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NCT ID: NCT03504631 Recruiting - Clinical trials for Breast Cancer Female

Genotyping and Phenotyping of CYP2D6 Breast Cancer Patients on Tamoxifen

Start date: October 1, 2017
Phase:
Study type: Observational

This study is an observational study to determine phenotype and genotype of CYP2D6 as predictors of z-endoxifen concentrations in plasma of outgoing patients treated with tamoxifen for at least 4 months

NCT ID: NCT03503058 Not yet recruiting - Malaria Clinical Trials

Safety, Tolerability, Immunogenicity and Protective Efficacy of PfSPZ Vaccine and PfSPZ-CVac in Indonesian Adults Against Naturally-Transmitted Malaria

Start date: August 2018
Phase: Phase 2
Study type: Interventional

The study is a single site, double-blind, randomized, placebo-controlled clinical trial that will assess the safety, tolerability, immunogenicity and vaccine efficacy (VE) of PfSPZ Vaccine and PfSPZ-CVac against naturally occurring malaria in Indonesian soldiers deployed to eastern Indonesia.

NCT ID: NCT03494036 Recruiting - Clinical trials for Connective Tissue Diseases

Effect of Synbiotic on Immune Response, Gut Permeability and Microbiota in Patient With Connective Tissue Disease

Start date: October 1, 2017
Phase: N/A
Study type: Interventional

This is a double blind randomized placebo controlled trial to determine the effect of synbiotic to FOXP3 regulatory T cells, IL-17, gut permeability and gut microbiota in patients with connective tissue disease. Synbiotic can increase FOXP3 regulatory T cells, decrease IL-17 and improve gut permeability and gut microbiota in patients with connective tissue disease.

NCT ID: NCT03489824 Recruiting - Clinical trials for Water Immersion Method Colonoscopy in Unsedated Patients

Effectiveness of RL- vs LL-starting Position in Unsedated Water Immersion Colonoscopy

RLPvsLLP
Start date: February 20, 2018
Phase: N/A
Study type: Interventional

Abdominal discomfort is of the most important patient interest when in an unsedated colonoscopy examination. Water method for colonoscopy examination has been studied widely and evidence showed effectiveness in reducing discomfort and increase cecal intubation time and increasing cecal intubation rates in unsedated patients.

NCT ID: NCT03462108 Recruiting - Safety Issues Clinical Trials

Safety and Immunogenicity of Rotavirus (Bio Farma) Vaccine in Adults, Children & Neonates

Start date: April 9, 2018
Phase: Phase 1
Study type: Interventional

This study is to assess the safety of Rotavirus (Bio Farma) vaccine in adults, children and neonates.

NCT ID: NCT03455049 Recruiting - Increased Insulin Clinical Trials

The Effect of Andrographis Paniculata to GLP-1, Fasting Insulin, Insulin 2-h Post OGTT, and HOMA-IR

Start date: October 17, 2017
Phase: N/A
Study type: Interventional

Prevalence of type 2 diabetes have been increased, but medications had not been well, so that needed new alternatives. A new approach used in management of type 2 diabetes is incretin based therapy. Incretin hormone, glucagon-like peptide 1 (GLP-1) and glucose-dependent insulinotrophic peptide (GIP), had producted in intestine due to carbohydrate intralumen. After had secreted, GLP-1 had degradated by DPP-4 enzyme till number and effect had been decreased. Decreasing of GLP-1 effect as main defect in type 2 diabetes. Andrographis paniculata (A. paniculata) as traditional treatment had known since years ago to have hypoglycemia effect. Extract of A. paniculata consists of andrographolid and flavonoid. Based on study of Wooten et al that flavonoid has hydroxyl to stimulate insulin's production through modulated GLP-1 receptor (GLP-1 receptor ligand). So the investigators need to study about The Effect of A. paniculata Extract to GLP-1, Fasting Plasma Insulin, Insulin concentrations measured during a standardized 2-h OGTT, and HOMA-IR.

NCT ID: NCT03453281 Recruiting - Clinical trials for Diabetic Retinopathy

Early Anatomical, Physiological, and Clinical Changes in Diabetic Macular Edema After Intravitreal Aflibercept Injection

Start date: October 10, 2017
Phase: Phase 4
Study type: Interventional

This is a one month pre post intervention study. Subjects with diabetic macular edema were given intravitreal anti VEGF (Aflibercept) injection. Central retinal thickness, macular electrophysiology, and visual acuity were observed one week and one month after injection was given to the eye to describe early anatomical, physiological, and clinical changes. We hypothesized that changes to these outcomes can be found and documented.

NCT ID: NCT03434197 Recruiting - Clinical trials for Osteoarthritis Knee Pain

Safety and Efficacy of SFPP in Knee Osteoarthritis

Start date: February 5, 2018
Phase: Phase 3
Study type: Interventional

The objectives of this study are to demonstrate the non-inferiority of esflurbiprofen plaster (SFPP) 40 mg applied for 2 weeks to diclofenac gel, the comparator, in terms of efficacy in patients with knee osteoarthritis (OA) and to examine the safety of SFPP.

NCT ID: NCT03431649 Completed - Clinical trials for Pediatric Pulmonary Hypertension

Efficacy of Beraprost in Lowering Pulmonary Arterial Pressure in Children

Start date: April 1, 2017
Phase: Phase 4
Study type: Interventional

To analyze the efficacy of beraprost and sildenafil for treatment of pulmonary hypertension in children with left to right shunt. analyze the efficacy and side effects.

NCT ID: NCT03422575 Completed - Healthy Clinical Trials

Bioequivalence Study of 120 mg Etoricoxib Film-coated Tablets

Start date: December 2015
Phase: N/A
Study type: Interventional

The present study was a randomized, open-label, two-period, two-sequence, cross-over study, conducted to find out whether the etoricoxib 120 mg film-coated tablet produced by PT Dexa Medica (test drug) was bioequivalent to the reference drug (Arcoxia® Film-Coated Tablet 120 mg, PT. Schering-Plough Indonesia Tbk), under fasting condition with a fourteen days wash-out period, involving 26 healthy adult male and female subjects.