Coronary Artery Disease Clinical Trial
Official title:
Myocardial Mass Determination of the Different Coronary Territories by FFRct and Invasive Measurement of Absolute Coronary Blood Flow. A Clinical Registry
The background for performing the present study is to compare the mass calculations by CT scanning and by invasive absolute blood flow measurements and thereby corroborating both methods.
Although knowledge about the myocardial mass (in grams) of the different territories
belonging to the major coronary arteries, is of clinical importance to estimate risk of
coronary interventions (PCI, CABG) and to determine area of necrosis after myocardial
infarction, no invasive methodology has been available so far for reliable assessment of
mass.
Especially in the setting of percutaneous coronary intervention (PCI), it would be valuable
to have information about the absolute and relative myocardial mass distal to the location
where the intervention is planned. Such information is valuable for risk estimation and can
also be helpful in multivessel disease to determine the most adequate way of
revascularization.
Both MRI and CT scanning have claimed to be able to estimate myocardial mass non-invasively,
but by the lack of any gold standard, none of these methods could be validated in vivo so
far.
A relatively new development in CT technology is the calculation of fractional flow reserve
(FFR) by CT scanning, according to a sophisticated algorithm developed by Heartflow Inc. One
of the baseline assumptions in that algorithm is that myocardial mass is proportional to
resting blood flow, which seems a plausible assumption from a rational physiological point of
view.
More recently, invasive calculation of absolute blood flow has become possible as well as
resistance measurement of the (microcirculation of the) myocardium.
Using that invasive technology (explained in the appendix to this protocol), it can be
assumed that measuring absolute maximum blood flow in a coronary artery as well as fractional
flow reserve for different territories or for different spots within one major coronary
artery, provides a basis for relative mass calculation. The background for performing the
present study is to compare these mass calculations by CT scanning and by invasive
measurements, thereby corroborating both methods.
;
| Status | Clinical Trial | Phase | |
|---|---|---|---|
| Recruiting |
NCT06030596 -
SPECT Myocardial Blood Flow Quantification for Diagnosis of Ischemic Heart Disease Determined by Fraction Flow Reserve
|
||
| Completed |
NCT04080700 -
Korean Prospective Registry for Evaluating the Safety and Efficacy of Distal Radial Approach (KODRA)
|
||
| Recruiting |
NCT03810599 -
Patient-reported Outcomes in the Bergen Early Cardiac Rehabilitation Study
|
N/A | |
| Recruiting |
NCT06002932 -
Comparison of PROVISIONal 1-stent Strategy With DEB Versus Planned 2-stent Strategy in Coronary Bifurcation Lesions.
|
N/A | |
| Not yet recruiting |
NCT06032572 -
Evaluation of the Safety and Effectiveness of the VRS100 System in PCI (ESSENCE)
|
N/A | |
| Recruiting |
NCT04242134 -
Drug-coating Balloon Angioplasties for True Coronary Bifurcation Lesions
|
N/A | |
| Recruiting |
NCT05308719 -
Nasal Oxygen Therapy After Cardiac Surgery
|
N/A | |
| Completed |
NCT04556994 -
Phase 1 Cardiac Rehabilitation With and Without Lower Limb Paddling Effects in Post CABG Patients.
|
N/A | |
| Recruiting |
NCT05846893 -
Drug-Coated Balloon vs. Drug-Eluting Stent for Clinical Outcomes in Patients With Large Coronary Artery Disease
|
N/A | |
| Recruiting |
NCT06027788 -
CTSN Embolic Protection Trial
|
N/A | |
| Recruiting |
NCT05023629 -
STunning After Balloon Occlusion
|
N/A | |
| Completed |
NCT04941560 -
Assessing the Association Between Multi-dimension Facial Characteristics and Coronary Artery Diseases
|
||
| Completed |
NCT04006288 -
Switching From DAPT to Dual Pathway Inhibition With Low-dose Rivaroxaban in Adjunct to Aspirin in Patients With Coronary Artery Disease
|
Phase 4 | |
| Completed |
NCT01860274 -
Meshed Vein Graft Patency Trial - VEST
|
N/A | |
| Recruiting |
NCT06174090 -
The Effect of Video Education on Pain, Anxiety and Knowledge Levels of Coronary Bypass Graft Surgery Patients
|
N/A | |
| Completed |
NCT03968809 -
Role of Cardioflux in Predicting Coronary Artery Disease (CAD) Outcomes
|
||
| Terminated |
NCT03959072 -
Cardiac Cath Lab Staff Radiation Exposure
|
||
| Recruiting |
NCT05065073 -
Iso-Osmolar vs. Low-Osmolar Contrast Agents for Optical Coherence Tomography
|
Phase 4 | |
| Recruiting |
NCT04566497 -
Assessment of Adverse Outcome in Asymptomatic Patients With Prior Coronary Revascularization Who Have a Systematic Stress Testing Strategy Or a Non-testing Strategy During Long-term Follow-up.
|
N/A | |
| Completed |
NCT05096442 -
Compare the Safety and Efficacy of Genoss® DCB and SeQuent® Please NEO in Korean Patients With Coronary De Novo Lesions
|
N/A |