Dynamic Myocardial Perfusion Imaging by 320 Multidetector Computed Tomography

Coronary Heart Disease Clinical Trial

Official title:

Dynamic Myocardial Perfusion Imaging by 320 Multidetector Computed Tomography

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT01368237
• Other study ID #: 210/R/CAR/11
• Status: Completed
• Start date: May 2006
• Est. completion date: January 1, 2017

Study information

• Verified date: October 2014
• Source: University of Edinburgh
• Contact: n/a
• Is FDA regulated: No
• Study type: Observational

Clinical Trial Summary

Recent advances in technology have resulted in the development of scanners that can image the heart blood vessels within 10 to 20 minutes but without the need for admission to hospital or insertion of catheters. Further advances in technology allow the visualisation of both the blood vessels and the supply of blood to the heart muscle. Here we propose to assess the latest and most powerful computed tomography scanner and compare it to magnetic resonance and conventional coronary angiography.

Recruitment information / eligibility

• Status: Completed
• Enrollment: 51
• Est. completion date: January 1, 2017
• Est. primary completion date: June 2014
• Accepts healthy volunteers: No
• Gender: All
• Age group: 18 Years and older

Eligibility

Inclusion Criteria:

• referred for invasive coronary angiography because of suspected coronary heart disease

Exclusion Criteria:

• inability or unwillingness to undergo computed tomography or magnetic resonance imaging

• renal failure (serum creatinine >200 micromol/L or estimated glomerular filtration rate <30 mL/min)

• hepatic failure

• allergy to iodinated contrast or gadolinium

• pregnancy

• contraindication to adenosine infusion

• inability to give informed consent

• inability to perform fractional flow reserve during invasive coronary angiography

Related Conditions & MeSH terms

• Coronary Artery Disease
• Coronary Disease
• Coronary Heart Disease
• Heart Diseases
• Myocardial Ischemia

Intervention

Radiation:
• Computed tomography scan
Computed tomography will be performed using a 320 multidetector computed tomography scanner and may include coronary calcium score, coronary angiography and imaging of myocardial perfusion, function and viability.

Locations

Country	Name	City	State
United Kingdom	Royal Infirmary of Edinburgh	Edinburgh	Scotland

Sponsors (2)

Lead Sponsor	Collaborator
University of Edinburgh	NHS Lothian

Country where clinical trial is conducted

United Kingdom, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Myocardial perfusion defects defined qualitatively by trained observers and quantitatively by computer software	The primary outcome measure is to establish whether 320-multidetector computed tomography can identify myocardial perfusion defects as compared to the gold standards of 3Tesla magnetic resonance imaging and fractional flow reserve measured during invasive coronary angiography.	1 month
Secondary	Identification of regional wall motion abnormalities qualitatively by trained observers	Our secondary outcome measures are to assess the performance of 320-multidetector computed tomography in the detection of regional wall motion abnormalities in comparison to those obtained with 3Tesla cardiac magnetic resonance imaging.	1 month
Secondary	Identification of infarction qualitatively by trained observers	Our secondary outcome measures are to assess the performance of 320-multidetector computed tomography in the detection of infarction in comparison to those obtained with 3Tesla cardiac magnetic resonance imaging.	1 month
Secondary	Identification of regional wall motion abnormalities quantitatively by computer software	Our secondary outcome measures are to assess the performance of 320-multidetector computed tomography in the detection of regional wall motion abnormalities in comparison to those obtained with 3Tesla cardiac magnetic resonance imaging.	1 month
Secondary	Identification of infarction qualitatively by computer software	Our secondary outcome measures are to assess the performance of 320-multidetector computed tomography in the detection of infarction in comparison to those obtained with 3Tesla cardiac magnetic resonance imaging.	1 month