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NCT01805193 Clinical Trial

Myocardial Blood Flow by 15O Water PET

Coronary Heart Disease Clinical Trial

Official title:
Validation of Computed Tomography Myocardial Perfusion Imaging Using Quantification of Myocardial Blood Flow by Positron Emission Tomography With 15O-water

Clinical Trial Details — Status: Completed

Administrative data
NCT number NCT01805193
Other study ID # 12/SS/0078
Secondary ID
Status Completed
Phase
First received
Last updated
Start date December 2012
Est. completion date January 2019

Study information
Verified date February 2019
Source University of Edinburgh
Contact n/a
Is FDA regulated No
Health authority
Study type Observational

Clinical Trial Summary

Coronary heart disease is a very common condition caused by narrowings in the blood vessel supplying the heart. the investigators are studying new tests to diagnose heart disease. In this study the investigators plan to investigate a special scan called a PET/CT (Positron emission tomography/computed tomography) and a new type of CT (Computed tomography) scan to tell us about the flow of blood to the heart muscle.

Description:

Participants will undergo PET/CT with oxygen-15 labelled water and computed tomography myocardial perfusion imaging.

Recruitment information / eligibility
Status Completed
Enrollment 22
Est. completion date January 2019
Est. primary completion date June 2014
Accepts healthy volunteers No
Gender All
Age group 18 Years and older
Eligibility Inclusion Criteria:

- suspected coronary artery disease

Exclusion Criteria:

- inability or unwillingness to undergo CT or PET imaging

- renal failure (serum creatinine >200 um/L or eGFR <30 ml/min)

- hepatic failure

- allergy to iodinated contrast

- pregnancy

- contraindication to adenosine

- inability to give informed consent

- atrial fibrillation with a fast ventricular rate (>70 beats per minute)

Study Design

Related Conditions & MeSH terms

Intervention

Other:
• Computed tomography myocardial perfusion imaging

• Oxygen 15 labelled water positron emission tomography

Locations
Country Name City State
United Kingdom Clinical Research Imaging Centre Edinburgh Scotland

Sponsors (1)
Lead Sponsor Collaborator
University of Edinburgh

Country where clinical trial is conducted

United Kingdom, 

Outcome
Type Measure Description Time frame Safety issue
Primary Myocardial blood flow Myocardial blood flow ( ml/g/min) measured by oxygen-15 water positron emission tomography 1 month
Secondary Fractional flow reserve Fractional flow reserve measured during invasive coronary angiography 1 month
Secondary Myocardial perfusion Myocardial perfusion measured as hypoperfusion on adenosine computed tomography myocardial perfusion imaging 1 month
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