Effect of Ticagrelor vs. Dipyridamole on Adenosine Uptake

Status Completed

Clinical Trial Summary

The investigators are trying to determine if a single dose of Ticagrelor will increase delivery of intraarterially-infused adenosine into the forearm interstitium, consistent with adenosine reuptake blockade.

Clinical Trial Description

The investigators will compare adenosine interstitial levels using a parallel design study with three groups of subjects. Forearm interstitial adenosine levels will be measured at baseline and after intrabrachial infusion of adenosine at two doses. Subjects will then randomly receive Ticagrelor 180 mg, Dipyridamole 200 mg, or placebo. Two hours later the investigators will repeat the dialysate collections at baseline and after adenosine infusions. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details

NCT number	NCT01690884
Study type	Interventional
Source	Vanderbilt University Medical Center
Contact
Status	Completed
Phase	Phase 1
Start date	August 2012
Completion date	January 2017

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