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NCT ID: NCT03636386 Active, not recruiting - Clinical trials for Myofascial Trigger Point Pain

Percutaneous Microelectrolysis in the Reduction of Myofascial Trigger Points Pain

Start date: May 23, 2018
Phase: N/A
Study type: Interventional

The aim of the design is to investigate the value of percutaneous microelectrolysis (MEP) as an analgesic technique in myofascial trigger points. This research seeks to evaluate the influence of the polar effects of the cathode on the reduction of the threshold of painful pressure and intensity of pain in the myofascial trigger points of the trapezius muscle. An assessment with algometry and visual analog scale will be made in healthy subjects before applying the intervention. The study will evaluate the changes in kilograms per square centimeter of painful pressure threshold and millimeters of pain in a group exposed to the application to percutaneous microelectrolysis (MEP) compared to another group that will not receive the intervention. Both groups will be provided with a basic treatment of therapeutic ultrasound. The treatment will include three sessions with an interval of 3 days. Subsequently, the researchers will proceed to compare the painful pressure threshold and pain intensity obtained from the algometry test and visual analogue scale in each of the groups, and between groups, before and after the procedure. The changes obtained between sessions will be compared.

NCT ID: NCT03635138 Not yet recruiting - Caries, Dental Clinical Trials

Effect of the Incoportation of Copper and Zinc Nanoparticles Into Dental Adhesives

1170575
Start date: December 1, 2018
Phase: N/A
Study type: Interventional

The hypothesis is that Addition of copper or zinc nanoparticles to a dental adhesive confers antimicrobial and enzymatic degradation-resistant properties, retaining its adhesion mechanical properties and biocompatibility. To corroborate this hypothesis two groups of a dental adhesive doped with copper or zinc nanoparticles should be develop with a respective structural characterization by SEM-EDX, AFM and FTIR. This should be followed by a test of the antimicrobial activity of adhesive and a study of the influence of adhesive nanocomposites on matrix metalloproteases levels and/or activity in vitro to determine some concentrations more relevant. These would proceed to next stage. With the selected adhesive doped concentrations should be evaluate mechanical properties of doped adhesives and assess the biocompatibility by assays in primary cultured gingival fibroblast and cells type odontoblasts. Finally, once the concentration of either Cu- or Zn-doped adhesives is known, these will be evaluated with a clinical design phase in an in vivo model to study antimicrobial properties, matrix metaloproteases levels and/or activity. We will also study biocompatibility of adhesive nanocomposites and mechanical properties to corroborate the in vitro and ex vivo properties determined. There are results using copper nanoparticle on biomaterials that corroborates some properties such as antimicrobial activity against various species and copper release. All the evidence suggests that at low concentrations of copper nanoparticles, there are no significant effects on mechanical properties but with added antibacterial properties on the adhesive

NCT ID: NCT03629288 Completed - Periodontitis Clinical Trials

Efficacy of Azithromycin as an Adjunct to Non-Surgical Periodontal Treatment

Start date: January 1, 2015
Phase: N/A
Study type: Interventional

This study evaluates the effect of the systemic administration of azithromycin as a therapy associated with non-surgical periodontal treatment, in the clinical and microbiological variables of patients with Moderate Periodontitis with moderate rate of progression (Stage II grade B) and Severe Periodontitis with potencial for additional tooth loss and moderate rate of progression (Stage III grade B). A double-blind, randomized, controlled trial was conducted with 18 voluntary patients with a history of moderate to severe chronic periodontitis, who met the inclusion and exclusion criteria and signed an informed consent. The intervention group received Scaling and Root Planning (SRP) plus azithromycin, and the control group received SRP plus placebo. Probing depth (PD), Clinical Attachment Level (CAL), Biofilm Index (BI) and Bleeding on Probing (BOP) were evaluated as clinical variables while Porphyromonas gingivalis (Pg), Tannerella forsythia (Tf), Treponema denticola (Td), Fusobacterium nucleatum (Fn) were the microbiological variables detected by conventional Polymerase chain reaction (PCR).

NCT ID: NCT03614052 Recruiting - Urolithiasis Clinical Trials

Tamsulosin as Adjuvant Treatment Prior to Endoscopic Ureterolithotomy

Start date: June 1, 2018
Phase: Phase 4
Study type: Interventional

This a study aiming to compare treatment with tamsulosin versus placebo in patients undergoing endoscopic treatment for urolithisis. The main outcome is the rate of stone free patients.

NCT ID: NCT03614013 Active, not recruiting - Clinical trials for Metastatic Gastric Cancer

Resistance to Immunotherapy in Gastric Cancer

MERIT
Start date: July 4, 2018
Phase:
Study type: Observational

This project seeks to analyze and define the mechanism (s) involved in the resistance to checkpoint therapy in metastatic GC patients. The investigators propose the use of a Next-Generation Sequencing (NGS) assay that involves 395 genes allowing us to define a specific molecular signature to characterize responder and non-responder patients to checkpoint therapy in combination with IHC analyses of specific factors. Such signature (s) could then be used to predict which individuals who might get the most benefit out of checkpoint therapy treatment. Analysis will be perfomed retrospectively using biopsies provided by mGC patients recruited at the Red de Salud UC treated with checkpoint therapy, the response of patients to treatment is evaluated by RECIST 1.1 criteria and thereby they are classified as "responders" or "non-responders".

