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NCT ID: NCT06450301 Recruiting - Asherman's Syndrome Clinical Trials

Senescent Endometrial Cells in Patients With Thin Endometrial Lining

Start date: June 2024
Phase:
Study type: Observational

The goal of this observational study is to determine if thin endometrial lining that is unresponsive to estrogen might be associated with the presence of senescent cells in patients following long-term use of oral contraceptives. The main question it aims to answer is: Are there any senescent cells present in thin endometrial lining? During the luteal phase of the cycle, participants will will undergo: - Gynecologic US to measure the endometrial lining thickness and pattern. - Endometrial biopsy with Pipelle catheter

NCT ID: NCT06448247 Recruiting - Healthy Clinical Trials

A Study of SPY001-001 in Healthy Volunteers

Start date: June 6, 2024
Phase: Phase 1
Study type: Interventional

This is a Phase 1, randomized, double-blind, placebo-controlled, single- and multiple-dose, first in human safety, tolerability, and pharmacokinetic study of SPY001-001 in healthy participants.

NCT ID: NCT06447831 Recruiting - Clinical trials for Interstitial Lung Disease

Assessing Functional Capacity in Directly and Remotely Monitored Home-based Settings: A Protocol for a Multinational Validation Study in Individuals With Chronic Respiratory Diseases

6MST
Start date: February 2, 2024
Phase:
Study type: Observational

The goal of this validation study is to provide further evidence of the metrological properties of the 6-minute stepper test in individuals with chronic obstructive pulmonary disease (COPD) or interstitial lung disease (ILD). The main questions it aims to answer are: 1. Is the 6-minute stepper test valid when compared to the 6-minute walk test and a maximal cardiopulmonary cycling test? 2. Does the 6-minute stepper test give the same results when conducted through direct (i.e., therapist in person) and remote (i.e., videoconferencing) monitoring? 3. Is the 6-minute stepper test safe when conducted at the home of the individual with direct (i.e., therapist in person) or remote (i.e., videoconferencing) monitoring? Participants will: - Conduct the 6-minute stepper test (several trials on separate days) - Conduct the 6-minute walk test (1 trial on 1 day) - Conduct a maximal cardiopulmonary test on a cycle ergometer (1 trial on 1 day) - Participate in a semi-structured interview to provide their feedback with regards to the 6-minute stepper test

NCT ID: NCT06445374 Recruiting - Hypersensitivity Clinical Trials

Effects of Inhaled Epinephrine on Systemic Allergic Reactions During Allergy Testing Immunotherapy or Oral Challenges

Start date: June 2024
Phase: Phase 1
Study type: Interventional

The purpose of this exploratory study is to evaluate the effects of inhaled epinephrine in patients with known or suspected metabisulfite sensitivity who experience a systemic allergic reaction (SAR) while undergoing allergy testing, immunotherapy or oral challenges.

NCT ID: NCT06441877 Recruiting - Sense of Community Clinical Trials

Community Spirit in Residence for the Elderly

437_EsCom
Start date: May 7, 2024
Phase:
Study type: Observational

The objective of our study is to observe and understand factors that emphasizes the creation of a community spirit. Specific objectives: 1. Explore and understand the facilitators and challenges of social participation in a residential context; 2. Explore and understand the facilitators and challenges of creating a sense of community in a residential setting.

NCT ID: NCT06440395 Recruiting - PreDiabetes Clinical Trials

Small Steps for Big Changes - Healthy Cities Implementation Science

HCIS
Start date: June 3, 2024
Phase:
Study type: Observational

Small Steps for Big Changes (SSBC) is a diet and exercise counselling program that significantly reduces the risk of developing Type 2 Diabetes (T2D). In partnership with YMCAs in Canada spanning 8 provinces, the aim of this study is to scale-up program delivery and evaluate the implementation and effectiveness of SSBC. To evaluate implementation, the number of staff trained/patients enrolled, attendance, sessions delivered as planned, delivery costs, and number of sites continuing to deliver the program will be examined. To evaluate program effectiveness, changes in patient health (e.g., T2D status, blood glucose, weight, exercise, diet) will be measured over 2 years following program completion.

NCT ID: NCT06438887 Recruiting - Strength Clinical Trials

Strategic Ingestion of Creatine Supplementation and Resistance Training in Trained Young Adults

Start date: May 15, 2024
Phase: N/A
Study type: Interventional

Creatine supplementation improves measures of muscle accretion and performance compared to placebo during a resistance training program. However, the optimal creatine supplementation protocol for maximizing these improvements is unknown.

NCT ID: NCT06436313 Recruiting - Parkinson Disease Clinical Trials

DBS Virtual Learning Experience

Start date: September 1, 2023
Phase: N/A
Study type: Interventional

The success of Deep Brain Stimulation (DBS) is more correlated to fulfillment of patients' expectations, than merely improvement of motor status1. Therefore, it is of utmost importance to inform the DBS candidates as good as possible to set realistic expectations. Currently, the patient - most of the time accompanied by a family member - is informed about the surgery and its benefits and risks during the outpatient consultation of the neurologist, and later on during the consultation of the neurosurgeon. Written information is provided in the form of a booklet that the patients take home. Due to the large amount of information, not all of it can be captured by the patient. Therefore, we would like to investigate whether an additional online immersive educational session on DBS would better educate the patient. The online session is a 1-hour video call with a small group of DBS candidates and their caregivers, lead by DBS experts, where testimonials of other patients are shown, together with multiple infographics. Two weeks later their will be a second online session summarizing the information and providing the opportunity for Q&A.

NCT ID: NCT06436183 Recruiting - Atopic Dermatitis Clinical Trials

A Study of the Effects of Camoteskimab in Adults With Moderate to Severe Atopic Dermatitis

Start date: May 1, 2024
Phase: Phase 2
Study type: Interventional

This is a Phase 2a, multicenter, randomized, double-blind, placebo-controlled study with an open-label extension to evaluate the efficacy and safety of camoteskimab in adults with moderate to severe AD.

NCT ID: NCT06433453 Recruiting - Ovulation Disorder Clinical Trials

Three Dimensional Ultrasonographic Detection of Human Ovulation

Start date: April 22, 2024
Phase: Phase 4
Study type: Interventional

The research aims to compare diagnosis of ovulation and anovulation in 2D and 3D ultrasonography.