Coronary Artery Disease Clinical Trial
— GUT-ACSOfficial title:
The Role of Gut Leakage Markers and Microbiota Signature in Coronary Artery Disease.
Define a signature of gut microbiota composition and related metabolites in patients with ST-elevation myocardial infarction, non ST-elevation myocardial infarction and chronic coronary disease (CAD).
Status | Recruiting |
Enrollment | 200 |
Est. completion date | December 31, 2023 |
Est. primary completion date | December 31, 2021 |
Accepts healthy volunteers | No |
Gender | All |
Age group | 18 Years to 75 Years |
Eligibility | Inclusion Criteria: - Coronary heart disease verified by coronary angiography Exclusion Criteria: - Current infection requiring intravenous antibiotics - Inflammatory bowel disease - Renal failure with creatinine > 200µmol/L - Hepatic impairment - Pregnancy - Previous bariatric surgery - Colostomy - Active malignant disease |
Country | Name | City | State |
---|---|---|---|
Norway | Department of Cardiology, Oslo University Hospital Ullevål | Oslo |
Lead Sponsor | Collaborator |
---|---|
Oslo University Hospital | The Research Council of Norway |
Norway,
Type | Measure | Description | Time frame | Safety issue |
---|---|---|---|---|
Primary | Microbiota alpha diversity in myocardial infarction measured as Chao1 Index. | fecal-sample. 16srRNA (Miseq) will be used for sequencing. | Within 7 days from inclusion. | |
Primary | Microbiota alpha diversity in myocardial infarction measured as Chao1 Index | fecal-sample. 16srRNA (Miseq) will be used for sequencing. | At 3 months follow-up. | |
Primary | Lipopolysaccharide binding protein (LBP) in myocardial infarction | Blood sample. Analyses will be performed with ELISA. | At inclusion | |
Primary | Lipopolysaccharide binding protein (LBP) in myocardial infarction | Blood sample. Analyses will be performed with ELISA. | Change from inclusion to 3 months follow-up. | |
Primary | Soluble cluster of difference-14 in myocardial infarction | Blood sample. Analyses will be performed with ELISA. | At inclusion | |
Primary | Soluble cluster of difference-14 in myocardial infarction | Blood sample. Analyses will be performed with ELISA. | Change from inclusion to 3 months follow-up. | |
Primary | Intestinal fatty acid binding protein-1 in myocardial infarction | Blood sample. Analyses will be performed with ELISA. | At inclusion | |
Primary | Intestinal fatty acid binding protein-1 in myocardial infarction | Blood sample. Analyses will be performed with ELISA. | Change from inclusion to 3 months follow-up. |
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