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NCT ID: NCT03305185 Not yet recruiting - Clinical trials for Adolescent Idiopathic Scoliosis

Efficacy of Scoliosis Specific Exercise in Patients With Adolescent Idiopathic Scoliosis During Bracing

Start date: October 9, 2017
Phase: N/A
Study type: Interventional

The purpose of this study is to examine the effectiveness of Schroth scoliosis-specific exercises (SSE) on patients with adolescent idiopathic scoliosis (AIS) during bracing. The goal is to determine if Schroth SSE combined with bracing can is superior in controlling curve progression when compared with bracing alone. Curve progression is defined as worsening of coronal Cobb angle of 6 degrees or more.

NCT ID: NCT03304405 Completed - Clinical trials for Adult Spinal Deformity

Influence of Sagittal Imbalance of the Spine on Gait Pattern in Adult Spinal Deformity

Start date: June 1, 2016
Phase: N/A
Study type: Observational

This study intends to investigate the changes in gait pattern in adult spinal deformity (ASD) patients with sagittal imbalance. It will investigate the gait kinematics in patients who have a mismatch of their spinopelvic parameters, and a positive sagittal balance. The investigators hypothesise that patients with abnormal spinopelvic parameters may demonstrate a pathological gait pattern.

NCT ID: NCT03304236 Recruiting - Cervical Myelopathy Clinical Trials

Motion Analysis of the Myelopathy Hand: New Insight Into the Classical Sign

Start date: July 1, 2017
Phase: N/A
Study type: Observational

This study aims to quantify the clumsiness and decreased dexterity seen in the grip and release test using a simple glove with sensors that can quantify the abnormal motion of this classical sign. This new tool will give a mechanistic insight into the myelopathy. The findings of this study will also form the basis of a prospective longitudinal study with clinical and radiological evaluation to compare the prognosticating value of this new information in clinical practice.

NCT ID: NCT03302468 Recruiting - Endometriosis Clinical Trials

Development and Validation of EHP-30 (Hong Kong Chinese Version) for Patients With Endometriosis and Adenomyosis

Start date: August 6, 2015
Phase: N/A
Study type: Observational

Endometriosis and adenomyosis can impact on the quality of life including the physical, psychological and social aspects. It is important to include quality of life measurements in evaluating the disease severity and response to any given treatment. The 30-item Endometriosis Health Profile (EHP-30), derived from in-depth interviews of patients with endometriosis, is currently the most reliable questionnaire for health-related quality of life measurement in women with endometriosis. It includes specific questions addressing the problems faced by patients with endometriosis. Unfortunately, this widely accepted tool does not have a traditional Chinese version for the measurement of health-related quality of life of endometriosis in Hong Kong. Furthermore, adenomyosis and endometriosis share similar histological and clinical symptomatology, but application of EHP-30 to adenomyosis has never been studied. The aims of the present study are to translate the EHP-30 English version into traditional Chinese version and to evaluate its psychometric properties in endometriosis and adenomyosis. The hypothesis of this study is that EHP-30 (Hong Kong) traditional Chinese questionnaire has high internal consistency, construct validity, reproducibility as the original English version and can be applicable to Hong Kong Chinese women with endometriosis and adenomyosis.

NCT ID: NCT03301402 Recruiting - Clinical trials for Cognitive Impairment

Air Purifier to Improve Endothelial Function and Carotid Intima Thickness

Start date: September 22, 2017
Phase: N/A
Study type: Interventional

Background: There is epidemiological evidence or link ambient air pollution exposure to the incidence of dementia. Aims or hypotheses: It is hypothesized that reduction in indoor pollutants from air purification improves endothelial function and carotid intima thickness in older diabetic people with cognitive impairment. Subjects and method: People with clinically diagnosis mild cognitive impairment or early dementia will be recruited. After obtaining written consent, the subjects will be assessed cognitive function and arterial health. After baseline measurements, the subjects are randomly assigned to have either filter or no filter installed in the air purifier. The air purifier will be placed in living room of the household of the subject for one year. At one year, the measurements will be repeated. Statistical analysis: Intention to treat analysis will be adopted.

