Coronary Artery Disease Clinical Trial
Official title:
Relationship Between Coronary Plaque Morphology of Left Anterior Descending Artery and Long Term Clinical Outcome: the CLIMA Study
The multicenter observational CLIMA registry has been conceived to explore correlation between OCT morphology of atherosclerotic plaques located in the left anterior descending artery with mid and long term clinical outcome.
Acute myocardial infarction (MI) is commonly caused by plaque ulceration and subsequent local
thrombosis. Plaques that tend to rupture are typically characterized by a large superficial
lipid pool, delimited by a thin fibrous cap and often exhibit local signs of inflammation.
Such atherosclerotic lesions are commonly described as vulnerable plaques (1-4).
Identification of these plaque features with imaging modalities is potentially a valid
approach to identify patients at increased risk of M (5). Optical coherence tomography is
capable of visualizing superficial plaque components at a high resolution (in the range of
10-15 microns) and can depict all the features of plaque vulnerability or thrombogenicity
(6,7).
The aim of the study is to relate presence of multiple OCT criteria of plaque vulnerability
with following clinical events in a subset of coronary lesions. For this purpose all plaques
in the proximal-mid portion of the left anterior descending artery will be evaluated with
FD-OCT assessing the following criteria:
- minimum lumen area (MLA) <3.5 mm2:
- fibrous cap minimum thickness <75 µm:
- lipid arc extension >180°;
- presence of macrophages;
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