Coronary Heart Disease Clinical Trial
Official title:
Phase 1 Study of Coronary Heart Disease Proteomics Research
The protein composition of HDL is complicated. The investigators have identified 40 distinct
proteins associated with HDL by proteomics technology, and these proteins have been
confirmed to be related to the function of anti-inflammation, anti-oxidation, improvement of
endothelial function, inhibition of thrombosis and so on. And the investigators also found
that the levels of some proteins in HDL changed in patients with coronary heart disease,
compared with the healthy control group.
So, this study is to conduct in the two following aspects: enlarge the sample size to verify
the preliminary results to find new research ideas of pathogenesis and biomarkers for
coronary heart disease; and study the changes of HDL protein composition in patients with
coronary heart disease before and after statins treatment using proteomics technology in
order to find the mechanism of statins pleiotropic effects and indicators for evaluating the
treatment effectiveness.
n/a
Observational Model: Case Control, Time Perspective: Prospective
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