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NCT ID: NCT05431725 Not yet recruiting - Seasonal Influenza Clinical Trials

Immunogenicity and Safety Study of Influenza Vaccine (Split Virion), Inactivated, Quadrivalent in Chile

Start date: July 1, 2022
Phase: Phase 3
Study type: Interventional

The purpose of this study is to evaluate the safety and immunogenicity of Influenza vaccine (Split virion), Inactivated, Quadrivalent developed by Sinovac Biotech Co., Ltd. (Sinovac-QIV) as compared to a licensed comparator in Chile, Vaxigrip Tetraâ„¢ (Vaxigrip Tetra-QIV) in individuals aged 3 years and older.

NCT ID: NCT05425069 Recruiting - Aging Problems Clinical Trials

Evaluation of the EEG Connectivity Using Predominant Dexmedetomidine as Anesthetic in Fragile Brains

BaseDexmed
Start date: January 2, 2022
Phase:
Study type: Observational [Patient Registry]

Elderly brains that present a lower intrinsic cortical activity are very dependent on arousal feeding. In these patients, a strong blockade of afferences generates a synchronic state with a high tendency to sleep. This is done with drugs such as Dexmedetomidine and its indirect effect of inhibiting the amplification of signals and opioids such as remifentanil. Then, by adding a micro-dose of a gabaergic substance to induce loss of consciousness, unconsciousness would be maintained due to the low requirement of a fragile and synchronous brain by a slow continuous injection of an alpha2 agonist. In previous experience, doses of about one-fifth of the usual would be sufficient to maintain unconsciousness (or perhaps disconnected consciousness that could be useful in avoiding excessive depression in slowed integration pathways). These patients also present deficits in the orexinergic response that manifest themselves in greater neuronal inertia and delayed awakening. Gabaergic drugs (propofol and sevoflurane) are especially depressing to orexinergic nuclei. This approach to the elderly brain could have an impact on recovering more easily connectivity of those CNC networks. In elderly patients, one aspect that could control the phenomena of altered connectivity and its impact in developing delirium is the limitation of connection with the environment before the capacity of integration of cortical information has been completely recovered. To analyze frontoparietal connectivity, front frontal coherence, phase lag index, or similar it is necessary to a multichannel EEG (e.g. 10 channels). Otherwise, the frontal EEG from the SEDline monitor device allowed to analyze only spectral characteristics (power, peak frequency, etc.) and correlate them with clinical observations (MoCA).

NCT ID: NCT05416788 Completed - Bruxism Clinical Trials

Effect of Cervical Manipulation on Mouth Opening

Start date: May 11, 2022
Phase: N/A
Study type: Interventional

Objectives: To compare the effects of cervical manipulation on the ranges of motion of mouth opening and painful pressure points in the masseter and temporal muscles after of cervical manipulation compared to the control group. Material and methods: Single-blind randomized clinical trial with two arms, one group intervention and a control group. Hypothesis: There is a significant difference in mouth opening and painful pressure points between the intervention group and the control group. Expected results: The intervention group would significantly increase their mouth opening maximal and decrease pressure pain in the masseter and temporalis muscles.

NCT ID: NCT05408442 Recruiting - Clinical trials for Mechanical Ventilation

Role of Pulmonary Perfusion on Tolerance to Supine Position in Patients With ARDS

Start date: July 1, 2021
Phase:
Study type: Observational [Patient Registry]

The relationship between the presence or absence of endothelial dysfunction and changes in pulmonary perfusion will be evaluated, to then determine if there is any association between changes in the V / Q ratio and tolerance to the supine position after a prone cycle in patients with acute respiratory distress syndrome on mechanical ventilation.

NCT ID: NCT05403996 Not yet recruiting - Health Behavior Clinical Trials

Effects of an Active Break Program at Primary School

Activa-Mente
Start date: July 1, 2022
Phase: N/A
Study type: Interventional

The purpose of this study is to assess the effectiveness of an active break program at school on physical activity levels and enjoyment, and on-task behavior in children.

NCT ID: NCT05403788 Completed - Parkinson Disease Clinical Trials

Usability Study of a Neuropsychological Intervention Program Based on Virtual Reality in Adults With Parkinson's Disease

Start date: March 1, 2021
Phase: N/A
Study type: Interventional

Nowadays, several strategies for treating neuropsychologic function loss in Parkinson disease (PD) have been proposed, such as physical activity performance and developing games to exercise the mind. However, few studies illustrate the incidence of these therapies in neuronal activity. This work aims to study the feasibility of a virtual reality-based program oriented to the cognitive functions' rehabilitation of PD patients. For this, the study was divided in intervention with the program, acquisition of signals, data processing and results analysis. The study highlights implementing new technologies to rehabilitate people with neurodegenerative diseases.

