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NCT ID: NCT03533010 Not yet recruiting - Scoliosis Clinical Trials

Prevent Curve Progression and Bracing in Early Adolescent Idiopathic Scoliosis With Calcium + Vitamin D Supplementation

Start date: July 1, 2018
Phase: N/A
Study type: Interventional

There is an association between adolescent idiopathic scoliosis (AIS) and low bone mass which has been reported to be a significant prognostic factor for curve progression. Given that dietary calcium (Ca) intake and serum Vit-D levels were also low in AIS, we therefore propose a randomized double-blinded placebo-controlled trial to evaluate if daily [500mg Ca + 800 IU Vit-D] can improve bone health and prevent curve progression in AIS. Immature AIS girls with Cobb angle 10-20 degrees will be randomized either to the Treatment or Placebo group with 3-year of treatment. The main outcome measures for evaluation for those who have completed the 3-year treatment and have reached skeletal maturity at the end of 3-year treatment include: (1) percentage of patients with increase in Cobb angleā‰„6 degrees and (2) percentage of patients who require bracing. Bone measurements using advanced image acquisition technology(HR-pQCT) to assess bone health will also be evaluated.

NCT ID: NCT03530917 Recruiting - Clinical trials for Healthy Participants

Assess the Safety and Tolerability of Single and Multiple Ascending Doses of Oral RO7020531 in Chinese Healthy Participants

Start date: May 15, 2018
Phase: Phase 1
Study type: Interventional

To evaluate safety and tolerability of single and multiple ascending doses of oral RO7020531 in Chinese healthy participants

NCT ID: NCT03522701 Recruiting - Insomnia Clinical Trials

Effects of Self-help Versus Group Cognitive Behavioural Therapy for Insomnia in Youth

Start date: May 15, 2018
Phase: N/A
Study type: Interventional

Insomnia is the most prevalent sleep problem in both the general and clinical populations. Insomnia symptoms, presented as the problems initiating sleep or maintaining sleep, have been reported in association with adverse outcomes in adolescents, including an increased risk of developing depression, anxiety, interpersonal problems, somatic health problems, self-harm and suicidal ideation. Moreover, adolescent insomnia has been found to predict the development of mental health problems in young adulthood. Currently there is no medication specifically approved for use as hypnotics in children under age 18 by the US Food and Drug Administration (FDA). Although cognitive behavioural therapy for insomnia (CBT-I) has been regarded as the first-line treatment for insomnia in adults, there exists limited evidence for the efficacy of CBT-I among adolescents and young adults. Given the high prevalence and profound consequences of insomnia among youth, further research on the short-term and long-term effects of CBT-I for adolescents is warranted. To address the limitations of the existing literature, this randomised controlled trial aims to examine whether face-to-face (group-based CBT-I) versus self-help insomnia treatment benefit adolescents with insomnia, for improving sleep and other clinical and daytime symptoms as well as overall functional improvement in both the short and long term.

NCT ID: NCT03518580 Completed - Aging Clinical Trials

Active Life Engagement in Relation to Health-related Outcomes Among Community-dwelling Chinese Older Adults

Start date: July 2, 2017
Phase:
Study type: Observational

This study aims to examine within-person variations of different contexts (time, physical, psychosocial and affective) of active life engagement, and how these variations predict a set of physiological indicators and health-related outcomes among community-dwelling older people. Specifically, this study has the following objectives. Objective 1: To investigate within-person variations in different contexts (i.e., time, physical, psychosocial, and affective) of active life engagement and interactions of these contexts. Objective 2: To examine how within-person variations in different contexts (i.e., time, physical, psychosocial, and affective) of active life engagement and interactions of these contexts may associate with a set of cardiovascular indicators measured on daily basis. Objective 3: To examine how within-person variations in different contexts (i.e., time, physical, psychosocial, and affective) of active life engagement and interactions of these contexts may associate with a set of health-related outcomes (e.g., physical functioning, depression, health-related quality of life).

