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Coronary Stenosis clinical trials

View clinical trials related to Coronary Stenosis.

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NCT ID: NCT05810610 Not yet recruiting - Coronary Stenosis Clinical Trials

Automatic Anatomical and Functional Classification of Coronary Arteries With Artificial Intelligence.

COROSCAN-IA
Start date: April 2023
Phase:
Study type: Observational

The goal of this Category 3 research involving the human person is to predict the measurement of the post-stenosis flow (FFR) using CTTA coupled with an intelligent predictive analysis system and comparing it with invasive coronary angiography FFR as measurement of reference. The population studied are adult patients,- with no diagnosed coronary status or history of stenting or bypass surgery- with indication for FFR measurement. The main question it aims to answer is: • Can, in a single acquisition, CTTA coupled with AI produce good predictive performance of stenosis and FFR ? If it can it will allow us to avoid the need for invasive FFR. For patients who will be included in the retrospective part: only their data from their medical records will be used. Patients who will be included in the prospective part will additionally complete the EQ5D5L questionnaire before coronary angiography and at the end of the patient's participation (4 months after the CCTA). There is a no comparison group, the predictive FFR from CTTA of a patient will be compared with angiography FFR from the same patient, same vessel.

NCT ID: NCT05804500 Completed - Clinical trials for Coronary Artery Disease

RecoveryPlus Telerehab Platform Pilot Study

Start date: March 27, 2023
Phase: N/A
Study type: Interventional

In this prospective, single-arm study, we will look at the initiation, participation, sustained engagement, and safety of 100 adult subjects (ages 45 years or older) with recent (within the past 60 days) clinician referral to CR who are offered CTR via the RecoveryPlus platform. We want to understand the effectiveness of the RecoveryPlus platform in engaging participants in CR while remaining a safe alternative for the delivery of evidence-based CR content. The primary hypothesis of this study is that the RecoveryPlus CTR platform and patient-facing mobile application provide a safe alternative to traditional in-person CR, and demonstrate a high rate of initiation, participation, and engagement in CR exercise programming than traditional modes of CR delivery, as documented in the literature. Current in-person and non-personalized CR programming lacks RecoveryPlus' convenient remote access, easy-to-use digital tools to support independent, autonomous exercise, and a platform to facilitate engagement and feedback between patients and EPs.

NCT ID: NCT05799092 Recruiting - Clinical trials for Coronary Artery Disease

Invasive Versus Non-invasive Approach in Symptomatic Patient With Non-High Risk Coronary Artery Stenosis

SMART-STEP
Start date: October 2, 2023
Phase: N/A
Study type: Interventional

A pragmatic, prospective, multi-center, open label, randomized controlled, superiority trial. The study will compare clinical outcomes between invasive versus non-invasive approach as next diagnostic step in symptomatic patients with non-high risk obstructive coronary artery disease (CAD) on coronary computed tomography-angiography (CCTA).

NCT ID: NCT05782738 Not yet recruiting - Clinical trials for Coronary Artery Disease

Reverse T-stenting and Minimal Protrusion With External Minicrush for Treatment of Complex Coronary Bifurcation

T-REX
Start date: June 1, 2023
Phase: N/A
Study type: Interventional

The Reverse T-stenting And Minimal Protrusion (Reverse TAP) is an up-front 2-stent technique that treats complex coronary bifurcation. Compared to crush techniques, it does not require crushing of the side branch stent but only minimal protrusion of the side branch stent before main vessel stenting. Nowadays, no studies compare the Reverse-TAP and the External Minicrush in treating complex coronary bifurcation, so eventually, procedural, clinical and safety differences remain unknown.

NCT ID: NCT05757947 Recruiting - Clinical trials for Coronary Artery Disease

Study of the No-touch Saphenous Vein Graft

Start date: December 22, 2022
Phase: N/A
Study type: Interventional

Authors hypothesize that "no-touch" saphenous vein as I graft is superior over conventional "no-touch" saphenous vein as free graft in the incidence of graft patency.

