Coronary Artery Disease Clinical Trial
Official title:
Strain-Encoded Cardiac Magnetic Resonance Imaging as an Adjunct for Dobutamine Stress Testing.
The purpose of this study is to compare the diagnostic value of SENC to that provided by conventional wall motion analysis for the detection of inducible ischemia during DS-MRI.High-dose dobutamine stress magnetic resonance imaging (DS-MRI) is safe and feasible for the diagnosis of coronary artery disease (CAD) in humans. However, the assessment of cine scans relies on the visual interpretation of regional wall motion, which is subjective. Recently, Strain-Encoded MRI (SENC) has been proposed for the direct color-coded visualization of myocardial strain.
The assessment of inducible regional wall motion abnormalities during high-dose dobutamine
stress magnetic resonance imaging (DS-MRI) is an established clinical method with high
diagnostic and prognostic value for the evaluation of patients with coronary artery disease
(CAD). However, the assessment of cine images relies on the visual interpretation of
regional wall motion, which is subjective, and objective approaches for the detection of
inducible ischemia with DS-MRI are still lacking.
In our study Strain-Encoded-MRI (SENC) is used for the objective color-coded evaluation of
regional myocardial strain during DS-MRI in patients with intermediate to high pretest
probability for CAD. We anticipated that this technique would exhibit enhanced sensitivity
for the detection of anatomically significant CAD compared to conventional wall motion
reading, with invasive coronary angiography used as the standard reference.
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Observational Model: Cohort, Time Perspective: Prospective
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