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Clopidogrel/Aspirin Interaction Study — INTERACTION  

Coronary Artery Disease Clinical Trial

Official title:
Randomized, Factorial Study to Explore Interaction Between Aspirin and Clopidogrel in Stable Patients With Previous Myocardial Infarction or Coronary Artery Stent

Clinical Trial Summary

This study will explore the effect of different doses of aspirin on the effects of double-dose or standard dose clopidogrel.

Clinical Trial Description

Study Hypothesis: Patients receiving double-dose compared with standard-dose clopidogrel will have increased blood concentrations of the active metabolite of clopidogrel and greater inhibition of ADP-induced platelet aggregation when also treated with acetylsalicylic acid (ASA) 325 mg/d as compared to ASA 81 mg/d. ;

Study Design

Allocation: Randomized, Endpoint Classification: Pharmacokinetics/Dynamics Study, Intervention Model: Factorial Assignment, Masking: Open Label, Primary Purpose: Treatment

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT01102439
Study type Interventional
Source Population Health Research Institute
Contact
Status Completed
Phase Phase 4
Start date April 2010
Completion date February 2013
View Details
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