Clinical Trials Logo

Filter by:
NCT ID: NCT04851262 Recruiting - Sarcopenia Clinical Trials

Home-based Progressive Resistance Exercise to Enhance Physical Performance of Older Adults With Possible Sarcopenia

Start date: April 2021
Phase: N/A
Study type: Interventional

The overall aim of the proposed project is to improve muscle strength in older adults with possible sarcopenia by promoting home-based progressive resistance exercise. The target population for health talks is community-dwelling older adults. A Three monthly home-visits and weekly phone calls will be made. A waitlist randomised controlled trial will be conducted to evaluate effectiveness, and qualitative feedback will be collected from participants. A pilot study will be conducted first.

NCT ID: NCT04848896 Not yet recruiting - Arthroplasty Clinical Trials

Study to Evaluate the Safety and Effectiveness of the REAL INTELLIGENCE™ CORI™ in Total Knee Arthroplasty (TKA) Procedure

CORI RCT TKA
Start date: April 30, 2021
Phase: N/A
Study type: Interventional

Background: REAL INTELLIGENCE™ CORI™ (CORI Robotics) is a computer-assisted orthopaedic surgical navigation and burring system. CORI Robotics is designed to help surgeons in planning and executing certain types of knee surgery involving bone preparation. These types of surgery are called 'unicondylar knee arthroplasty' (UKA) and 'total knee arthroplasty' (TKA). Purpose: This study is being carried out to demonstrate the safety and effectiveness of the CORI Robotics in TKA procedure. The data collected will be used to demonstrate the safety and effectiveness of CORI and to register CORI in China mainland. The primary objective of this study is to evaluate the use of CORI in TKA procedure in achieving post-operative leg alignment as compared to procedures using conventional manual instruments. Research participants / locations: 140 research participants will be recruited from up to 8 sites in 3 countries globally (Australia, China Mainland, Hong Kong and New Zealand). There will be 70 patients having TKA using CORI and 70 patients having TKA using conventional procedure.

NCT ID: NCT04847804 Not yet recruiting - Covid19 Clinical Trials

Large-scale COVID-19 Population Screening

Start date: June 1, 2021
Phase:
Study type: Observational

Infectious diseases pose a threat to the life of individuals worldwide. The pandemic has highlighted the need to develop an innovative and cost- effective large population-based screening methodology. The investigators propose a two-fold improvement barcode-labeled testing strategy specifically for pooled samples. This platform combines isothermal amplification and real-time electrochemical detection; electroactive modified loop probes will be used in the amplification step for barcode readout. This method enables four samples pooled detection at the same time. This platform will be integrated into a disposable microfluidic chip that allows minimal human intervention during the process to realize a massively parallel screening platform for infectious disease pathogens. Objectives 1. To develop a sensing method for concurrent electrochemical-tag coded isothermal amplification and real-time electrochemical detection; 2. To design a molecular strategy to barcode four individual samples so that they can be pooled together and to simultaneously amplify and identify a positive individual, if any, from the pooled sample. 3. To fabricate a microfluidic device integrating the sample processor and barcoding module with the nucleic acid amplification and detection step for large-scale population screening of up to 100 individuals. 4. To validate the performance of the prototype using clinical specimens and benchmark it against the detection data from commercially available testing equipment.

NCT ID: NCT04845789 Not yet recruiting - Dementia Clinical Trials

Case Manager Approach in Dementia Care From a Caregiver Perspective

Start date: May 2, 2021
Phase:
Study type: Observational [Patient Registry]

This is a qualitative study to explore opinions of family caregivers of community-dwelling people with dementia on case manager approach in dementia care. Semi-structured interviews will be used for data collection. Purposive sampling was used to recruit caregivers from Jockey Club Centre for Positive Ageing. Grounded Theory would be used for data analysis.

NCT ID: NCT04843176 Recruiting - Liver Cancer Clinical Trials

Artificial Intelligence vs. LIRADS in Diagnosing HCC on CT

Start date: March 19, 2021
Phase: N/A
Study type: Interventional

Liver cancer is the sixth most commonly diagnosed cancer and the fourth leading cause of cancer death worldwide. It is the 3rd most common cause of cancer death in Hong Kong. The five-year survival rates of liver cancer differ greatly with disease staging, ranging from 91.5% in early-stage to 11% in late-stage. The early and accurate diagnosis of liver cancer is paramount in improving cancer survival. Liver cancer is diagnosed radiologically via cross sectional imaging, e.g. computed tomography (CT), without the routine use of liver biopsy. However, with current internationally-recommended radiological reporting methods, up to 49% of liver lesions may be inconclusive, resulting in repeated scans and a delay in diagnosis and treatment. An artificial intelligence (AI) algorithm that that can accurately diagnosed liver cancer has been developed. Based on an interim analysis, the algorithm achieved a high diagnostic accuracy. The AI algorithm is now ready for implementation. This study aims to prospective validate this AI algorithm in comparison with the current standard of radiological reporting in a randomized manner in the at-risk population undergoing triphasic contrast CT. This research project is totally independent and separated from the actual clinical reporting of the CT scan by the duty radiologist. The primary study outcome is the diagnostic accuracy of liver cancer, which will be unbiasedly based on a composite clinical reference standard.

