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NCT ID: NCT05426759 Recruiting - Atrial Fibrillation Clinical Trials

Atrial Deganglionation as a Therapy for Cardiac Surgery Patients With Atrial Fibrillation

Neural-AF-2
Start date: June 1, 2022
Phase: N/A
Study type: Interventional

A prospective single-arm study of ganglionated plexi ablation in cardiothoracic surgery patients with a history of atrial fibrillation.

NCT ID: NCT05403372 Recruiting - Heart Failure Clinical Trials

Evaluation of an Implant Free Interatrial Shunt to Improve Heart Failure

EASE HF
Start date: May 7, 2022
Phase: N/A
Study type: Interventional

This is a prospective, single arm feasibility study to establish safety and performance of the PAS-C System in subjects with heart failure and elevated left atrial pressure.

NCT ID: NCT05372939 Active, not recruiting - Ulcerative Colitis Clinical Trials

Study of the Efficacy and Safety of AMT-101 in Combination With Adalimumab in Subjects With Ulcerative Colitis (MARKET)

Start date: February 5, 2021
Phase: Phase 2
Study type: Interventional

Randomized, Placebo-controlled, Double-blind, Parallel-group, Multicenter, Phase 2a Study of the Efficacy and Safety of Oral AMT-101 in Combination With Adalimumab in Subjects with Moderate to Severe Ulcerative Colitis.

NCT ID: NCT05366855 Recruiting - Clinical trials for Generalized Pustular Psoriasis

Long-Term Safety and Efficacy of Imsidolimab (ANB019) in Subjects With Generalized Pustular Psoriasis

GEMINI2
Start date: April 21, 2022
Phase: Phase 3
Study type: Interventional

This is a Phase 3, long term extension study to evaluate the safety and efficacy of imsidolimab compared with placebo in adult subjects with generalized pustular psoriasis (GPP).

NCT ID: NCT05352893 Recruiting - Clinical trials for Generalized Pustular Psoriasis

Study to Evaluate the Efficacy and Safety of Imsidolimab (ANB019) in the Treatment of Subjects With GPP

GEMINI1
Start date: April 14, 2022
Phase: Phase 3
Study type: Interventional

This is a Phase 3, multicenter, randomized, double-blind, placebo-controlled study to evaluate the efficacy and safety of imsidolimab compared with placebo in adult subjects with generalized pustular psoriasis (GPP).

NCT ID: NCT05338086 Recruiting - Clinical trials for Postmenopausal Women With Osteoporosis

A Study to Compare Efficacy, Pharmacokinetics, Pharmacodynamics, Safety and Immunogenicity of MB09 [Proposed Denosumab Biosimilar] to Prolia® [EU-sourced] in Postmenopausal Osteoporosis (SIMBA Study)

Start date: March 31, 2022
Phase: Phase 3
Study type: Interventional

This is a randomized, double-blind, parallel, multicenter, multinational study to compare the efficacy, pharmacokinetics, pharmacodynamics, safety and immunogenicity of MB09 versus Prolia® in postmenopausal women with osteoporosis

NCT ID: NCT05322122 Recruiting - Obesity Clinical Trials

Creation of Side-to-Side Compression Anastomosis Using the Magnetic Anastomosis System

Start date: November 18, 2021
Phase: N/A
Study type: Interventional

This is an operationally seamless, open-label, multicenter study enrolling up to 35 subjects with obesity and with or without type 2 diabetes at 5 study centers across Canada and Europe who will undergo sleeve gastrectomy (revision or de novo) with side-to-side anastomosis duodeno-ileostomy using the MAGNET System and will be followed for 12 months.

NCT ID: NCT05315544 Completed - Clinical trials for Coronary Artery Disease

Cardiovascular Systems Inc. (CSI) pVAD First in Human Study

Start date: March 14, 2022
Phase: N/A
Study type: Interventional

This study will collect initial clinical data on the CSI pVAD system to inform device design and finalization.

NCT ID: NCT05295927 Recruiting - Prostatic Neoplasms Clinical Trials

A Study of EPI-7386 in Combination With Abiraterone Acetate Plus Prednisone, or Apalutamide in Metastatic Castration-resistant Prostate Cancer (mCRPC)

Start date: March 23, 2022
Phase: Phase 1
Study type: Interventional

The purpose of this study is to determine safety, including dose limiting toxicities, and the recommended phase 2 dose (RP2D) of EPI-7386 in separate combinations with (a) abiraterone acetate plus prednisone or prednisolone (AAP) and (b) apalutamide (dose-finding) and to determine the antitumor activity of EPI-7386 in separate combinations with (a) AAP and (b) apalutamide (dose-expansion).

NCT ID: NCT05271734 Recruiting - Clinical trials for OAG - Open-Angle Glaucoma

Evaluation of the Compatibility of Different Eye Lid Retractors to the Direct Selective Laser Trabeculoplasty (DSLT) Procedure

Start date: June 6, 2021
Phase: N/A
Study type: Interventional

Direct Selective Laser Trabeculoplasty (DSLT) is an emerging therapeutic technology to treat glaucoma. DSLT was previously tested in 2 clinical trials and demonstrated promising safety and efficacy results in reducing the patient's intra ocular pressure. The GLAUrious pivotal confirmatory RCT (NCT03750201) recently completed enrolment (n=192) and safety and efficacy results are expected in Q1/2022. Experience gained in the previous clinical studies indicates that a full exposure of the limbal area is not easily achieved in all patients with common commercial lid retractors. Patients with narrow palpebral fissures, narrow or floppy eyelids, and patients with deep-set eyes employs a substantial challenge.