Coronary Artery Disease Clinical Trial
— ACROSSOfficial title:
Assessment of Change in Atherosclerotic Plaque by Serial CCTA
Assessment of Change in AtheROSclerotic Plaque by Serial CCTA (ACROSS) is designed as a prospective observational study which aim is to demonstrate the effect of statins on coronary atherosclerosis, assessed by quantitative analysis of CCTA.
Status | Recruiting |
Enrollment | 400 |
Est. completion date | October 31, 2020 |
Est. primary completion date | February 28, 2020 |
Accepts healthy volunteers | No |
Gender | All |
Age group | 19 Years and older |
Eligibility |
Inclusion Criteria: - Patients who underwent clinically indicated CCTA (index CCTA) - Mild to moderate stenosis (25-69%) on CCTA - =1 clinical risk factors (Smoking, HTN, HDL<40, Premature FHx, M =45, F =55) for CAD Exclusion Criteria: - Acute coronary syndrome (unstable angina or MI) - Positive (not equivocal) stress test - Contraindications to statin |
Country | Name | City | State |
---|---|---|---|
Korea, Republic of | Severance Cardiovascular Hospital, Yonsei University College of Medicine | Seoul |
Lead Sponsor | Collaborator |
---|---|
Yonsei University | Chong Kun Dang Pharmaceutical Corp. |
Korea, Republic of,
Type | Measure | Description | Time frame | Safety issue |
---|---|---|---|---|
Primary | Difference in percent change of total atheroma volume assessed by CCTA between statin-taking and statin-naïve group | Patients indicated with statin therapy according to current guideline will receive atorvastatin. | 24 months | |
Secondary | Change of total atheroma volume at 24 months compared with baseline total atheroma volume | total atheroma volume assessed by CCTA | 24 months |
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