Adiponectin and Circulating Progenitor Cells (CPC) Function

Coronary Artery Disease Clinical Trial

Official title:

Adiponectin Promotes the Migration of Circulating Progenitor Cells Through p38-mediated Induction of the CXCR4 Receptor

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT01272674
• Other study ID #: adipo2008
• Status: Completed
• Phase: Phase 1
• First received: January 7, 2011
• Last updated: June 1, 2015
• Start date: January 2011
• Est. completion date: March 2011

Study information

• Verified date: June 2015
• Source: University of Leipzig
• Contact: n/a
• Is FDA regulated: No
• Health authority: Germany: Federal Institue for Drugs and Medicinal Devices
• Study type: Interventional

Clinical Trial Summary

Adiponectin and exercise training contribute to the maintenance of a normal vascular tone by influencing vascular NO bioavailability and concentration and function of endothelial progenitor cells. The molecular mechanisms are only partially understood. Therefore, aim of the present study is to elucidate the effects of Adiponectin on endothelial progenitor cell migration and the underlying signaling pathways. Furthermore, the impact of exercise training on adiponectin-mediated endothelial progenitor cell migration will be investigated.

Recruitment information / eligibility

• Status: Completed
• Enrollment: 20
• Est. completion date: March 2011
• Est. primary completion date: March 2011
• Accepts healthy volunteers: Accepts Healthy Volunteers
• Gender: Male
• Age group: 18 Years to 75 Years

Eligibility

Inclusion Criteria:

• = 75 years of age

• stable coronary artery disease

• preserved left ventricular function

• physical work capacity of = 50

• successful elective percutaneous coronary intervention at study begin

Exclusion Criteria:

• diabetes mellitus

• hypercholesterolemia

• untreated hypertension

• smoking

• myocardial infarction within the last 4 weeks

• significant stenosis of the left main coronary artery

Study Design

Allocation: Randomized, Endpoint Classification: Efficacy Study, Intervention Model: Parallel Assignment, Masking: Open Label, Primary Purpose: Basic Science

Related Conditions & MeSH terms

• Coronary Artery Disease
• Coronary Disease
• Myocardial Ischemia

Intervention

Other:
• exercise training
4 weeks supervised physical exercise training

Locations

Country	Name	City	State
Germany	University of Leipzig, Heart Center	Leipzig

Sponsors (3)

Lead Sponsor	Collaborator
University of Leipzig	German Research Foundation, Heartcenter Leipzig GmbH

Country where clinical trial is conducted

Germany, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	migratory capacity of endothelial progenitor cells towards an SDF-1 gradient		4 weeks	No