Coronary Artery Disease Clinical Trial
Official title:
The Effect Of Antiplatelets Therapy, Tirafiban, Prasugrel, And Aspirin On Saphenous Vein Coronary Artery Bypass Graft Patency
This protocol is designed to evaluate the effect of antiplatelets (Tirafiban and Prasugrel) on the incidence of early and intermediate graft patency after CABG.
Coronary artery bypass graft (CABG) surgery is a commonly used revascularization strategy in
patients with severe coronary artery disease. Saphenous vein grafts (SVGs) are the most
frequently used conduits for this procedure. Unlike arterial grafts, SVGs are particularly
susceptible to occlusive thrombosis during the first post-operative year, which exposes
patients to increased risks of death, myocardial infarction, and repeat revascularization.
This study is designed to evaluate the effect of antiplatelets (Tirafiban and Prasugrel) on
the incidence of early and intermediate graft patency after CABG. Patients will undergo
planned cardiac Computed tomographic angiography (CTA) predischarge (at 1 week) and
CTA/coronary angiography (CAG) at 6 months to 1 year follow-up. CTA at baseline
(predischarge) and follow-up CTA/CAG at 6-12 months after CABG will be used to evaluate
graft patency.
;
Allocation: Randomized, Endpoint Classification: Safety/Efficacy Study, Intervention Model: Parallel Assignment, Masking: Open Label, Primary Purpose: Treatment
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