Interplay of miRNA-146a & miRNA-126 in Chronic Periodontitis Patients With

Status Completed

Clinical Trial Summary

Clinical Trial Description

The role of micro-RNAs in chronic periodontitis associated with CAD is still in an incipient stage needs to be explored further. The investigators attempt to quantify and compare the levels of micro-RNA 146a and micro-RNA 126 in subgingival as well as coronary plaque samples obtained from patients diagnosed with chronic periodontitis with and without coronary artery disease.

Seventy-five participants were selected and grouped into 3 categories; 25 patients diagnosed with chronic periodontitis and coronary artery disease: CP + CAD group; 25 patients diagnosed with chronic periodontitis alone: CP group; and 25 systemically and periodontally healthy controls (HP). Demographic variables, periodontal parameters, cardiac parameters, blood pressure were obtained. miRNA-146a and miRNA126 levels were assessed in subgingival plaque (SP) samples from all the three groups. Within CP+CAD group, SP samples of CP+CADa were compared with coronary plaques samples (CP) of CP+CADb while the patient underwent CABG. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details

NCT number	NCT04583085
Study type	Observational
Source	Meenakshi Ammal Dental College and Hospital
Contact
Status	Completed
Phase
Start date	November 1, 2018
Completion date	December 31, 2019

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Interplay of miRNA-146a and miRNA-126 in Chronic Periodontitis Patients With Coronary Artery Disease

Clinical Trial Summary

Clinical Trial Description

Study Design

Related Conditions & MeSH terms