Coronary Artery Disease Clinical Trial
Official title:
The Effect of Acute Statin Treatment on Inflammation and Peripheral Arterial Tone in Patients Undergoing Percutaneous Coronary Intervention.
The goal of this study is to determine if one dose of simvastatin will decrease the inflammatory response to coronary intervention. Also to determine if one dose of simvastatin affects endothelial function (activity of the artery) as measured by noninvasive peripheral artery tonography.
The objective of this study is to determine if acute pretreatment with simvastatin, an
HMG-CoA reductase inhibitor will reduce the post inflammatory response after percutaneous
coronary interventions (PCI), and/or change endothelial function as assessed by peripheral
arterial tomography (PAT). Percutaneous coronary intervention (PCI), commonly known as
coronary angioplasty or simply angioplasty, is a non-surgical procedure used to treat the
stenotic (narrowed) coronary arteries of the heart found in coronary heart disease.
Patients will be pretreated with simvastatin 80 mg prior to undergoing PCI. Endothelial
function will be assessed before and after treatment via PAT. Our working hypothesis is
patients pretreated with simvastatin, will have 1) attenuated inflammatory response, as
noted by decreased levels of serum high sensitivity CRP and IL-6 and 2) improved endothelial
function as compared to patients not pretreated with statin therapy.
;
Allocation: Randomized, Endpoint Classification: Efficacy Study, Intervention Model: Parallel Assignment, Masking: Double Blind (Subject, Caregiver, Investigator, Outcomes Assessor), Primary Purpose: Treatment
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