NCT ID: NCT04841616 Not yet recruiting - Pancreas Neoplasm Clinical Trials

Multicentered Prospective Randomized Controlled Trial For Solid Pancreatic Lesions

Start date: July 1, 2021
Phase: N/A
Study type: Interventional

Endoscopic ultrasound (EUS) is an indispensable tool for tissue acquisition for pancreatic lesions. Fine needle aspiration (FNA) is once considered as the first line diagnostic method especially when rapid on-site evaluation (ROSE) by cytopathologist is available. However, FNA alone has several limitations including inadequate acquisition of cells, and unable to provide core tissue for further histological analysis. Furthermore, ROSE is not available in many endoscopic centres due to limited resources. Endosonographers around the world, are discovering methods to overcome the limitations, including the use of new on-site evaluation technique by endoscopists, new fine-needle biopsy (FNB) needles, contrast-enhanced harmonic EUS-guided FNB. In this study, the investigators propose to compare the diagnostic performance between contrast-enhanced EUS-guided FNB versus conventional EUS-guided FNB technique with an aim to define the best EUS-guided tissue acquisition technique in the absence of ROSE. Results obtained from this research is expected to have significant impact in providing new insights on the best EUS-guided tissue acquisition method. It may replace FNA with ROSE as the gold standard for EUS-guided tissue acquisition in an affordable manner. It will also save the patients from unnecessary procedures and fasten the treatment pathways.

NCT ID: NCT04840303 Recruiting - Mental Stress Clinical Trials

The Effectiveness and Cost-effectiveness of Mental Wellness Youth Hub

Start date: November 1, 2019
Phase: N/A
Study type: Interventional

The proposed study is to be carried out with 6000-7000 youths aged 12 - 24 in Hong Kong. The purpose of the study is to investigate the effectiveness and cost-effectiveness of a Hub project for young people: [email protected] This study is conducted by [email protected] in collaboration with partnering NGOs including the Boys' & Girls' Clubs Association of Hong Kong (BGCA), Caritas Hong Kong, Hong Kong Federation of Youth's Group (HKFYG), Hong Kong Playground Association (HKPA), Hong Kong Children and Youth Services (HKCYS) and St James' Settlement (SJS). It is a 1-year quasi experimental controlled study which aims to examine if these hubs can enhance young people's cognitive abilities, personal strengths and overall mental well-being. 1300 participants would be recruited, including 600 Hub users, 600 non-hub users (but receiving services from participating NGOs), and 100 community youth not receiving any youth services. Participants will be assessed at baseline and follow-ups (e.g., 3 months, 6 months, and 12 months); completing questionnaires and answering questions during a 3- hour interview. Hub users with mild to moderate mental distress will receive different psychological treatments according to their needs. For youths who are at risk for mental disorders, diagnostic and medical assessment services will be delivered by psychiatrists or clinical psychologists. Findings will allow us to better understand the effectiveness of this kind of community-based hubs for young people, improve mental wellness training of youth social workers; and in a long run, develop a community-based support model that is sustainable, scalable and replicable.

NCT ID: NCT04830072 Not yet recruiting - Smoking Cessation Clinical Trials

AR Enhanced Pictorial Warnings on Smoking Cessation

Start date: April 9, 2021
Phase: N/A
Study type: Interventional

This pilot randomized controlled trail aims to test the effects of AR enhanced pictorial effects in harms of smoking and benefit of smoking cessation.

NCT ID: NCT04826835 Not yet recruiting - Lung Cancer Clinical Trials

A Prehabilitation Program to Boost Postoperative Functional Capacity in Surgical Lung Cancer Patients

Start date: May 1, 2021
Phase: N/A
Study type: Interventional

This research study is evaluating a prehabiliation intervention designed to improve postoperative functional capacity (measured by 6-minure walking distance) in individuals undergoing lung resection for cancer.

NCT ID: NCT04826796 Recruiting - Breastfeeding Clinical Trials

Feasibility and Effectiveness of WhatsApp Online Group on Breastfeeding by Peer Counsellors.

Start date: March 5, 2021
Phase: N/A
Study type: Interventional

Due the uncertainty of the pandemic wave and government restrictions that may affect health care services and behaviour, alternative mhealth strategies should be explored to identify breastfeeding support or problems early to prevent subsequent cessation that may affect mother and child health. It is also important to understand the feasibility of a WhatsApp online group on breastfeeding by peer counsellors during postnatal period and the acceptability of such intervention. Therefore this study will provide preliminary information necessary for implementation of a full RCT of mhealth intervention in the future. The aim of this study is to examine the feasibility and effectiveness of a WhatsApp online peer support group program in improving breastfeeding practices. There have been no published studies that have examined the feasibility and acceptability of a Whatsapp online group on breastfeeding for postnatal women in Hong Kong. Given the significant pandemic problem that may affect health services and health behavior of pregnant women, the proposed study will contribute substantial new information about the feasibility and potential implications for future care pathways for postnatal women. Such information will be invaluable to public health professional working to breastfeeding promotion and to health policy makers in setting institutional policies.