Coronary Artery Disease Clinical Trial
— SCOOPOfficial title:
Surgical Coronary Revascularization Outcomes After Oral Anticoagulation or Antiplatelet Strategies
The primary purpose of this study is to evaluate whether treatment with oral anticoagulation or oral anticoagulation and aspirin is better than aspirin alone in cardiovascular outcomes and saphenous graft patency in patients submitted to coronary artery bypass graft.
Status | Not yet recruiting |
Enrollment | 100 |
Est. completion date | December 31, 2020 |
Est. primary completion date | December 31, 2019 |
Accepts healthy volunteers | No |
Gender | All |
Age group | 18 Years and older |
Eligibility |
Inclusion Criteria: - Patients referred to coronary artery bypass graft and at least one saphenous vein graft Exclusion Criteria: - Need for dual antiplatelet therapy, other non-aspirin antiplatelet therapy or oral anticoagulant therapy - Stroke within 1 month or any history of hemorrhagic or lacunar stroke - Estimated glomerular filtration rate (eGFR)<15 mL/min |
Country | Name | City | State |
---|---|---|---|
Portugal | Centro Hospitalar e Universitário de Coimbra | Coimbra |
Lead Sponsor | Collaborator |
---|---|
Centro Hospitalar e Universitário de Coimbra, E.P.E. |
Portugal,
Type | Measure | Description | Time frame | Safety issue |
---|---|---|---|---|
Primary | MACE | Time from randomization to the first occurrence of either myocardial infarction, stroke, or cardiovascular death | 5 years | |
Primary | Graft Patency | Time from randomization to the first occurence of saphenous graft oclusion | 5 years | |
Primary | Major Bleeding | Time from randomization to the first occurrence of major bleeding (modified International Society on Thrombosis and Haemostasis) | 5 years | |
Secondary | MACE, cardiovascular death | Time from randomization to first occurrence of either coronary heart disease death, myocardial infarction, ischemic stroke, acute limb ischemia | 5 years | |
Secondary | All-cause mortality | Time from randomization to first occurrence of all-cause mortality | 5 years |
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