Coronary Artery Disease Clinical Trial
Official title:
Interplay of miRNA-146a and miRNA-126 in Chronic Periodontitis Patients With Coronary Artery Disease
Verified date | October 2020 |
Source | Meenakshi Ammal Dental College and Hospital |
Contact | n/a |
Is FDA regulated | No |
Health authority | |
Study type | Observational |
The role of micro-RNAs in chronic periodontitis associated with CAD is still in an incipient stage needs to be explored further. The investigators attempt to quantify and compare the levels of micro-RNA 146a and micro-RNA 126 in subgingival as well as coronary plaque samples obtained from patients diagnosed with chronic periodontitis with and without coronary artery disease.
Status | Completed |
Enrollment | 75 |
Est. completion date | December 31, 2019 |
Est. primary completion date | December 1, 2019 |
Accepts healthy volunteers | No |
Gender | Male |
Age group | 30 Years to 70 Years |
Eligibility |
Inclusion criteria: - Patients volunteering for the investigation. - Patients between the age group of 30-70 years - Presence of = 15 natural teeth. Exclusion criteria: - Patients associated with systemic diseases such as lung disorders, renal disease, liver disease, type I, type II-diabetes mellitus, HIV infection, rheumatoid arthritis, allergy or any malignancy. - Under treatment with antibiotics, immunosuppressive drugs such as corticosteroids, within 6 months. - Pregnant women and female patients were excluded because of the altered oral flora due to hormonal changes - Smoking and other tobacco usage habits - Patients who underwent periodontal treatment within 6 months. |
Country | Name | City | State |
---|---|---|---|
India | Meenakshi Ammal Dental college | Chennai | Tamil Nadu |
Lead Sponsor | Collaborator |
---|---|
Meenakshi Ammal Dental College and Hospital |
India,
Type | Measure | Description | Time frame | Safety issue |
---|---|---|---|---|
Primary | micro-RNA 146-a expression in Chronic periodontitis patients with and without coronary heart disease. | microRNA 146-a expression was present in the chronic periodontitis subjects with coronary heart disease | 10 months | |
Primary | Levels of micro-RNA 126 in chronic periodontitis patients with and without coronary heart disease | microRNA 126 expression was present in chronic periodontitis subjects with coronary heart disease | 10 months |
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