of the accessed arm until compression device was totally removed. The primary outcome is early and late RAO which will be evaluated by color duplex ultrasonography of the accessed arteries at 24 h - 48 h and 30 days after the procedure. Secondary outcome will be the change of blood pressure before and 2-3 minutes after drug administration. Logistic regression was used to find the association between use of vasodilators and RAO.

NCT ID: NCT03621384 Completed - Clinical trials for Diabetic Kidney Disease

Association of BsmI Polymorphisms in Vitamin D Receptor Gene With Diabetic Kidney Disease

Start date: November 2014
Phase:
Study type: Observational

Background: Diabetic kidney disease (DKD), as one of chronic complication of type 2 diabetes mellitus, is common cause of end stage renal disease (ESRD). Vitamin D deficiency is known as one of DKD risk factors. Recent studies on association between vitamin D deficiency and DKD had shown conflicting results. It may be due to vitamin D receptor gene polymorphisms, which is affected by BsmI, Cdx2, ApaI, FokI, and TaqI gene. The investigators conducted cross-sectional study to investigate association between BsmI polymorphisms in vitamin D receptor gene with diabetic kidney disease Hypothesis: BsmI polymorphisms in vitamin D receptor gene is associated with diabetic kidney disease (DKD)

NCT ID: NCT03617068 Completed - Hand Dermatoses Clinical Trials

The Effectiveness of Coconut Oil Cream as a Prevention Treatment for Occupational Hand Dermatitis Among Batik Workers

Start date: February 6, 2017
Phase: Phase 3
Study type: Interventional

Empirically, mosturizer is used to prevent and treat many occupational dermatoses that has skin barrier impairment. Evidence based medicine about the effectivity of mosturizer in occupational dermatoses is limited. Coconut oil is one of traditional substance that is used as a skin care. There is study shows that coconut oil is effective for atopic dermatitis treatment in children. Other studies are needed to assess the effectivity coconut oil mosturizer cream to overcome occupational hand dermatitis.

NCT ID: NCT03607201 Active, not recruiting - Heart Failure Clinical Trials

Acute Coronary Syndrome in Diabetic Patients

Start date: August 1, 2017
Phase:
Study type: Observational

This study aims to compare the clinical profile and outcomes of acute coronary syndrome patients with diabetes and without diabetes.

NCT ID: NCT03596944 Active, not recruiting - Clinical trials for Acute Coronary Syndrome

Primary Prevention With Statin and Incidence of Recurrent MI and Cardiogenic Shock in Post-ACS Patients

Start date: August 1, 2017
Phase:
Study type: Observational

This study aims to evaluate the effect of statin for primary prevention, towards lowering the incidence of recurrent myocardial infarction, cardiogenic shock and mortality in ACS patients.

NCT ID: NCT03596931 Active, not recruiting - Heart Failure Clinical Trials

Prior Statin Use and Risk of CHF, ALO and Malignant Arrhythmia in Indonesian Post-Acute Coronary Syndrome Patients

Start date: August 1, 2017
Phase:
Study type: Observational

This study aims to evaluate the effect of statin for primary prevention, towards lowering the incidence of heart failure, acute lung edema, malignant arrhythmia and death in ACS patients.

NCT ID: NCT03591575 Recruiting - Iron Overload Clinical Trials

Safety and Efficacy of Early Treatment With Deferiprone in Infants and Young Children

START
Start date: August 1, 2018
Phase: Phase 4
Study type: Interventional

This study is looking at the effects of giving early treatment of deferiprone to young children with beta thalassemia who have started receiving regular blood transfusions but have not yet reached the criteria for starting on iron chelation therapy. Half the patients in the study will receive deferiprone, and the other half will receive placebo, for up to 12 months.

NCT ID: NCT03568812 Recruiting - HIV Infections Clinical Trials

The Role of Probiotics in HIV Patients With Immunological Non-Responder

PIONIR
Start date: May 7, 2018
Phase: Phase 2
Study type: Interventional

This study will address HIV patients who are on antiretroviral treatment (ART) and experiencing immunological failure. The cause of immunological failure in HIV patients could be due to several factors such as age, gender, Cluster of Differentiation (CD4)+ count before started treatment and some inflammation in the gut. The C-C Chemokine Receptor 5 (CCR5) receptor on T lymphocyte CD4+ are abundantly found in the gut and attacked by HIV virus during acute infection causing irreversible damage. The disruption of gut integrity and chronic inflammation further causing translocation of bacteria in gut lumen to the blood. Thus resulting persistent low CD4+ or immunological failure. This evaluation plan is designed to establish the role of investigation product (probiotics) to improve gut inflammation in HIV patients.