Influencing Factors of Coronary Heart Disease in Young People

Coronary Heart Disease Clinical Trial

Official title:

To Study the Risk Factors of Youth Coronary Heart Disease From Inflammatory Cytokines，Lifestyle and Familial Inheritance

Clinical Trial Details — Status: Recruiting

Administrative data

• NCT number: NCT05175495
• Other study ID #: Observational
• Status: Recruiting
• Start date: August 1, 2021
• Est. completion date: August 1, 2024

Study information

• Verified date: July 2023
• Source: Affiliated Hospital of Nantong University
• Contact: hzh sheng, Dr.
• Phone: 13515203348
• Email: yjshz[@]ntu.edu.cn
• Is FDA regulated: No
• Study type: Observational

Clinical Trial Summary

The incidence of coronary heart disease in young people is not uncommon and the investigators will explore the factors contributing to this outcome

Description:

Through the multi-center clinical research conducted by several units in Nantong city, the risk factors and aggregation of the incidence of CHD among young people in nantong city were obtained, so as to fill in the blank of domestic multi-center research and reduce the incidence of CHD among young people.The investigators will conduct a long-term follow-up study on the young patients with CHD to screen the factors contributing to the poor prognosis of CHD in young patients.The investigators will fill this gap and intervene early to improve patients' quality of life and prolong their survival

Recruitment information / eligibility

• Status: Recruiting
• Enrollment: 1000
• Est. completion date: August 1, 2024
• Est. primary completion date: August 1, 2024
• Accepts healthy volunteers: No
• Gender: All
• Age group: 18 Years to 45 Years

Eligibility

Inclusion Criteria:

• Diagnosed coronary heart disease

• Confirmed by coronary angiography

• Diagnosed myocardial infarction

• Willing to sign an inform consent

Exclusion Criteria:

• Patients won't sign an inform consent or will not comply with the follow up.

Related Conditions & MeSH terms

• Coronary Artery Disease
• Coronary Disease
• Coronary Heart Disease
• Heart Diseases
• Myocardial Ischemia

Locations

Country	Name	City	State
China	shengHz	Nantong	Jiangsu

Sponsors (2)

Lead Sponsor	Collaborator
Hongzhuan Sheng	Affiliated Hospital of Nantong University

Country where clinical trial is conducted

China, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Whether inflammatory factors are differentially expressed in young patients with coronary heart disease	The Investigators will analyze blood samples from the participants to see if there was a difference in the expression of inflammatory factors with high correlation compared with the control group by ELESA and High-throughput sequencing.	Until April 2024
Primary	The effect of gene activity on youth morbidity	The investigators will use enrichment analysis to screen the target genes and sequence the participants.Whether the target gene was expressed at high levels in the participants.And the investigators will further analyze the target gene	Until April 2024
Primary	Sedentary, high-fat diet, lack of exercise and other unhealthy lifestyle effects on young people	The researchers will retrospectively examine the participants' negative lifestyle habits, such as sedentary behavior, smoking, high-fat diet, and lack of exercise, in combination with their coronary angiography results	Until April 2024