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NCT ID: NCT05695716 Not yet recruiting - Clinical trials for Coronary Artery Disease

CSI Percutaneous Ventricular Assist Device (pVAD) Second in Human Study

Start date: February 2023
Phase: N/A
Study type: Interventional

The purpose of this study is to collect data on safety and device performance on the CSI pVAD System used to support hemodynamic stability during HR-PCIs to inform device design and finalization.

NCT ID: NCT05692518 Recruiting - Obesity Clinical Trials

DI Bio-fragmentable MAGNET Feasibility Study

Start date: December 19, 2022
Phase: N/A
Study type: Interventional

The purpose of this clinical research study is to evaluate the feasibility of the GT Metabolic Solutions DI Bio-fragmentable Magnetic Anastomosis System (MAGNET System, DI Bio-fragmentable) for creation of a side-by-side anastomosis duodeno-ileostomy in obese adults.

NCT ID: NCT05685615 Not yet recruiting - Clinical trials for Ventilator Associated Pneumonia

PK of BV100 in Patients VABP Suspected or Confirmed to be Due to CRAB

Start date: February 1, 2023
Phase: Phase 2
Study type: Interventional

A multicenter Phase 2 study to evaluate the pharmacokinetics, efficacy, and safety of intravenous BV100 combined with Polymyxin B in adult patients with VABP suspected or confirmed to be due to CRAB

NCT ID: NCT05685303 Enrolling by invitation - Heart Failure Clinical Trials

Alleviant ALLAY-HF Study

Start date: January 10, 2023
Phase: N/A
Study type: Interventional

Prospective, multicenter, randomized, sham-controlled, double blinded, adaptive study designed to evaluate the safety and efficacy of a percutaneously created interatrial shunt using the Alleviant ALV1 System in patients with HFpEF/HFmrEF.

NCT ID: NCT05682066 Recruiting - Clinical trials for Mitral Valve Regurgitation (Degenerative or Functional)

TVMR With the Innovalve System Trial - Pilot in Georgia

TWIST-PILOT-GE
Start date: December 1, 2021
Phase: N/A
Study type: Interventional

Study to evaluate the safety and performance of the Innovalve mitral valve replacement system

NCT ID: NCT05639192 Recruiting - COVID-19 Clinical Trials

Asunercept for the Treatment of Patients With Moderate to Severe COVID-19 Disease

ASUCOV
Start date: November 3, 2022
Phase: Phase 3
Study type: Interventional

This clincial trial is a prospective, multicenter, randomized, double-blind, placebo-controlled Phase III trial in hospitalized patients with moderate to severe COVID-19 corresponding to score 5 or 6 on the WHO 10-point clinical progression scale (Grade 0-10). The investigational drug (APG101; International Nonproprietary Name: asunercept) will be given at a dose of 100 mg intravenously (i.v.) once weekly for a period of 4 weeks (1 dose each on d1, d8, d15, and d22) in addition to the treatment recommended by international, national, or local treatment guidelines (SoC) and will be compared with the control arm (i.e., SoC + placebo).

NCT ID: NCT05600088 Active, not recruiting - Clinical trials for Coronary Artery Disease

Intracoronary Cryotherapy Effect on Stabilization of Vulnerable Plaque in Patients With NSTEMI or Unstable Angina

POLARSTAR
Start date: October 18, 2022
Phase: N/A
Study type: Interventional

The POLARSTAR study is an early feasibility study to evaluate the performance and safety of the CryoTherapy System (CTS) for the treatment of coronary plaque lesions that are not obstructing blood flow but are at high-risk of rupture which would cause a major heart attack. The CTS is used to apply local freezing of the lesion using a balloon catheter, controlled by a console that regulates in- and outflow of a cooling agent into the catheter. The treatment is expected to stabilize the lesion, diminishing the risk of rupture. The study will enrol subjects with acute coronary disease who have suitable coronary lesions. Subjects will be followed for 1 year after the CTS treatment. Baseline identification of lesions will be done using Coronary CT-angiography (CCTA), which will be repeated at 3 and 9 months after procedure.

NCT ID: NCT05600049 Not yet recruiting - Lentigo Solar Clinical Trials

Tolerance and Performance of Cyto-selective Difluoroethane-based Cryotherapy in the Treatment of Brown Spots

Start date: November 2022
Phase: N/A
Study type: Interventional

CS5_1 study aim to evaluate the tolerance and to adjust the mode of administration of 4 different conditions of cryotherapy treatments applied on the brown spots of the face and hand with 3 prototypes. Each treatment corresponds to a combination of a specific sequence of a cryogenic spray and of a frequency of application. The study will evaluate 3 prototypes : - Prototype 1 : from (815-v1 001) to (815-v1 100) - Prototype 2 : from (815-v1 101) to (815-v1 150) - Prototype 3 : from (815-v1 151) to (815-v1 200)

NCT ID: NCT05592392 Enrolling by invitation - Clinical trials for Heart Failure With Reduced Ejection Fraction

RECOVER-HF Pilot Study of SDS in Heart Failure

Start date: August 23, 2022
Phase: N/A
Study type: Interventional

The RECOVER HF pilot is a feasibility study for evaluating a randomized, doubled-blinded study design to determine the benefits and risks of chronically delivering Synchronized Diaphragmatic Stimulation (SDS) in Heart Failure patients on GDMT with NYHA II/III, EF<=40% and QRSd,=130ms.

NCT ID: NCT05577351 Not yet recruiting - Clinical trials for Acute Ischemic Stroke

Feasibility Study of RapidPulseTM Aspiration System as Frontline Approach for Patients With Acute Ischemic Stroke

PULSE-F
Start date: November 2022
Phase: N/A
Study type: Interventional

A feasibility study to evaluate the initial safety and performance of the RapidPulseTM Aspiration System in the treatment of patients with Acute Ischemic Stroke (AIS) due to Large Vessel Occlusion (LVO) in the intracranial ICA, M1, M2, basilar or vertebral arteries.