NCT ID: NCT05399758 Not yet recruiting - Nociceptive Pain Clinical Trials

Nociception Evaluated by the NOL® Index in Sedated Patients in the Intensive Care Unit

Start date: June 1, 2022
Phase:
Study type: Observational

Due to their underlying pathology and the necessary complicated procedures to which they are exposed, patients in the intensive care unit experience varying degrees of pain at some point in their evolution. Evidence has established short-term and long-term negative consequences of unresolved pain or excessive analgesic sedation. However, pain assessment or adequate nociceptive monitoring remains a significant challenge, especially in non-communicative patients under deep sedation, who urgently need to expand and improve current tools. Pain assessment in critically ill patients is challenging; limitations in their ability to communicate (neurocognitive deficit, use of endotracheal tube) or altered consciousness (deep sedation) make them unable to self-report their pain with standard pain scales. The Behavioral Pain Scale (BPS) and the Critical-Care Pain Observation Tool (CPOT) are the pain assessment tools with the best performance and reliability for patients in these conditions. Different technologies are used to monitor nociceptive responses caused by surgical stress in patients under general anesthesia that together with the clinical evaluation, manage to keep patients in the best analgesic conditions, improving the post-surgical prognosis. In particular, the NOL® nociceptive index (Medasense, Ramat Gan, Israel) is a multiparametric detection of nociception/pain, delivering a dimensionless score (0 -100) calculated through an algorithm (patented) and based on the registry of four biometric sensors (photoplethysmography, galvanic skin response, temperature, and accelerometer). NOL index value between 10-25 is the most appropriate for maintaining analgesia during general anesthesia. The ease and low invasiveness of this system (all sensors are implemented in a finger clip, similar to an oxygen saturation monitor) may allow its potential use in the context of intensive care unit patients. Some studies have recently been published that highlight the possible usefulness of the NOL® index in critically ill patients. However, in these studies, the assessment of nociception was limited to acute nociceptive procedures only.

NCT ID: NCT05398263 Not yet recruiting - Asthma Clinical Trials

Tezepelumab Efficacy and Safety in Reducing Oral Corticosteroid Use in Adults With Oral Corticosteroid Dependent Asthma

SUNRISE
Start date: June 9, 2022
Phase: Phase 3
Study type: Interventional

A Randomised, Double-Blind, Parallel-Group, Placebo-Controlled 40-week Phase 3 Efficacy and Safety Study of Tezepelumab in Reducing Oral Corticosteroid Use in Adults with Oral Corticosteroid Dependent Asthma

NCT ID: NCT05396365 Completed - Hand Grasp Clinical Trials

Hand Grip Strength in Chilean Adults

Start date: May 1, 2018
Phase:
Study type: Observational

Context Hand grip strength (HGS) is an important parameter to assess hand function during the rehabilitation of hand injuries. HGS serves as a clinical predictor of complications after surgery. Purpose Establish HGS reference values in healthy adult Chilean population. Study design analytical cross-sectional. Method 311 healthy women and men, ages 18 to 65 years participated in the study. HGS was measured with a dynamometer, according to the American Society of Hand Therapists protocol. Additionally, anthropometric and labour characteristics were registered. Kruskal-Wallis test, Wilcoxon-Mann-Whitney test and multiple linear regression were used for data analysis. Significance was set at .05. Results Median HGS in women was 26 kg and 43 kg for men. Men demonstrated 3% more HGS on the dominant versus non-dominant hand. Women's median HGS was no different between dominant versus non-dominant hand. In men and women, manual labour activity was associated with a higher HGS. The relationships between subject anthropometric measurements and HGS were different in women versus men. Conclusions This study determined HGS in Chilean healthy adults. Results can be used as a reference standard for clinical measures related to illness, injury and rehabilitation.

NCT ID: NCT05395806 Active, not recruiting - Hypertension Clinical Trials

Reducing Cardiovascular Risk in Primary Care: a Randomized Clinical Trial

Misalud
Start date: January 1, 2021
Phase: N/A
Study type: Interventional

Cardiovascular disease is a leading cause of death and disease in Chile. It explains 27.6% of the causes of death and 14% of disabled adjusted life years in the Chilean population. Low levels of physical activity and low levels of adherence to pharmacological therapy are major risk factors for cardiovascular disease in at-risk populations. This project will design and test the effectiveness of a mobile application based on gamification theory for improving cardiovascular disease control in a population of 900 primary care patients with moderate or high cardiovascular risk levels. A randomized controlled trial was designed to test the effect of the App in improving 30% of the levels of physical activity and adherence to pharmacological therapy and a significant reduction of 20% in cardiovascular risk levels.