Coronary Artery Disease Clinical Trial
Official title:
Validation of an Intracycle CT Motion CORrection Algorithm for Diagnostic AccuracY: A Prospective Multicenter Study
To demonstrate the incremental utility of SSF for individuals undergoing CCTA, with expected improvements in image quality and diagnostic accuracy.
Hypothesis: Coronary CT angiography (CCTA) employing a novel intracycle motion compensation
algorithm (SnapShot Freeze [SSF]) will be superior to CCTA without an intracycle motion
compensation algorithm ("conventional" CCTA) for diagnostic accuracy and image quality.
Scientific Basis: Preliminary study (Leipsic, Min, Journal of Cardiovascular Computed
Tomography [in press]) of coronary CT angiograms in individuals undergoing pre-procedural
assessment for transcatheter aortic valve replacement (n=36) demonstrate improved image
quality of CCTA using SSF compared to CCTA not using SSF. Importantly, individuals in this
study did not receive heart rate slowing agents (e.g., beta blockers), and diagnostic image
quality was substantially improved. While not statistically powered on a per-patient basis,
per-segment diagnostic accuracy of CCTA using SSF was superior to conventional CCTA. These
results are complementary to those derived from internal testing at GE Healthcare wherein
phantom work has demonstrated improved diagnostic performance using SSF compared to
conventional image acquisitions.
Long-term Goal/Purpose: To demonstrate the incremental utility of SSF for individuals
undergoing CCTA, with expected improvements in image quality and diagnostic accuracy. If the
aims of this study are achieved, the use of SSF for effective temporal resolution
improvement may obviate (or reduce) the need for CT hardware for improved temporal
resolution.
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Observational Model: Cohort, Time Perspective: Prospective
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