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Coronary Disease clinical trials

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NCT ID: NCT02058134 Terminated - Clinical trials for Coronary Artery Disease

The CardioPAT Project: A Randomized Trial

Start date: December 2013
Phase: N/A
Study type: Interventional

The purpose of this study is to determine whether intra- and postoperative use of the cardioPAT® cell saver decreases the need for allogenic red blood cell transfusion in patients, who undergo open heart surgery (with cardiopulmonary bypass) and preoperatively have an increased risk for bleeding.

NCT ID: NCT02045134 Terminated - Clinical trials for Coronary Heart Disease

Supplementation With Polyphenol-Rich Foods and Atrial Fibrillation After a Cardiac Surgery

Polyphemus
Start date: September 2014
Phase: N/A
Study type: Interventional

Post-operative atrial fibrillation (POAF) is a major cause of morbidity and mortality after a cardiac surgery. Both systemic inflammation and oxidative stress play a role in the initiation of POAF after a cardiac surgery. Epidemiological studies show a significant inverse correlation between cardiovascular risk and consumption of polyphenol-rich foods (PRFs), due to antioxidant, vasorelaxant and antithrombotic properties of their polyphenolic components. The main objective of this study is to evaluate the effect of polyphenol-rich food supplementation on post-operative atrial fibrillation (POAF) in patients undergoing an open heart surgery (mainly coronary artery bypass grafts (CABG) and valve replacement or repaired (VR))

NCT ID: NCT02039713 Terminated - Clinical trials for Coronary Artery Disease

DESyne in Routine Clinical Practice

IRIS DESYNE
Start date: July 2014
Phase:
Study type: Observational

The purpose of this study is to evaluate effectiveness and safety of DESyne in Routine Clinical Practice

NCT ID: NCT02005445 Terminated - Clinical trials for Obstructive Sleep Apnea

Obstructive Sleep Apnea Treatment to Improve Cardiac Rehabilitation

Start date: October 1, 2014
Phase: N/A
Study type: Interventional

This is a randomized clinical trial in U.S. Veterans to evaluate the impact of treatment for obstructive sleep apnea (OSA) on the effectiveness of cardiac rehabilitation, including impact on exercise capacity, disability, and quality of life.

NCT ID: NCT01906957 Terminated - Metabolic Syndrome Clinical Trials

Cognition and Exercise Training

COGNEX-2
Start date: September 2013
Phase: N/A
Study type: Interventional

The aim of study is to investigate the impact of two different training modalities (high intensity interval training (HIIT) versus moderate intensity continuous exercise training (MICET) on cognitive performance, cerebral oxygenation, cardiac output and physical fitness in older healthy adults, patients with metabolic syndrome, coronary heart disease and heart failure. The investigators hypothesized that HIIT modality will lead to a larger improvement in physical fitness (i.e. VO2peak), cardiovascular parameters (cardiac output and stroke volume) and cognitive performance at rest and during submaximal exercise. The primary endpoint will be the improvement in cognitive performance.

NCT ID: NCT01892917 Terminated - Clinical trials for Coronary Artery Disease

BIOFLOW-III Hungary Satellite Registry

Start date: September 2012
Phase: N/A
Study type: Observational

This registry is a clinical post-market evaluation of the Orsiro LESS in subjects requiring coronary revascularization with Drug Eluting Stents (DES)

NCT ID: NCT01866904 Terminated - Clinical trials for Stable Coronary Artery Disease (CAD), Myocardial Infarction

Long-Term rIsk, Clinical manaGement and Healthcare Resource Utilization of Stable CAD in Post MI Patients

TIGRIS
Start date: June 19, 2013
Phase:
Study type: Observational

THis study is intended to provide contemporary data on the burden of disease in patients 1 to 3 years post-MI, including a description of patient characteristics, current treatment patterns, rate of major CV events, and healthcare resource utilization in a 'real world' patient population at high atherothrombotic risk.

NCT ID: NCT01863225 Terminated - Clinical trials for Coronary Artery Disease

Characterization of Multi-dose RVX000222 in Combination With Statin Treatment in Dyslipidemia

Start date: May 2013
Phase: Phase 2
Study type: Interventional

This study is designed to characterize the pharmacokinetics of multi-dose RVX000222 and atorvastatin and rosuvastatin when either statin is administered in combination with RVX000222 in subjects with dyslipidemia.

NCT ID: NCT01848106 Terminated - Clinical trials for Coronary Artery Disease

A Study To Determine the Efficacy and Safety of REG1 Compared to Bivalirudin in Patients Undergoing PCI

Regulate
Start date: September 2013
Phase: Phase 3
Study type: Interventional

This study is designed to determine the efficacy of REG1 compared to bivalirudin in preventing periprocedural ischemic complications and major bleeding in patients undergoing PCI as a treatment for CAD. Bivalirudin has been studied in patients undergoing PCI in both ACS (NSTEMI and unstable angina [UA]) and elective PCI. In comparison to UFH, bivalirudin has shown similar rates of ischemic events while demonstrating a significant reduction in bleeding and an improved net clinical benefit. Evidence from previous studies indicates that pegnivacogin represents an extremely potent, chemically unique anticoagulant that can be reversed by anivamersen across multiple populations (refer to Section 1.2.2). The question that still remains is whether Factor IX (FIX) inhibition by pegnivacogin can result in fewer ischemic events than a previously studied agent while active control with anivamersen can preserve the benefit of reduced bleeding. The purpose of this study is to evaluate REG1 in an adequately powered definitive study with an open-label, multi-center, active-controlled, randomized design to answer that question.

NCT ID: NCT01823809 Terminated - Clinical trials for Coronary Artery Disease

Non-invasive and Invasive Assessment of Coronary Artery Disease

COMFORT
Start date: November 2011
Phase: N/A
Study type: Interventional

The purpose of the study is to assess the diagnostic accuracy of a combined use of non-invasive coronary angiography with multi-slice computed tomography (MSCT) and stress cardiac magnetic resonance (CMR) imaging in patients with obstructive lesions on MSCT and with low to intermediate pre-test likelihood of coronary artery disease (CAD) as compared to invasive coronary angiography (CAG) and Fractional Flow Reserve (FFR) measurements.