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NCT ID: NCT03211559 Completed - Clinical trials for Ankylosing Spondylitis

Clinical Pilates and Aerobic Exercise in Patients With Ankylosing Spondylitis

Start date: October 2015
Phase: N/A
Study type: Interventional

The aim of our study is to investigate the effect of Clinical Pilates Exercises on functional status and quality of life when applied together with aerobic exercise in patients with ankylosing spondylitis (AS).

NCT ID: NCT03198273 Recruiting - Clinical trials for Lumbar Disc Herniation

The Efficacy of Clinical Pilates Exercises on Individuals With Lumbar Disc Herniation

Start date: May 1, 2017
Phase: N/A
Study type: Interventional

The aim of the study is to determine the effects of clinical Pilates Exercises on the level of pain, functional status, flexibility, static and dynamic endurance of the truncus muscles and quality of life in patients with lumbar disc herniation.

NCT ID: NCT03129100 Recruiting - Clinical trials for Axial Spondyloarthritis

A Long Term Extension Study of Ixekizumab (LY2439821) in Participants With Axial Spondyloarthritis

Start date: April 19, 2017
Phase: Phase 3
Study type: Interventional

The purpose of this study is to evaluate, in participants having achieved a state of sustained remission, if the ixekizumab treatment groups are superior to the placebo group in maintaining response during the randomized withdrawal-retreatment period in participants with axial spondyloarthritis.

NCT ID: NCT03121222 Completed - Clinical trials for Glutathione Metabolism Anemias

The Effects of N-acetylcysteine on Performance and Redox Homeostasis

Start date: November 1, 2015
Phase: Phase 2
Study type: Interventional

The main objective of the present study was to investigate whether N-acetylcysteine supplementation in individuals with low glutathione levels would confer ergogenic effects by replenishing glutathione levels and by reducing oxidative stress. Towards this aim, investigators sought to exploit the large inter-individual variability in redox biomarker levels. More specifically, investigators screened 100 male participants for glutathione baseline levels in blood and formed three stratified groups according to this value (i.e., low, moderate and high; 12 individuals per group). After by-passing the regression to the mean artefact by performing a second glutathione measurement in the three aforementioned groups, investigators assessed both aerobic and anaerobic physical performance in order to acquire a more comprehensive view about the ergogenic effectiveness of the antioxidant treatment. This was accomplished by implementing three different whole-body physical performance tests (i.e., VO2max test, time trial and Wingate), as opposed to most in vivo studies that either applied isolated body-part exercise tests (e.g., by isokinetic dynamometry) or performed a single exercise test (e.g., time-to-fatigue test). It was hypothesised, that data of the present investigation will bridge the chasm between the scientific (i.e., chronic antioxidant supplementation blunts exercise performance and adaptations) and the community-based (i.e., free radicals should anyway be counteracted by "protective" exogenous antioxidants) truths about the role of antioxidants as ergogenic aids. It was also hypothesised that the results will show that low glutathione levels are linked to decreased aerobic and anaerobic physical performance accompanied by increased levels of oxidative stress and that N-acetylcysteine supplementation will restore both performance and redox homeostasis. Based on the findings of the present investigation, the widespread routine practice of consuming antioxidants during exercise training could be changed and the consumption of antioxidants would be restricted only for those who are deficient in glutathione.

NCT ID: NCT02991781 Not yet recruiting - Asthma Clinical Trials

Combined Bio- and Neuro- Feedback vs. Varenicline Use for Smoking Cessation

Start date: January 2017
Phase: N/A
Study type: Interventional

This study will develop and experimentally test the efficiency of a neurofeedback training protocol vs. varenicline use for smoking cessation.

NCT ID: NCT02962505 Recruiting - Clinical trials for Acute Respiratory Distress Syndrome

Continuous Regional Analysis Device for Neonate Lung

CRADL
Start date: November 2016
Phase: N/A
Study type: Observational

The purpose of the study is to assess whether Electrical Impedance Tomography (EIT) has the potential to optimize the ventilator therapy, validate the effectiveness, efficacy and safety of nursing and medical interventions (endotracheal suctioning, posture changes, surfactant therapy, recruitment manoeuvres, etc.) and for early recognition of complications like pneumothorax and endotracheal tube misplacement. The study design is purely observational.

NCT ID: NCT02734992 Active, not recruiting - Headache Clinical Trials

Acceptance and Commitment Therapy vs Medical Treatment as Usual Wait-list Control for Primary Headache Sufferers

ALGEA
Start date: September 2014
Phase: N/A
Study type: Interventional

Research to date suggests that individuals with headache use avoidance as a way to manage their pain. Despite the wide use of avoidance as a coping mechanism of headache triggers, very little empirical evidence exist to support its effectiveness in headache management. New treatment approaches, such as Acceptance and Commitment Therapy (ACT), emphasize acceptance of headache and valued-living as alternatives to avoidance, have demonstrated preliminary support in helping individuals reduce headache-related disability and improve quality of life. Though, ACT has received empirical support for various chronic pain conditions, very little evidence exists as to its effectiveness for head pain problems. The current study will examine the effects of an ACT-based intervention when added to medical treatment as usual (MTAU) vs. a wait list control group comprised only of MTAU, on improving quality of life and decreasing disability among headache sufferers.

NCT ID: NCT02705820 Recruiting - Clinical trials for Metastatic Non Small Cell Lung Cancer

Switch Maintenance Pembrolizumab in Patients With NSCLC After First Line Platinum Doublet Chemotherapy

SWIPE
Start date: April 2016
Phase: Phase 2
Study type: Interventional

Single arm one stage Phase II study: post 4-6 cycles platinum doublet chemotherapy for patients with metastatic Non Small Cell Lung Cancer (NSCLC) offering Pembrolizumab as maintenance therapy to non-progressors with primary endpoint: Immune Related Progression Free Survival (irPFS) at 1 year. Aim to show that this is at least 25% (compared to an expected 12% 1 year PFS based on the Pemetrexed and Erlotinib maintenance trials).

NCT ID: NCT02625415 Recruiting - Clinical trials for Palmar-Plantar Erythrodysesthesia

The Topical Application of Vitamin B6 in Palmar-Plantar Erythrodysesthesia

HFSB6
Start date: July 2016
Phase: N/A
Study type: Interventional

The study is designed to test the effectiveness of topical B6 cream in patients that developed Palmar-Plantar Erythrodysesthesia (Hand foot syndrome).

NCT ID: NCT02595762 Recruiting - Clinical trials for Metastatic Breast Cancer

A Study of Treatment Patterns and Outcomes in Participants With Human Epidermal Growth Factor Receptor 2 (HER2)-Positive Unresectable Locally Advanced or Metastatic Breast Cancer

Start date: October 30, 2016
Phase: N/A
Study type: Observational

This disease registry is a prospective, multicenter non-interventional study designed to observe anti-cancer treatment regimens and clinical outcomes in participants with HER2-positive unresectable locally advanced breast cancer (LABC) or metastatic breast cancer (MBC).