NCT ID: NCT03505190 Not yet recruiting - Clinical trials for Healthy Participants

A Study to Evaluate the Safety, Tolerability and Pharmacokinetics of RO7062931 in Healthy Chinese Volunteers.

Start date: May 5, 2018
Phase: Phase 1
Study type: Interventional

This randomized study will evaluate the safety, tolerability and pharmacokinetics of single ascending subcutaneously administered doses of RO7062931 in healthy volunteers.

NCT ID: NCT03504254 Recruiting - Neurologic Disorder Clinical Trials

A fMRI Study of Compressive Spinal Cord

CSM Plasticity
Start date: January 11, 2012
Phase:
Study type: Observational

Cervical myelopathy (CM), a chronically compressive spinal cord lesion, is the most common cause of non-traumatic paraparesis/quadriparesis among the elderly. Hong Kong is facing a heavy social economic burden from CM with the rapidly aging population. Surgical decompression is considered as the mainstay of the treatment for CM patients to relieve their symptoms and signs. Yet the surgical outcome is not always satisfactory. There is a pressing need for understanding the exact mechanism of surgical decompression on the recovery of myelopathic cord in order to improve the prognosis of CM patients in near future.This project will evaluate neuronal activities and axon regeneration by longitudinally monitoring at time zero, 3 and 6 month after the surgery in CM patients using UTE, BOLD-fMRI and DTI, and to investigate the relationship of preoperative neuronal activities of myelopathic cord with axon regeneration.

NCT ID: NCT03501862 Recruiting - Clinical trials for Recent-onset Psychosis

Mindfulness Intervention for People With Psychosis

Start date: January 15, 2017
Phase: N/A
Study type: Interventional

People with schizophrenia demonstrated a tendency to use maladaptive cognitive emotion regulation strategies as compared with healthy control groups. The present study is the first randomized controlled trial of group mindfulness-based intervention for psychosis. Half group will join the mindfulness-based cognitive intervention while another half will participate in psychoeducation to examine whether mindfulness will have a positive impact on emotion regulation and distress.

NCT ID: NCT03494842 Enrolling by invitation - Clinical trials for Termination of Pregnancy

TENS for Suction Evacuation for Termination of 1st Trimester Pregnancies

Start date: April 26, 2018
Phase: N/A
Study type: Interventional

To study the effectiveness of the pain relief method of transcutaneous electrical nerve stimulation (TENS) for women who will undergo suction evacuation under conscious sedation for first trimester termination of pregnancy.

NCT ID: NCT03489317 Recruiting - Metabolic Syndrome Clinical Trials

Gut Microbiomes in Patients With Metabolic Syndrome

Start date: April 2018
Phase:
Study type: Observational

Metabolic syndrome (MS) is defined by a manifestation of cardiometabolic risk factors including high blood pressure, glucose and triglycerides, low high-density lipoprotein (HDL) cholesterol, and abdominal obesity. It is closely associated with other diseases such as fatty liver and gouty arthritis. In recent years there is evidence that gut microorganisms are intimately linked to health and wellbeing. Here, the investigators hypothesize that gut microorganisms are involved in the regulation and/or onset of MS and its symptoms.

NCT ID: NCT03484689 Recruiting - Clinical trials for Diabetes Mellitus, Type 2

MBCT for DM Distress: a Pilot Qusai-experimental Study

Start date: July 14, 2018
Phase: N/A
Study type: Interventional

Background: Diabetes-related distress (DRD) is very common among people with type II diabetes mellitus (DM). DRD led to poorer DM control and may led to adverse prognosis. Yet, there is no widely accepted or recommended DRD treatment. Mindfulness was shown to relieve psychological distress in various physical and mental conditions. Aim: as a pilot project, we aim to determine if mindfulness-based cognitive therapy (MBCT), which is one of the widely used mindfulness program, is feasible and acceptable and may improve DRD in our Chinese population. Method: 20 Chinese participants with suboptimally controlled DM and high DRD will be recruited to a 8- week MBCT group. Pre-group and post-group (immediate and 2-month post-group) data including DRD score, quality-of life measures will be compared.