Coronary Heart Disease Clinical Trial
Official title:
Influence of Periodontal Treatment on Systemic Inflammatory Mediators:hsC-reactive Protein, Fibrinogen and White Blood Cells in CHD Patients
Currently the research issue in establishing the role of periodontal disease (PD) in
coronary heart disease (CHD) risk is to define the pathways that lead to cause-effect
relationship between PD and CHD. There is no consensus on definition of a periodontal
disease case or the threshold level that may give clear indication for this relationship.
Periodontal therapy has been used in different studies with the hope that a change in
periodontal disease status may modify the factors associated with CHD risk. Many of these
studies, on role of periodontal therapy in the reduction of CHD associated risk-factors,
were based on small study samples, and very few studies were randomized controlled trials.
So a need for large prospective studies is warranted in literature.----------- A
single-blind parallel-arm randomized controlled clinical trial was designed to observe the
influence of periodontal treatment on serum inflammatory mediators of hsC-reactive protein,
white blood cells and fibrinogen in CHD patients.
Hypothesis: Periodontal therapy in CHD patients, by reducing periodontal inflammation, may
decrease the host systemic inflammatory burden associated with atherogenic processes.
n/a
Allocation: Randomized, Endpoint Classification: Efficacy Study, Intervention Model: Parallel Assignment, Masking: Single Blind (Investigator), Primary Purpose: Treatment
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