NCT ID: NCT03610893 Not yet recruiting - Pain, Postoperative Clinical Trials

Dexamethasone Versus Dexmedetomidine as Adjuvants for Nerve Blocks

Start date: August 1, 2018
Phase: N/A
Study type: Interventional

When used as perineural (PN) adjuvants to local anesthetics (LAs), dexamethasone (DX) and dexmedetomidine (DXD) have been well documented to prolong the duration of peripheral nerve blocks. These drugs have important differences in terms of cost and safety profiles. This randomized controlled trial (RCT) will compare PN DX and PN DXD for ultrasound-guided infraclavicular brachial plexus blocks (ICBs). Since analgesic and sensory duration can be influenced by factors different to block, motor block duration is the main outcome. The protocol is designed as an equivalency trial and hypothesize that both drugs result in similar durations. The equivalency margin is set at 3 hrs.

NCT ID: NCT03588832 Enrolling by invitation - Stroke Clinical Trials

Prevalence of Postural Patterns of Upper Extremity.

Patterns
Start date: June 1, 2018
Phase:
Study type: Observational

A high number of patient with stroke develops spasticity of the upper extremity, this clinical sign of damage of 1 motoneuro (MN), causes postures and patterns of abnormal movement, due to the hyperexcitability of the MN and the rheological alterations that occur in the affected muscles. These alterations limit the use of upper extremity, restricting its use in functional activities and affecting the quality of life and social participation of the users. During the last few years the classification of the Hefter patterns for spasticity of the upper limb was created, with the end of having a common language and orienting the current therapeutic strategies oriented towards the arm. Objective: To determine the prevalence of patterns and their impact on the quality of life of patients after a stroke. Material and method: Descriptive design of cross section, the sample will be composed of 600 people who attend integral rehabilitation center of regions V, VIII, IX and X in Chile, that meet the inclusion criteria and sign the informed consent. The study will include a measurement made by a trained professional from each participating center using a registration form, the FIM scale and the Barthel index, to assess quality of life. Results: It will be analyzed with the SPSS software through descriptive and inferential statistics considering the nature of the variables, all the analyzes will consider as statistically significant the results with p values less than or equal to 0.05. Depending on the interval or ordinal level of the measurements, the coefficients r of Pearson and rho of Spearman will be used to calculate the correlations. Applicability: The results will determine the prevalence in this geographical sector, disseminate this classification and promote the use of a common language among professionals to enhance their daily work. In addition, it will allow to determine how the affectation of the upper extremity through the identification of a certain pattern alters the quality of life of the patient. This new information can be a fundamental input in the generation of future studies that seek to guide in relation to the use of therapeutic strategies in these people.

NCT ID: NCT03576196 Completed - Clinical trials for Carpal Tunnel Syndrome

Preoperative Pain Neuroscience Education in Patients With Carpal Tunnel Syndrome

Start date: June 1, 2017
Phase: N/A
Study type: Interventional

Study Design: A double-blind randomized controlled study. Background: Patients operated on for carpal tunnel release surgery may persist with pain after surgery, which could be modulated by psychosocial factors such as depression, catastrophic thinking and kinesiophobia. Objectives: To evaluate the efficacy of a preoperative session in pain neuroscience education combined with postoperative therapeutic exercise in the perception of pain, functionality and psychosocial variables in patients following carpal tunnel release. Methods: Thirty participants were randomly assigned to the pain neuroscience education group combined with postoperative therapeutic exercise (n = 15) or to the control group with preoperative usual care combined with postoperative therapeutic exercise (n = 15). Evaluations included the Visual Analogue Scale (VAS), Disability of Arm, Shoulder, and Hand Questionnaire (QuickDASH), pain Catastrophizing Scale (PCS), Tampa scale of kinesiophobia (TSK-11) and Hospital Anxiety and Depression Scale (HADS) . A basal, fourth and twelfth week measurement was made.

NCT ID: NCT03573843 Recruiting - Delirium in Old Age Clinical Trials

Software-guided Cognitive Stimulation to Prevents Delirium

Prevedel
Start date: June 15, 2018
Phase: N/A
Study type: Interventional

This study is a pilot randomized controlled trial, comparing a group of older patients with standardized non-pharmacological delirium prevention plus a basic tablet versus a group with standardized non-pharmacological delirium prevention plus a tablet with a software of cognitive stimulation (PREVEDEL). Software:It is a local development, including a interprofessional team of delirium healthcare experts, older patients and a team og engineers. The software was developed during the first year of this project and was inscribed for author rights. Inclusion criteria: Older patients > 65 y.o. Admitted to medicine room or intermediate care unit > 48 hrs, and informed consent to participate. Exclusion Criteria:Delirium positive, neuroleptic use, dementia, and non-spanish speakers. The study was approved by ethical committee of Hospital Clinico University of Chile Standardized Non-pharmacological intervention: Health workers were previously educated in delirium, and environmental issues were implemented. This intervention coverage in nine different domains: orientation, early mobilization, environmental noise and light, sensorial deficit, sleep, hydratation, drug reduction, and family participation. Intervention: All patients will have a tablet with or without the software PREVEDEL between 09:00-19:00 hrs. Measures: delirium will be monitoring with CAM (Confusion Assessment Method) twice a day for 5 days. Primary outcome: Delirium rate between both groups Secondary outcomes:Long of stay, severity od delirium, time of use of electronic device, and Barthel to discharge.

NCT ID: NCT03573336 Recruiting - Endometriosis Clinical Trials

Assess Safety and Efficacy of Vilaprisan in Subjects With Endometriosis

VILLENDO
Start date: July 4, 2018
Phase: Phase 2
Study type: Interventional

The primary objective of this study is to assess the efficacy and safety of two doses of vilaprisan compared to placebo in women with symptomatic endometriosis. The secondary objective of this study is to evaluate the safety and tolerability of two different doses of vilaprisan in women with symptomatic endometriosis.