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NCT05188443 Clinical Trial

Radiological Imaging in Patients Tested for COVID-19

Coronary Artery Disease Clinical Trial

Official title:
Radiological Imaging in Patients Tested for COVID-19

Clinical Trial Details — Status: Active, not recruiting

Administrative data
NCT number NCT05188443
Other study ID # 20/WA/0184
Secondary ID
Status Active, not recruiting
Phase
First received
Last updated
Start date August 1, 2020
Est. completion date July 1, 2024

Study information
Verified date June 2023
Source University of Edinburgh
Contact n/a
Is FDA regulated No
Health authority
Study type Observational

Clinical Trial Summary

It has become apparent that patients with co-morbidities have an increased risk of mortality from coronarvirus disease 2019 (COVID-19). However, the impact of subclinical respiratory and cardiovascular disease on the outcome of patients with COVID-19 is currently unknown. This observational study will assess the impact of incidental cardiovascular calcification on radiological imaging on the outcomes of patients with COVD-19.

Description:

It has become apparent that patients with co-morbidities have an increased risk of mortality from coronarvirus disease 2019 (COVID-19). However, the impact of subclinical respiratory and cardiovascular disease on the outcome of patients with COVID-19 is currently unknown. Subclinical respiratory and cardiovascular disease can be identified on radiological imaging. For example, calcification in blood vessels can identify cardiovascular disease, intra-thoracic and intra-abdominal fat is associated with coronary artery disease, and lung diseases can be identified on CT and x-ray. The impact these radiological features on the outcomes of patients with COVID-19 is currently unknown. This study aims to assess the radiological imaging of patients tested for COVID-19 in order to identify the presence of co-existing respiratory and cardiovascular disease and assess their impact on clinical outcomes. All patients tested for COVID-19 with current or previous (last 3 years) radiological imaging will be included in this study. Radiological images will be de-identified and assessed for the presence of cardiovascular calcification. Information on COVID-19 tests and clinical factors will be obtained from routinely collected data. Additional clinical information will be obtained from electronic health records as required.

Recruitment information / eligibility
Status Active, not recruiting
Enrollment 1000
Est. completion date July 1, 2024
Est. primary completion date July 1, 2023
Accepts healthy volunteers No
Gender All
Age group 18 Years and older
Eligibility Inclusion Criteria: - One or more positive RT-PCR test for COVID-19. - One or more CT or chest x-ray available performed within the last 3 years Exclusion Criteria: - No available radiological imaging within the last 3 years

Study Design

Related Conditions & MeSH terms

Locations
Country Name City State
United Kingdom University of Edinburgh Edinburgh Scotland

Sponsors (1)
Lead Sponsor Collaborator
University of Edinburgh

Country where clinical trial is conducted

United Kingdom, 

Outcome
Type Measure Description Time frame Safety issue
Other Myocardial infarction Myocardial infarction 1 month
Primary All cause mortality All cause mortality 1 month
Secondary Cardiovascular mortality Cardiovascular mortality 1 month
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