Coronary Artery Disease Clinical Trial
Official title:
Evaluation of the Effect of Espresso on Platelet Aggregability in Patients With Coronary Artery Disease
Discovered thousands of years ago, coffee is among the most consumed beverages in the world. The relationship between coffee and cardiovascular risk, more specifically coronary artery disease, is controversial. Platelet aggregation and its relationship with coffee is also controversial. The investigators propose this study to evaluate the relationship between coffee and platelet aggregability in patients with coronary artery disease.
30 patients with coronary artery disease (proven by previous coronary angiography) will be selected at the Heart Institute (InCor USP) for the study. Patients will be instructed to abstain from caffeinated beverages during 22 days. After this period, one group will consume caffeinated coffee during 28 days, followed by decaffeinated coffee during more 28 days and another group will start with decaffeinated coffee followed by caffeinated. All participants will receive "Nespresso" coffee maker "Essenza" model. The coffee "Nespresso blend voluto" will be provided (caffeinated and decaffeinated). The patients will have to take four cups of espresso per day (three cups a day for patients aged 65 and over). The investigators will evaluate platelet aggregation by Multiplate® (ASPI, ADP and arachidonic acid) and by optical aggregometry (ADP and arachidonic acid). ;
| NCT number | NCT04827251 |
| Study type | Interventional |
| Source | University of Sao Paulo |
| Contact | Jose Carlos Nicolau, PhD |
| Phone | 55112661-5850 |
| [email protected] | |
| Status | Recruiting |
| Phase | N/A |
| Start date | March 18, 2019 |
| Completion date | December 10, 2021 |
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