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NCT ID: NCT06405022 Completed - Healthy Clinical Trials

Does Sport Specific Brain Endurance Training Enhance Physical and Cognitive Performance in Elite Orienteering Athletes?

Start date: March 1, 2021
Phase: N/A
Study type: Interventional

The purpose of the study is to measure the effects of a 6 week sport specific BET intervention on physical and cognitive performance parameters in elite orienteering athletes.

NCT ID: NCT06403839 Recruiting - Endocarditis Clinical Trials

Impact of Preoperative Dental Screening in Reducing Infective Endocarditis Risk in Surgical Valve Replacement Patients

DENSVAR
Start date: January 1, 2020
Phase:
Study type: Observational

In Odense University Hospital preoperative dental screening (PDS) protocol for patients treated with surgical valve replacement was changed from mandatory to targeted PDS to from march 2024. The investigators will therefore compare the risk of IE before vs after march 2024.

NCT ID: NCT06402838 Recruiting - Alzheimer's Disease Clinical Trials

A Study to Evaluate the Safety and Biomarker Effects of RO7269162 in Participants at Risk for or at the Prodromal Stage of Alzheimer's Disease (AD)

Start date: May 2, 2024
Phase: Phase 2
Study type: Interventional

This clinical trial is recruiting people who either are at risk of AD - have build-up of beta-amyloid, but have no clinical symptoms, or with a diagnosis of mild cognitive impairment. People can take part if they have a certain level of plaques (beta-amyloid) in the brain, shown by a positron emission tomography (PET) scan, a medical imaging technique in which tracers are injected to visualize specific pathological processes in the brain. People who take part in this clinical trial (participants) will be given RO7269162 OR placebo for up to about 1 and a half years. The clinical trial team will see them every 3 weeks in the first 3 months and then every 6 weeks until the end of the trial. These hospital visits will include checks to see how the participant responds to the treatment and any side effects they may have. The total time of participation in the clinical trial will be 90 weeks.

NCT ID: NCT06402799 Recruiting - Cerebral Palsy Clinical Trials

Home-based E-biking Intervention Among Adolescents With Cerebral Palsy

Start date: February 12, 2024
Phase: N/A
Study type: Interventional

Investigation of the feasibility of virtually group-based e-biking training at home. Twenty young individuals aged 13-25 years with CP (Cerebral Palsy) with a Gross Motor Function Classification System score of 1-3 are recruited for a 12-week home-based e-biking training program.

NCT ID: NCT06402409 Recruiting - Neck Pain Clinical Trials

Exploring Multimorbidity in Patients With Spinal Pain

Start date: April 1, 2024
Phase:
Study type: Observational [Patient Registry]

Spinal pain is frequently accompanied by other chronic conditions (multimorbidity) and the predicted rise in multimorbidity prevalence emphasizes the need for studies to understand its impact on patients with chronic pain conditions. Therefore the aims of the two studies are to: Work package 1 - Determine prevalence of multimorbidity among patients with spinal pain referred to hospital outpatient clinics. Examine associations with relevant health-related factors and cover the significance of multimorbidity in the diagnostic process, referral patterns and healthcare utilization. Work package 2: Examine the association between treatment burden arising from multimorbidity and patient prognosis in structured rehabilitation. Across both work packages data will be derived from individuals initially referred to the Department of Rheumatology at Aalborg University Hospital (AaUH) or the Medical Spine Clinic in Silkeborg (MSCS).

NCT ID: NCT06402266 Completed - Clinical trials for Genetic Predisposition

Simultaneous tDCS and Computerised Gamified Short-term Memory Task Feasibility

ACTTDCS-FG
Start date: July 4, 2022
Phase:
Study type: Observational

The goal of this observational study is to gain insight into the effects of transcranial direct current stimulation (tDCS) on short-term memory task performance and the feasibility of tDCS in overtly healthy carriers of the susceptibility allele, Apolipoprotein (APOE) ε4, for late-onset Alzheimers disease. The main questions the study aims to answer are: - If tDCS is feasible in overtly healthy APOE ε4 carriers using a headset and an app-based short-term memory task. - If overtly healthy APOE ε4 carriers perform better on a complex short-term memory task when receiving tDCS to the right hemisphere (F4 à PZ) compared to the left hemisphere (F3 à PZ) or sham tDCS. Participants will be asked to complete an app-based short-term memory task while receiving either tDCS to either the right or left hemisphere or sham stimulation on 3 different days spread out over 1-3 weeks.

