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NCT02862522 Clinical Trial

Uric Acid Levels and Endothelial Functions

Coronary Artery Disease Clinical Trial

Official title:
Clinical Follow-up of Patients With Assessment of Endothelial Dysfunction/Coronary Spasm

Clinical Trial Details — Status: Completed

Administrative data
NCT number NCT02862522
Other study ID # 05-004191
Secondary ID R01HL092954R01AG
Status Completed
Phase N/A
First received August 8, 2016
Last updated August 8, 2016
Start date January 1992
Est. completion date February 2016

Study information
Verified date August 2016
Source Mayo Clinic
Contact n/a
Is FDA regulated No
Health authority United States: Institutional Review Board
Study type Observational

Clinical Trial Summary

Uric acid is a risk factor for coronary artery disease (CED) in postmenopausal women but the association with inflammation and coronary microvascular endothelial dysfunction is not well-defined. The aim of this study was to determine the relationship of serum uric acid, inflammatory markers and CED.

Recruitment information / eligibility
Status Completed
Enrollment 229
Est. completion date February 2016
Est. primary completion date February 2016
Accepts healthy volunteers No
Gender Female
Age group 50 Years and older
Eligibility Inclusion Criteria:

- Referred to Mayo Clinic for cardiac catheterization

- Postmenopausal

Exclusion Criteria:

- History of percutaneous coronary intervention

- Coronary artery bypass graft surgery

- Unstable angina pectoris

- Valvular heart disease

- Peripheral vascular disease

- Known congestive heart failure

Study Design

Observational Model: Cohort, Time Perspective: Prospective

Related Conditions & MeSH terms

Intervention

Other:
• Questionnaire of overall health
The standardized questionnaire was used to assess occurrence of major adverse cardiovascular events including stroke, re-hospitalization, myocardial infarction or death. Responses were verified by medical record review conducted by an investigator blinded to the results of the standardized questionnaire.

Locations
Country Name City State
United States Mayo Clinic Rochester Minnesota

Sponsors (3)
Lead Sponsor Collaborator
Mayo Clinic National Heart, Lung, and Blood Institute (NHLBI), National Institute on Aging (NIA)

Country where clinical trial is conducted

United States, 

Outcome
Type Measure Description Time frame Safety issue
Primary Serum Uric Acid Level Baseline No
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