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NCT ID: NCT06452147 Not yet recruiting - Anesthesia Clinical Trials

Anesthesia and Perioperative Neurocognitive Disorders in the Elderly Patients Undergoing Hip Fracture Surgery Platform Trial (ANDES Platform Trial)

ANDES platform
Start date: June 30, 2024
Phase: N/A
Study type: Interventional

Anesthesia and perioperative Neurocognitive Disorders in the Elderly patients undergoing hip fracture Surgery platform trial (ANDES platform trial): A pragmatic multi-arm, adaptive, open label, multicenter randomized controlled platform trial to assess the effect of different enhance anesthesia technique in perioperative neurocognitive function, as compared to standard anesthesia care in the elderly patients undergoing hip fracture

NCT ID: NCT06451887 Recruiting - Ischemic Stroke Clinical Trials

Early Identification of Malignant Brain Edema in laRge Artery oCclusive Stroke After Endovascular Therapy (EMBRACE Study)

EMBRACE
Start date: April 1, 2024
Phase:
Study type: Observational [Patient Registry]

To design and validate a predictive model for malignant brain edema after endovascular thrombectomy.

NCT ID: NCT06451861 Not yet recruiting - Clinical trials for Acute Myeloid Leukemia

Randomized Study of ABC-14 Regimen Compared With "3+7" Standard Induction Therapy or AB-14 for ND AML

Start date: May 31, 2024
Phase: Phase 2
Study type: Interventional

To compare the efficacy and safty of ABC-14 regimen with the traditional "3+7" regimen or AB-14 regimen in the treatment of newly diagnosed acute myeloid leukaemia

NCT ID: NCT06451848 Recruiting - Clinical trials for Gouty Arthritis (GA)

A Bioequivalence Study of Two Different Dosage Form of Genakumab

Start date: June 29, 2024
Phase: Phase 1
Study type: Interventional

The purpose of this study is to investigate whether Genakumab Injection is bioequivalent to Genakumab for Injection.

NCT ID: NCT06451783 Enrolling by invitation - Clinical trials for Osteoarthritis of the Knee

Shengyu Decoction and Lijin Manipulation for Knee OA: 3D Gait Analysis

Start date: May 1, 2024
Phase: Early Phase 1
Study type: Interventional

Detailed Description Avoid duplicating information that will be entered or uploaded elsewhere in the record.

NCT ID: NCT06451640 Not yet recruiting - Clinical trials for Chronic Rhinosinusitis With Nasal Polyps

A Extension Clinical Study of TQC2731 Injection in the Treatment of Chronic Sinusitis With Nasal Polyps

Start date: June 2024
Phase: Phase 2
Study type: Interventional

This study aims to evaluate the efficacy and safety of TQC2731 injection in the treatment of chronic sinusitis with nasal polyps.

NCT ID: NCT06451627 Recruiting - Sleep Disturbance Clinical Trials

Esketamine on Postoperative Sleep Disturbance of Patients Undergoing Spinal Surgery

Start date: June 10, 2024
Phase: N/A
Study type: Interventional

The goal of this clinical trial is to learn about the effect of intraoperative esketamine infusion on postoperative sleep disturbance(PSD) of patients undergoing spinal surgery. The main aims to answer are: - To explore the effect of intraoperative infusion of esketamine on the incidence of postoperative sleep disturbance and sleep quality in patients undergoing spinal surgery. - To explore the effect of intraoperative infusion of esketamine on postoperative pain, anxiety and depression ; Participants will be patients undergoing spinal surgery with general anesthesia at Beijing Tiantan Hospital. 0.3mg/kg/h esketamine or saline will be infused during surgery . The incidence of sleep disturbance , sleep quality, pain scores, hospital anxiety and depression scores and perioperative adverse events after surgery will be investigated.

NCT ID: NCT06451393 Recruiting - Gastric Cancer Clinical Trials

Predicting Gastric Cancer Response to Chemo With Multimodal AI Model

Start date: February 1, 2013
Phase:
Study type: Observational

This study aims to develop a multimodal model combining radiomic and pathomic features to predict pathological complete response (pCR) in advanced gastric cancer patients undergoing neoadjuvant chemotherapy (NAC). The researchers intended to collected pre-intervention CT images and pathological slides from patients, extract radiomic and pathomic features, and build a prediction model using machine learning algorithms. The model will be validated using a separate cohort of patients. This research intend to build a radiomic-pathomic model that can outperform models based on either radiomic or pathomic features alone, aiming to improve the prediction of pCR in gastric cancer.

NCT ID: NCT06451302 Active, not recruiting - Ewing Sarcoma Clinical Trials

Risk Stratification Oriented Treatment of Pediatric Ewing Sarcoma: a Prospective Multicenter Cohort Study

Start date: April 17, 2024
Phase: N/A
Study type: Interventional

The aim is to evaluate the outcome and safety of risk-stratification oriented treatment for pediatric Ewing sarcoma in multicenters .

NCT ID: NCT06451211 Recruiting - Gastric Cancer Clinical Trials

Neoadjuvant Immunotherapy Plus Chemotherapy in Borrmann Type 4 and Large Type 3 Gastric Cancer

Neo-ICEBOAT
Start date: May 17, 2023
Phase: Phase 2
Study type: Interventional

The aim of this study is to test the efficacy and safety of immunotherapy plus chemotherapy on people with a relatively rare type of gastric cancer. Participants will take the anti-PD-1 inhibitor (Tislelizumab) and platinum-based chemotherapy (oxaliplatin + capecitabine or oxaliplatin + S-1) in a 3-week cycle, followed by a radical operation after 6 cycles.