NCT ID: NCT05753085 Not yet recruiting - Clinical trials for Coronary Artery Disease

Multimodality Optical and Ultrasound Intravascular Imaging for Stent Optimization and Atheroma Assessment

MOUSA
Start date: September 1, 2023
Phase: N/A
Study type: Interventional

This investigation is to see if the new Novasight Hybrid imaging catheter can safely and accurately provide two different types of images (IVUS and OCT) of the inside of heart vessels at the same time. The images will be compared against one type of image (IVUS) to see if providing two, improves identification of different types of plaque (fatty substances) and informs better treatment. Atherosclerotic coronary artery disease is the name given to the development of plaques in the heart vessels. The plaques can cause narrowing in the vessels which may cause chest pain. Sometimes, plaques completely block the vessels causing a heart attack. This type of disease is the main cause of death worldwide. Research shows that when the type of plaque causing problems is known, it can help understanding of which narrowing may get worse and cause a heart attack. This information can also help with deciding when and which treatment to provide. Intravascular imaging is a way to assess the inside of the heart arteries. It involves passing a narrow catheter into the heart vessels. The catheter has a probe on its tip that emits light or an ultrasound signal. The signal is reflected by the vessel wall, back into the probe. A computer program interprets the signals and creates images of the inside of the arteries. There are two types of imaging catheters. One uses sound (Intravascular Ultrasound (IVUS)) and one uses light ((OCT) Optical Coherence Tomography) to produce different types of pictures of the vessels and plaques. The images produced by each type do not provide a full picture of the plaques on their own. A new hybrid imaging catheter has been developed which has two probes at the tip, an IVUS probe and an OCT probe and can produce both types of images at the same time. It is likely that having both types of images is better for finding high-risk plaques and should lead to better, more specific treatment. 50 heart attack patients who need an angiogram will have images of their vessels taken during their treatment. Once the imaging is complete the patient will continue with their routine planned care. The information from the images will be used to see how safe and accurate this new hybrid catheter is compared with the separate IVUS and OCT catheters, and also check to see if it is easier to identify plaques that might cause future problems. The study also aims to develop new ways to process and use the images from the hybrid catheter to better treat the plaques that cause the heart attack.

NCT ID: NCT05726604 Recruiting - Breast Cancer Clinical Trials

4D CT Scan Versus 3D CT Scan Concerning Cardiac Dosimetry Assesment for Left Sided Breast Cancers Radiotherapy

RD3D4
Start date: March 2, 2023
Phase: N/A
Study type: Interventional

To establish if the cardiac radiation dose assesment is well aproximated with routine 3D CT scan compared to 4D CT experimental scan with respiratory gating (breath motion monitoring). The study population relates to left side breast cancers female patients that require a radiation therapy treatment.

NCT ID: NCT05713201 Recruiting - Coronary Disease Clinical Trials

Outcomes After PCI of the Aneurysmatic Right Coronary Artery

RIGHT-MARE
Start date: November 1, 2022
Phase:
Study type: Observational

This study aims to evaluate procedural and clinical outcomes of acute coronay syndrome (ACS) patients with aneurysmatic culprit right coronary artery (RCA).

NCT ID: NCT05709652 Recruiting - Clinical trials for Cardiovascular Diseases

Impact of Fast-rotation Coronary CT in Patients Undergoing Aortic Stenosis Workup

FAST-CCT
Start date: February 27, 2024
Phase: N/A
Study type: Interventional

This study aims to evaluate the clinical value of a novel CT gantry supporting a .23 second rotation time and systematically compare it with 0.23 second rotation time, in patients with clinically indicated aortic CTA in the workup of aortic stenosis. Patients will be randomly assigned .23 or .28 sec rotation time CTA. Coronary artery interpretability rates will be determined in both groups.

NCT ID: NCT05667285 Enrolling by invitation - Clinical trials for Native Coronary Artery Stenosis

BIOFLOW-china Post-marketing Study (BIOTRONIK)

Start date: May 26, 2023
Phase:
Study type: Observational

This trial uses prospective, retrospective, observational, non-blinded, multi-center, single-arm, post-marketing hospital data collection and research methods. The goal of this study is to assess the safety of BIOTRONIK Orsiro Sirolimus-Eluting Coronary Stent System in the Chinese patient population after marketing in China.