Training at Different Intensities in Coronary Artery Disease -Effects on Myocardial Function

Coronary Artery Disease Clinical Trial

Official title:

Which Training Intensity is Most Effective in Improving Myocardial Function in Patients With Coronary Artery Disease?

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT00201591
• Other study ID #: Trehab I NTNU
• Status: Completed
• Phase: N/A
• First received: September 16, 2005
• Last updated: August 25, 2011
• Start date: August 2002
• Est. completion date: January 2004

Study information

• Verified date: August 2011
• Source: Norwegian University of Science and Technology
• Contact: n/a
• Is FDA regulated: No
• Health authority: Norway: Norwegian Social Science Data Services
• Study type: Interventional

Clinical Trial Summary

The study investigated if aerobic endurance exercise of different intensity has different impact on the physical capacity and myocardial function in patients with coronary artery disease. Patients with stable CAD trained for 10 weeks, and oxygen consumption and myocardial function were measured before and after this period. Patients were randomly assigned to each exercise group.

Description:

Peak oxygen consumption was measured by gas-analysis. Myocardial function was measured by echocardiography. Exercise was performed on treadmills under close supervision of an exercise physiologist. Patients had to complete over 70% of sessions to be included in analysis. Three sessions were scheduled every week. Heart rate (HR) was about 85 % of max HR in the high intensity group, and about 65 % in the moderate intensity group.

Recruitment information / eligibility

• Status: Completed
• Enrollment: 17
• Est. completion date: January 2004
• Est. primary completion date: January 2004
• Accepts healthy volunteers: No
• Gender: Both
• Age group: 20 Years to 80 Years

Eligibility

Inclusion Criteria:

• stable coronary artery disease

• over 4 months since cardiovascular event

Exclusion Criteria:

• heart failure

• inability to exercise

Study Design

Allocation: Randomized, Endpoint Classification: Efficacy Study, Intervention Model: Parallel Assignment, Masking: Open Label, Primary Purpose: Treatment

Related Conditions & MeSH terms

• Coronary Artery Disease
• Coronary Disease
• Myocardial Ischemia

Intervention

Behavioral:
• Exercise training for 10 weeks

Locations

Country	Name	City	State
Norway	Dept. of Circulation and Medical Imaging, NTNU	Trondheim

Sponsors (2)

Lead Sponsor	Collaborator
Norwegian University of Science and Technology	St. Olavs Hospital

Country where clinical trial is conducted

Norway, 

References & Publications (1)

Amundsen BH, Rognmo Ø, Hatlen-Rebhan G, Slørdahl SA. High-intensity aerobic exercise improves diastolic function in coronary artery disease. Scand Cardiovasc J. 2008 Apr;42(2):110-7. doi: 10.1080/14017430701744477. — View Citation

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Peak oxygen consumption
Secondary	Quality of life
Secondary	Myocardial function measured by echocardiography