Coronary Artery Disease Clinical Trial
Official title:
DNA Double-strand Breaks Following Myocardial Scintigraphy
Ionizing radiation has a number of harmful effects in humans. The most important among these
is the induction of cancer. It is assumed that damage to DNA in the nucleus of a single cell
can induce cancer. Among the different types of lesions inducted, DNA double-strand breaks
(DSBs) are considered to be the most relevant effects that can initiate carcinogenesis.
The investigators are already conducting several other studies to prospectively compare the
inducted DSBs by coronary CT-angiography and conventional coronary angiography. Extending
these examinations to investigate the induced DSBs by myocardial scintigraphy allows a
comparison of all three relevant imaging methods of the heart that incorporate ionizing
radiation.
To evaluate this, the investigators are planning to examine patients who are scheduled for a
clinically indicated myocardial scintigraphy. These examinations are routinely done by the
Department of Nuclear Medicine in either a 1-day or a 2-day protocol according to the
diagnostic reference values of the Federal Department for Radiological Protection. Blood
samples will be taken from these patients at predefined time steps before and after the
examination and DNA double-strand breaks will be determined from these blood samples
specifically considering the applied activity of the tracer and the exposition kinetics.
n/a
Observational Model: Cohort, Time Perspective: Prospective
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