Clinical Trials Logo
  1. Home
  2. Coronary Heart Disease
  3. NCT03529916
  4. Details
NCT03529916 Clinical Trial

Endothelial Cell Gene Networks of CVD

Coronary Heart Disease Clinical Trial

Official title:
Endothelial Cell Gene Networks of CVD

Clinical Trial Details — Status: Withdrawn

Administrative data
NCT number NCT03529916
Other study ID # 12841
Secondary ID
Status Withdrawn
Phase
First received
Last updated
Start date May 21, 2018
Est. completion date September 30, 2021

Study information
Verified date July 2021
Source Tufts University
Contact n/a
Is FDA regulated No
Health authority
Study type Observational

Clinical Trial Summary

The objective of this study is to identify relevant signature gene networks of cardiovascular disease in endothelial cells derived from circulating endothelial progenitor cells of individuals with established cardiovascular disease (CVD).

Description:

The investigators propose to enroll CVD and healthy subjects between 30 and 60 years of age, matched for age, gender, body mass index, and medication (statin and anti-hypertensive) use. Circulating endothelial progenitor cells will be isolated from blood and cultured in vitro to differentiate into endothelial cells.

Recruitment information / eligibility
Status Withdrawn
Enrollment 0
Est. completion date September 30, 2021
Est. primary completion date September 23, 2021
Accepts healthy volunteers Accepts Healthy Volunteers
Gender All
Age group 30 Years to 60 Years
Eligibility Inclusion Criteria for CVD subjects:: • >50% stenosis of one or more coronary arteries Inclusion Criteria for Healthy subjects: • absence of coronary artery stenosis Exclusion Criteria for all subjects: - type 2 diabetes mellitus - chronic kidney disease, - other chronic diseases - dyslipidemia (fasting plasma LDL-C >160 mg/dL and triglyceride levels >150 mg/dL)

Study Design

Related Conditions & MeSH terms

Intervention

Other:
• isolation of endothelial cells precursors in blood
Circulating endothelial precursor cells will be isolated and then cultured in vitro. RNA will be then isolated.

Locations
Country Name City State
United States Tufts Medical Center - Cardiovascular Clinic Boston Massachusetts

Sponsors (2)
Lead Sponsor Collaborator
Tufts University Massachusetts General Hospital

Country where clinical trial is conducted

United States, 

Outcome
Type Measure Description Time frame Safety issue
Primary Gene expression Gene expression [ identify relevant signature gene networks of cardiovascular disease in endothelial cells] 10 weeks
See also
  Status Clinical Trial Phase
Recruiting NCT05196659 - Collaborative Quality Improvement (C-QIP) Study N/A
Completed NCT05088291 - Application of a New X-ray Protective Device in Coronary Interventional Therapy
Completed NCT03076801 - Does Choral Singing Help imprOve Stress in Patients With Ischemic HeaRt Disease? N/A
Completed NCT04584645 - A Digital Flu Intervention for People With Cardiovascular Conditions N/A
Not yet recruiting NCT04995159 - Optimized Antiplatelet Therapy in Patients With CHD After Implantation of NeoVas™ BRS System N/A
Recruiting NCT02967718 - Innovation Research of Differentiation and Treatment Methods Based on CHD Phlegm and Blood Stasis Syndrome N/A
Completed NCT02888652 - Study on the Registration of Coronary Heart Disease Patients Undergoing PCI
Completed NCT02163044 - The Hellenic Postprandial Lipemia Study (HPLS)
Terminated NCT02045134 - Supplementation With Polyphenol-Rich Foods and Atrial Fibrillation After a Cardiac Surgery N/A
Active, not recruiting NCT02244853 - Heart Rate and Cardiovascular Diseases Prognosis in People With Stable Coronary Artery Disease N/A
Completed NCT02753829 - Home-based Cardiovascular Rehabilitation, Maintenance Phase, in Subjects With Coronary Artery Disease N/A
Completed NCT01920009 - Impact of Motivational Interviews Within Pharmacy Care Upon Adherence to Cardiovascular Medicines N/A
Completed NCT02440893 - Understanding the Effect of Metformin on Corus CAD (or ASGES)
Completed NCT01826552 - Comparison of the Angiographic Result of the Orsiro Hybrid Stent With Resolute Integrity Stent Phase 4
Terminated NCT01906957 - Cognition and Exercise Training N/A
Recruiting NCT01689688 - Healing Response to Everolimus-eluting Stent Implantation; Serial Assessment With opticaL Coherence Tomography N/A
Completed NCT01779401 - Clopidogrel Response Evaluation and AnTi-Platelet InterVEntion in High Thrombotic Risk PCI Patients N/A
Recruiting NCT01456364 - Intracoronary Stenting and Antithrombotic Regimen: ADjusting Antiplatelet Treatment in PatienTs Based on Platelet Function Testing Phase 4
Recruiting NCT01462799 - COR-PRIM: Problem-based Learning (PBL) After Coronary Heart Disease (CHD) - Long-term Evaluation in Primary Care of Self-care N/A
Completed NCT01428947 - Does Coronary Angiography Cause Cognitive Dysfunction? N/A