NCT ID: NCT03301194 Recruiting - Hypertension Clinical Trials

Cost-effectiveness of RAMP-HT for Patients With Uncontrolled Hypertension in Hong Kong

Start date: April 1, 2016
Phase: N/A
Study type: Observational

Hypertension (HT) is an important risk factor for stroke, coronary heart disease (CHD), heart failure and renal diseases, and the leading risk factor of global disease burden. A multitude of interventions have proven efficacy in lowering blood pressure and reducing long term HT complications, including pharmacologic treatment, DASH diet (Dietary Approaches to Stop Hypertension), exercise, weight reduction, smoking cessation, alcohol moderation and self-monitoring of blood pressure. Objectives: To evaluate long-term effectiveness and cost-effectiveness of Risk-Assessment-and-Management-Programme-for-Hypertension (RAMP-HT), a multi-disciplinary structured service to enhance quality of hypertension care in primary care compared to usual care Hypotheses: 1. RAMP-HT is effective in reducing HT complications, based on previous results showing RAMP-HT was effective in improving patients' blood pressure 2. RAMP-HT is cost-effective Design and Subjects: Retrospective study of 5-year longitudinal data on matched cohorts of public primary care patients with uncontrolled HT under RAMP-HT and usual care will be conducted to evaluate long-term effectiveness and direct medical costs. Results from the long-term effectiveness and costing analyses will be applied to Markov modeling to determine the life time cost-effectiveness of RAMP-HT. Main outcome measures: 1. 5-year incidence of cardiovascular complications 2. Direct medical costs of RAMP-HT and usual care HT patients 3. Incremental cost-effectiveness ratio (ICER) of cost per quality-adjusted life year (QALY) gained by RAMP-HT compared to usual care Data analysis: Cox regression will be performed to estimate the effect of RAMP-HT on the development of HT complication adjusted for baseline covariates. Descriptive statistics will be used to calculate costs of RAMP-HT and annual direct medical costs for HT patients. Markov modeling will be used to simulate 2 patient cohorts (RAMP-HT versus usual care) to estimate the respective lifetime direct medical costs and QALY gained/person. Cost/QALY of RAMP-HT will be compared to that of usual care to determine the ICER. Expected results: The results can provide evidence on the effectiveness and cost-effectiveness of RAMP-HT for primary care patients with uncontrolled HT, which can inform health policy and service planning.

NCT ID: NCT03300804 Completed - Clinical trials for Irritable Bowel Syndrome

Dose Escalation Trial of Traditional Chinese Medicine for Irritable Bowel Syndrome (TCM- IBS)

TCM-IBS
Start date: May 2008
Phase: Phase 2
Study type: Interventional

The purpose of this study is to determine whether a 20- herb formulation, as a well characterised extract, is efficacious in treating irritable bowel syndrome (IBS) and also to identify efficacious and safe dosage of the formulation in treating IBS.

