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NCT ID: NCT05426759 Completed - Atrial Fibrillation Clinical Trials

Atrial Deganglionation as a Therapy for Cardiac Surgery Patients With Atrial Fibrillation

Neural-AF-2
Start date: June 1, 2022
Phase: N/A
Study type: Interventional

A prospective single-arm study of ganglionated plexi ablation in cardiothoracic surgery patients with a history of atrial fibrillation.

NCT ID: NCT05391022 Completed - Solid Tumor Clinical Trials

Study Evaluating Food Effect and QTc in Patients With Advanced Malignancies

Start date: July 20, 2021
Phase: Phase 1
Study type: Interventional

Phase 1 2-part study to evaluate the effect of food on pharmacokinetics of pelabresib (CPI-0610) and the effect of pelabresib on QTc in patients with advanced malignancies

NCT ID: NCT05372939 Completed - Ulcerative Colitis Clinical Trials

Study of the Efficacy and Safety of AMT-101 in Combination With Adalimumab in Subjects With Ulcerative Colitis (MARKET)

Start date: February 5, 2021
Phase: Phase 2
Study type: Interventional

Randomized, Placebo-controlled, Double-blind, Parallel-group, Multicenter, Phase 2a Study of the Efficacy and Safety of Oral AMT-101 in Combination With Adalimumab in Subjects with Moderate to Severe Ulcerative Colitis.

NCT ID: NCT05352893 Completed - Clinical trials for Generalized Pustular Psoriasis

Study to Evaluate the Efficacy and Safety of Imsidolimab (ANB019) in the Treatment of Subjects With GPP

GEMINI1
Start date: April 14, 2022
Phase: Phase 3
Study type: Interventional

This is a Phase 3, multicenter, randomized, double-blind, placebo-controlled study to evaluate the efficacy and safety of imsidolimab compared with placebo in adult subjects with generalized pustular psoriasis (GPP).

NCT ID: NCT05322122 Completed - Obesity Clinical Trials

Creation of Side-to-Side Compression Anastomosis Using the Magnetic Anastomosis System

Start date: November 18, 2021
Phase: N/A
Study type: Interventional

This is an operationally seamless, open-label, multicenter study enrolling up to 50 subjects with obesity and with or without type 2 diabetes at up to 5 study centers across Canada and Europe who will undergo sleeve gastrectomy (revision or de novo) with side-to-side anastomosis duodeno-ileostomy using the MAGNET System and will be followed for 12 months.

NCT ID: NCT05315544 Completed - Clinical trials for Coronary Artery Disease

Cardiovascular Systems Inc. (CSI) pVAD First in Human Study

Start date: March 14, 2022
Phase: N/A
Study type: Interventional

This study will collect initial clinical data on the CSI pVAD system to inform device design and finalization.

NCT ID: NCT05271734 Completed - Clinical trials for OAG - Open-Angle Glaucoma

Evaluation of the Compatibility of Different Eye Lid Retractors to the Direct Selective Laser Trabeculoplasty (DSLT) Procedure

Start date: June 6, 2021
Phase: N/A
Study type: Interventional

Direct Selective Laser Trabeculoplasty (DSLT) is an emerging therapeutic technology to treat glaucoma. DSLT was previously tested in 2 clinical trials and demonstrated promising safety and efficacy results in reducing the patient's intra ocular pressure. Experience gained in the previous clinical studies indicates that a full exposure of the limbal area may be a challenge in patients with narrow palpebral fissures, narrow or floppy eyelids, and patients with deep-set eyes.

NCT ID: NCT05198310 Completed - Clinical trials for Arthritis, Rheumatoid

Study to Assess the Safety, Pharmacokinetics, and Efficacy of KPL-404 in Participants With Rheumatoid Arthritis With Inadequate Response or Intolerance to at Least One Biologic Disease-modifying Anti-rheumatic Drug or a Janus Kinase Inhibitor

Start date: December 14, 2021
Phase: Phase 2
Study type: Interventional

Phase 2 study of the safety, tolerability, pharmacokinetics (PK), pharmacodynamics (PD) and efficacy of KPL-404 in subjects with moderate to severe Rheumatoid Arthritis.

NCT ID: NCT05133323 Completed - Migraine Clinical Trials

A Study With Lu AG09222 in Adults With Migraine Who Have Not Been Helped by Prior Preventive Treatments

Start date: November 11, 2021
Phase: Phase 2
Study type: Interventional

Researchers are trying to learn whether a drug called Lu AG09222 can help prevent migraine headaches for people who have not been helped by other treatments that are used to prevent migraines. People who join this trial have tried 2 to 4 other medications to prevent their migraines, but these medications have not helped them. When the trial is over, researchers will use this information to find out if the number of migraine days decreased more for the participants who got either dose of Lu AG09222 than for the participants who got the placebo.

NCT ID: NCT05133089 Completed - Heart Failure Clinical Trials

ALLEVIATE-HFrEF Study

Start date: August 10, 2021
Phase: Phase 1
Study type: Interventional

Patients with heart failure and reduced left ventricular ejection fraction (HFrEF, EF ≤ 40%) with mild to moderate functional limitation will be evaluated for treatment via creation of a no-implant interatrial shunt using clinical, echocardiographic, and invasive hemodynamic data.