Coronary Artery Disease Clinical Trial
Official title:
TWice overnIght High-dose ranoLazIne Pretreatment for preventinG Myocardial iscHemic Damage in Patients With Stable Angina Undergoing percuTaneous Coronary Intervention
It has previously been shown that pretreatment with ranolazine 1,000 mg twice daily for 7 days can significantly reduce procedural myocardial injury in elective percutaneous coronary intervention (PCI). The investigators tested the hypothesis that twice overnight high-dose ranolazine loading before PCI can reduce the peri-procedural myocardial ischemic damage similarly to long-term pre-treatment with standard doses.
Background
Ranolazine is a novel antianginal drug that reduces intracellular sodium and calcium
accumulation during ischemia thus limiting ischemic injury.
It has previously been shown that pretreatment with ranolazine 1,000 mg twice daily for 7
days can significantly reduce procedural myocardial injury in elective percutaneous coronary
intervention.
It remains unknown, however, which of these two therapeutic approaches is more effective
after PCI.
Purpose
The primary objective of this study is to test the hypothesis that twice overnight high-dose
ranolazine loading before PCI can reduce the peri-procedural myocardial ischemic damage
similarly to long-term pre-treatment with standard doses.
;
Allocation: Randomized, Endpoint Classification: Efficacy Study, Intervention Model: Parallel Assignment, Masking: Double Blind (Subject, Caregiver, Investigator), Primary Purpose: Treatment
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