NCT ID: NCT03299400 Completed - Clinical trials for Intraocular Pressure

Continuous Intraocular Pressure Patterns in Spine Surgery

Start date: May 9, 2016
Phase: N/A
Study type: Interventional

Post-operative visual loss is a rare but serious complication after surgery. It is most significantly correlated with prone spinal surgery with a prolonged duration. The cause and risk factors are not elucidated, but the majority of the cases are due posterior ischaemic optic neuropathy (PION). This entity is directly related to the ocular perfusion pressure (OPP), which is estimated as the difference between mean arterial blood pressure (MAP) and intraocular pressure (IOP). Autoregulation is believed to maintain a constant perfusion to the optic nerve despite fluctuations in the perfusion pressure. IOP is known to increase in the prone position thus putting susceptible patients at risk for inadequate ocular nerve perfusion. Most of the evidence comes from animal and healthy volunteer studies and cannot give an accurate insight into the subtle changes of intra-operative IOP. All the published studies employed the use of a tonometer, which may have rooms for measurement errors due to inadvertent pressure on the globe while retracting the eyelids, particularly when there is significant periorbital/conjunctival swelling in the prone position. The majority of the studies recruited healthy volunteers in a simulated surgical setting so other fluctuating parameters, which can affect intraoperative IOP, cannot be measured. In the few reports where patients undergoing surgery in the prone position were studies, IOP measurements were taken at non-continuous monitoring at time intervals, thus the effects of changes in blood volume, MAP, central venous pressure (CVP) and PaCO 2 could not be studied. Lastly, all the literature consists of case series only with no control group so the effect of position cannot be evaluated independently of the other factors. The investigators therefore propose to conduct a prospective study with continuous intraoperative IOP monitoring to give us further insight into the physiological changes of IOP in patients undergoing spine surgery, and identify the risk factors related to fluctuations of IOP during prone spinal surgery.

NCT ID: NCT03299010 Recruiting - Clinical trials for Cardiovascular Diseases

10-year Risk Prediction Models of Complications and Mortality of DM in Hong Kong

Start date: July 1, 2017
Phase: N/A
Study type: Observational

Diabetes Mellitus (DM) is a well-recognized public health issue, affecting 415 million people and costing HK$5.2 trillion in global health expenditures worldwide. It is estimated 568,000 people are living with DM in Hong Kong, and the projected number will increase to 781,000 in 2040. In Hong Kong, the health care costs for diabetic patients are estimated to be HK$2 billion accounting for 4.5% of the gross domestic product (GDP) per capita, and a major health service burden accounting for 200,000 (17% of total) hospital admissions with 1.2 million hospitalization days per year. DM can lead to many complications resulting in morbidity and mortality. According to the International Diabetes Federation (IDF), in 2015, diabetes led to 5.0 million (14.5% of all deaths) deaths worldwide which translated to one death every six seconds and approximately 70% of DM related deaths were attributed to cardiovascular diseases (CVD). The development of diabetes-related complications significantly increases medical costs. A previous local study also found that the direct medical cost for diabetic patients with CVD were 1.1 times more than patients without CVD in Hong Kong. Objectives: To develop 10-year risk prediction models for total CVD and all-cause mortality among Chinese patients with DM in primary care. Risk prediction models for individual DM complications including coronary heart disease, heart failure, stroke and end stage renal disease (ESRD) will also be developed. Hypotheses: 1. Patient socio-demographic, clinical parameters, disease characteristics and treatment modalities are predictive of 10-year risk of total CVD, all-cause mortality and individual DM complication. 2. Risk prediction models developed from this study should have over 70% of discriminating power. Design and Subjects: 10-year retrospective cohort study. All Chinese patients who were clinically diagnosed to have DM and were receiving care in the Hospital Authority primary care clinics on or before 1 July 2006 will be followed up until 31 December 2016. Main outcomes measures: For total CVD, all-cause mortality and each major DM complication 1. 10-year incidence; 2. Predictive factors Data analysis: The analyses will be carried out separately for men and women. Two thirds of subjects will be randomly selected as the training sample for model development. Cox regressions will be used to develop 10-year risk prediction models of total CVD, all-cause mortality and each major DM complication. The validity of models will be tested on the remaining one third of subjects by receiver operating characteristic curve. Expected results: Risk prediction models for diabetic complications specific to Chinese patients in primary care will enable accurate risk stratification, prioritization of resources and more cost-effective interventions for DM patients in primary care.

NCT ID: NCT03298971 Recruiting - Clinical trials for Childhood Osteosarcoma

The Impact of Cancer on the Physical and Psychosocial Well-being Among Childhood Osteosarcoma Survivors

Start date: September 8, 2017
Phase: N/A
Study type: Observational

The aim of the study is to examine the impact of cancer and treatment-related effects on the physical and psychosocial well-being and quality of life among Hong Kong Chinese survivors of childhood osteosarcoma.