NCT ID: NCT06402201 Recruiting - Clinical trials for Select Advanced Solid Tumors

First in Human Study of CDR404 in HLA-A*02:01 Participants With MAGE-A4 Expressing Solid Tumors

Start date: May 24, 2024
Phase: Phase 1
Study type: Interventional

CDR404 is a highly potent and specific T-cell engaging bispecific and bivalent antibody designed for the treatment of cancers positive for the tumor-associated antigen melanoma-associated antigen 4 (MAGE-A4). This is a first-in-human study designed to evaluate the safety, tolerability, and preliminary anti-tumor activity of CDR404 in adult patients who have the appropriate germline human leukocyte antigen HLA-A*02:01 tissue marker and whose cancer is positive for MAGE-A4.

NCT ID: NCT06401616 Recruiting - Atrial Fibrillation Clinical Trials

Can Patients With Atrial Fibrillation Safely Discontinue Anticoagulant Therapy After Cardiac Surgery? (ATLAAC)

Start date: May 21, 2024
Phase: Phase 4
Study type: Interventional

Left atrial appendage (LAA) closure has become a frequent addition to oral anticoagulation in patients with atrial fibrillation who undergo cardiac surgery. The procedure significantly reduces the risk of stroke and systemic embolism, which may render anticoagulation unnecessary or even harmful when considering the associated increased risk of bleeding. A clinical trial to address the need for anticoagulation after LAA closure is needed. The ATLAAC trial will enroll 1220 patients with atrial fibrillation who have previously undergone surgical LAA closure. Patients will undergo a cardiac CT-scan to determine if LAA closure was successful and patients with successful closure will be randomized to continue or discontinue anticoagulation. The trial will assess the risk of ischemic stroke, peripheral arterial embolism, and major bleeding during the randomized intervention

NCT ID: NCT06399978 Not yet recruiting - Clinical trials for Mild Cognitive Impairment

The Feasibility and Effect of Digital Cognitive Training in Mild Cognitive Impairment

Start date: May 6, 2024
Phase: N/A
Study type: Interventional

The goal of this study is to assess the feasibility and effect of digital cognitive training based on the principles of Differential Outcome Training (DOT) in patients with Mild Cognitive Impairment. In DOT training, each stimulus-response pair to be learnt is followed by a unique reinforcer, as opposed to non-DOT (NDOT) training, where the stimulus-response pairs are all followed by a random reinforcer. DOT training is believed to boost learning more than NDOT training through associations. The main questions the study aims to answer are: - Whether at-home, tablet-based digital cognitive training is feasible in elderly patients with Mild Cognitive Impairment - Whether regularly digital cognitive DOT training has a positive effect on patients' cognitive functioning and quality of life - Whether any potential effects that the cognitive DOT training may have on the patients' cognitive functioning are transferable to the patients' daily life. Participation in the study includes: - A pre-training session at the site with the primary project coordinator, where the patient will complete a number of self-report questionnaires about their health, cognition, and quality of life as well as a neuropsychological assessment. - Training with the digital cognitive DOT training program at home for 20 min. per day 3-4 times a week for 6-8 weeks. - A post-training session at the site with the primary project coordinator after the 6-8 weeks have passed, where the patient will complete a usability questionnaire about the training programme, some of the same self-report questionnaires about their health, cognition, and quality of life as well as some of the neuropsychological assessments. - A 1-month follow-up session where the patients will complete some of the same self-report questionnaires again about their cognition and quality of life plus a questionnaire aimed the transferability of any positive cognitive effects of the training.

NCT ID: NCT06399913 Completed - Computed Tomography Clinical Trials

Cerebral Computed Tomography on Patients With Minor Head Injuries

Start date: January 1, 2023
Phase:
Study type: Observational

This observational study aims to calculate the prevalence of conditions or diseases requiring immediate medical attention in CTC scans with an indication of bleeding post trauma performed in the ED at Odense University Hospital. Secondary, we aim to evaluate the Scandinavian Neurotrauma Committee clinical guideline 2013 for minor head injury.