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NCT00730899 Clinical Trial

Association Study of Gene Polymorphisms With Cardiac Performance

Coronary Artery Disease Clinical Trial

Official title:
Observational Association Study of G Protein Polymorphisms With Cardiac Performance in Coronary Artery Disease Patients Undergoing Coronary Artery Bypass Grafting

Clinical Trial Details — Status: Recruiting

Administrative data
NCT number NCT00730899
Other study ID # HOT-001
Secondary ID
Status Recruiting
Phase N/A
First received August 4, 2008
Last updated August 4, 2008
Start date May 2008
Est. completion date June 2011

Study information
Verified date August 2008
Source University Hospital, Essen
Contact Ulrich H Frey, MD
Phone +49201723
Email ulrich.frey@uk-essen.de
Is FDA regulated No
Health authority Germany: Federal Ministry of Education and Research
Study type Observational

Clinical Trial Summary

The purpose of this study is to determine whether polymorphisms in G protein subunits, namely Galphas and Galphaq, are associated with altered cardiac performance in heart failure patients.

Description:

G Protein pathways plays a pivotal role in mediating positive inotropy and cardiac hypertrophy by transducing signals of neurohormones in cardiomyocytes. Single nucleotide polymorphisms (SNPs) in the G protein subunits Galphas and Galphaq have been shown to result in altered protein expression. We now want to examine whether G Protein polymorphisms alter NYHA functional class, and hemodynamic variables in patients with coronary artery disease scheduled for coronary artery bypass grafting .

Recruitment information / eligibility
Status Recruiting
Enrollment 500
Est. completion date June 2011
Est. primary completion date January 2011
Accepts healthy volunteers No
Gender Both
Age group 18 Years to 80 Years
Eligibility Inclusion Criteria:

- clinical diagnosis of coronary artery disease

- patients scheduled for coronary artery bypass grafting

Exclusion Criteria:

- emergency operation

- combined vitium

Study Design

Observational Model: Cohort, Time Perspective: Prospective

Related Conditions & MeSH terms

Locations
Country Name City State
Germany University Hospital Essen Nordrhein-Westfalen

Sponsors (1)
Lead Sponsor Collaborator
University Hospital, Essen

Country where clinical trial is conducted

Germany, 

Outcome
Type Measure Description Time frame Safety issue
Primary genotype dependent change of hemodynamic variables one day No
Secondary all cause mortality 60 days No
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