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NCT ID: NCT01303172 Completed - Clinical trials for Advanced Pancreatic Cancer

A Trial Comparing Gemcitabine With and Without IMM-101 in Advanced Pancreatic Cancer

Start date: June 2011
Phase: Phase 2
Study type: Interventional

To compare, in patients with advanced pancreatic cancer, the effects of IMM-101 in combination with gemcitabine to gemcitabine alone on safety and tolerability (including QoL), clinical signs and symptoms of disease, selected markers of tumour burden and immunological status, and disease outcome.

NCT ID: NCT01275872 Completed - Breast Cancer Clinical Trials

Effect of Guided Imagery and Progressive Muscle Relaxation as a Means to Improve the Psychological Well-being and the Quality of Life for Patients With Breast and Prostate Cancer

Start date: April 2010
Phase: N/A
Study type: Interventional

The purpose of this study is to determine whether Guided Imagery and Progressive Muscle Relaxation techniques are effective in the management of pain, fatigue, nausea-vomit, anxiety and depression in patients with either prostate or breast cancer. This study includes a total of 200 patients with prostate and breast cancer randomly assigned to either a control or intervention group. The intervention group received in total 4 sessions of Guided Imagery (protocol floating on a cloud) and Progressive Muscle Relaxation (breathing exercises and use of 11 groups of muscle progressively tensing and relaxing). Measurements included the assessment of pain, fatigue, nausea-vomit, depression, anxiety and quality of life. Additionally, saliva samples were collected prior and after the sessions as to assess saliva cortisol and saliva α-amylase. The same measurements were received by the patients of the control group as to allow comparisons.

NCT ID: NCT01229787 Completed - Clinical trials for Asthma, Allergies and Obesity

The Relation Between Obesity, Adipose Tissue Content of Fatty Acids and Systemic and Airway Inflammation

Start date: January 2007
Phase: N/A
Study type: Observational

Obesity has been recognized as a risk factors for developing asthma. In a cohort of 5384 children aged 15-17, we aim to: 1. To investigate the association of asthma prevalence at age 15-17 with body mass index (BMI) at age 15-17 and BMI at age 11-12 years Part II 2. To investigate the association of BMI in adolescence and BMI at age 11-12 years with: 1. Prevalence of allergic sensitization 2. Lung function 3. Levels of airway inflammation at age 16-18 years 4. Severity of asthma Secondly, to assess diet and physical activity involvement as effect modifiers in these possible associations.

NCT ID: NCT01203605 Completed - Non-cardiac Surgery Clinical Trials

European Surgical Outcomes Study

EuSOS
Start date: April 2011
Phase: N/A
Study type: Observational

The European Surgical Outcomes Study (EuSOS) is a multi-centre, international cohort study of peri-operative care and clinical outcomes for patients undergoing non-cardiac surgery. Participating centres throughout Europe will contribute routine clinical data describing all eligible patients who undergo surgery from 4th April 2011 to 11th April 2011. Patients will then be followed until hospital discharge (or for a maximum of 60 days) for duration of hospital stay and hospital mortality. Routine clinical data will also be collected for those patients admitted to critical care at any stage after surgery but during the same hospital admission. Specific objectives are to describe clinical outcomes and standards of peri-operative care for patients undergoing non-cardiac surgery in Europe.

NCT ID: NCT00988429 Completed - Partial Epilepsy Clinical Trials

Efficacy and Safety of Eslicarbazepine Acetate (BIA 2-093) as Adjunctive Therapy for Refractory Partial Seizures

Start date: December 2, 2008
Phase: Phase 3
Study type: Interventional

The purpose of this study is to determine whether Eslicarbazepine acetate (BIA 2-093) is an effective adjunct therapy in the treatment of refractory partial seizures

NCT ID: NCT00831714 Completed - Clinical trials for Venous Thromboembolism

Xarelto for VTE Prophylaxis After Hip or Knee Arthroplasty

XAMOS
Start date: February 2009
Phase: N/A
Study type: Observational

The main goal is to provide additional information to the risk-benefit assessment of the drug.

NCT ID: NCT00640081 Completed - Colorectal Cancer Clinical Trials

Combination Chemotherapy and Cetuximab as First-Line Therapy in Treating Patients With Advanced and/or Metastatic Colorectal Cancer

Start date: July 2007
Phase: Phase 2
Study type: Interventional

RATIONALE: Drugs used in chemotherapy work in different ways to stop the growth of tumor cells, either by killing the cells or by stopping them from dividing. Monoclonal antibodies, such as cetuximab, can block tumor growth in different ways. Some block the ability of tumor cells to grow and spread. Others find tumor cells and help kill them or carry tumor-killing substances to them. It is not yet known whether giving combination chemotherapy together with intermittent cetuximab is more effective than combination chemotherapy given together with continuous cetuximab in treating colorectal cancer. PURPOSE: This randomized phase II trial is studying giving combination chemotherapy together with intermittent cetuximab to see how well it works compared to combination chemotherapy given together with continuous cetuximab as first-line therapy in treating patients with advanced or metastatic colorectal cancer.

NCT ID: NCT00628745 Completed - Clinical trials for Transthyretin Amyloidosis

Transthyretin Amyloidosis Outcome Survey (THAOS)

THAOS
Start date: January 4, 2008
Phase:
Study type: Observational

THAOS is a global, multi-center, longitudinal observational survey open to all patients with transthyretin amyloidosis (ATTR), including ATTR-PN (polyneuropathy), ATTR-CM (cardiomyopathy) and wild-type ATTR-CM. It is open-ended with a minimum duration of 10 years. Patients will be followed as long as they are able to participate. The principal aims of this outcome survey are to better understand and characterize the natural history of the disease by studying a large and heterogenous patient population. Survey data may be used to develop new treatment guidelines and recommendations, and to inform and educate clinicians about the management of this disease.

NCT ID: NCT00600938 Completed - Clinical trials for Transfusional Iron Overload

Evaluating Use of Deferasirox as Compared to Deferoxamine in Treating Cardiac Iron Overload

CORDELIA
Start date: November 2007
Phase: Phase 2
Study type: Interventional

This is a clinical research study in patients who have iron overload in the heart due to chronic blood transfusions. The study will have 2 treatment groups and will compare the safety and efficacy of chelation therapy with a medicine called deferasirox (ICL670) with another medicine called deferoxamine (DFO). The study is aimed at finding out which of the two medicines is the best for treating iron overload in the heart. Patients will be treated for 12 months (core study phase). Patients who complete the core study phase will be offered to continue their study treatment in a 12 months extension phase. During the core and extension, the effects of treatment on iron overload in the heart and the liver will be evaluated using specific magnetic resonance imaging (MRI) assessments.

NCT ID: NCT00567502 Completed - Clinical trials for Thrombocythemia, Essential

Safety and Pregnancy Outcomes in Thrombocythemia Patients Exposed to XAGRID® (Anagrelide Hydrochloride) Compared to Other Treatments

Start date: May 31, 2005
Phase:
Study type: Observational

This is an observational safety study being conducted in Europe comparing patients taking Xagrid to patients taking other cytoreductive treatments. The plan is to enrol at least 750 subjects taking Xagrid with up to 3000 subjects taking other cytoreductive therapies. The study will collect follow up data for 5 years for each patient enrolled that will focus on collecting data related to pre-defined events (PDEs) and Suspected Serious Adverse Reactions (SSARs).