Effect of Garlic Tablet Some Indicators Related to Atherosclerosis

Coronary Artery Disease Clinical Trial

Official title:

Effect of Garlic Tablet on Carotid Intima Media Thickness and Flow-mediated Dilation in Patients Undergoing Angioplasty

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT01948453
• Other study ID #: 513
• Status: Completed
• Phase: N/A
• First received: September 14, 2013
• Last updated: May 27, 2015
• Start date: August 2013
• Est. completion date: September 2014

Study information

• Verified date: September 2013
• Source: Shahid Beheshti University
• Contact: n/a
• Is FDA regulated: No
• Health authority: Iran: Ministry of Health
• Study type: Interventional

Clinical Trial Summary

The purpose of this study is to determine whether garlic in adjunct to conventional medical treatment is effective in improving carotid intima media thickness (CIMT), Flow mediated dilation (FMD) and plasma lipid profile or c-reactive protein of coronary artery disease (CAD) patients.

Recruitment information / eligibility

• Status: Completed
• Enrollment: 56
• Est. completion date: September 2014
• Est. primary completion date: September 2014
• Accepts healthy volunteers: No
• Gender: Both
• Age group: 25 Years to 75 Years

Eligibility

Inclusion Criteria:

• angiography confirmed coronary artery disease

• lack of consistent use of the garlic in the last month

Exclusion Criteria:

Change in type of medication during study

Study Design

Allocation: Randomized, Endpoint Classification: Efficacy Study, Intervention Model: Parallel Assignment, Masking: Double Blind (Subject, Caregiver, Investigator, Outcomes Assessor), Primary Purpose: Supportive Care

Related Conditions & MeSH terms

• Coronary Artery Disease
• Coronary Disease
• Myocardial Ischemia

Intervention

Dietary Supplement:
• Garlic
Garlic tablet in adjunct to medical treatment

Locations

Country	Name	City	State
Iran, Islamic Republic of	Rajaei Cardiovascular, Medical & Research Center	Tehran

Sponsors (1)

Lead Sponsor	Collaborator
Shahid Beheshti University

Country where clinical trial is conducted

Iran, Islamic Republic of, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Other	plasma levels of Alanine Aminotransferase, Aspartate Aminotransferase, creatinine, lipid profile, C-Reactive Protein	Change from baseline in plasma levels at 12 weeks	12 weeks	Yes
Primary	Carotid Intima Media Thickness	Change from baseline and compared to placebo group in Carotid Intima Media Thickness at 12 weeks	12 weeks	No
Secondary	Flow-mediated dilatation	Change from baseline and compared to placebo group in Flow-mediated dilatation at 12 weeks	12 weeks	No