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Corneal Edema clinical trials

View clinical trials related to Corneal Edema.

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NCT ID: NCT06261346 Not yet recruiting - Clinical trials for Fuchs' Endothelial Dystrophy

Plasma Rich in Growth Factors in Corneal Endothelial Transplantation

Start date: February 20, 2024
Phase: N/A
Study type: Interventional

The purpose of the study is to determine the safety and efficacy of brief intraoperative corneal endothelial graft incubation in plasma rich in growth factors (PRGF) for reducing postoperative endothelial cell loss. Subjects scheduled for endothelial keratoplasty will be enrolled and randomized to have the graft incubated in PRGF or not prior to graft implantation. The main outcome is the percentage central corneal endothelial cell loss 6 months after surgery.

NCT ID: NCT06041256 Recruiting - Corneal Edema Clinical Trials

A Phase 1/2 Study of AURN001 in Subjects With Corneal Edema Secondary to Corneal Endothelial Dysfunction (ABA-1)

CLARA
Start date: October 18, 2023
Phase: Phase 1/Phase 2
Study type: Interventional

The goal of this clinical trial is to compare different doses of AURN001 in patients with corneal edema secondary to corneal endothelial dysfunction. The main questions the clinical trial aims to answer are whether AURN001 effective and safe. Participants will receive a single injection of AURN001. A comparison between low, medium, and high doses of AURN001 against the contribution of each element, cells alone and Y27632 alone, will be conducted to determine the effects on corneal edema.

NCT ID: NCT05956535 Enrolling by invitation - Corneal Edema Clinical Trials

Air Optix® Night and Day® Aqua Therapeutic Wear

Start date: September 26, 2023
Phase:
Study type: Observational

The purpose of this study is to support the safety and performance assessment of Air Optix Night and Day Aqua (AONDA) soft contact lenses for therapeutic use in accordance with updated EU Medical Device Regulation (MDR) requirements.

NCT ID: NCT05891106 Completed - Corneal Ulcer Clinical Trials

AONDA Therapeutic Indication Study I

Start date: June 28, 2023
Phase:
Study type: Observational

This study will be used to support assessment of AIR OPTIX® NIGHT & DAY® AQUA (AONDA) Soft Contact Lenses' safety and performance in accordance with updated European Union Medical Device Regulation (EU MDR) requirements.

NCT ID: NCT05636579 Recruiting - Clinical trials for Endothelial Dysfunction

Study to Assess Safety and Tolerability of Multiple Doses of EO2002

Start date: December 1, 2022
Phase: Phase 1
Study type: Interventional

The goal of this clinical study is to assess the safety of multiple intracameral injections of EO2002 with and without topical Ripasudil.

NCT ID: NCT05626478 Recruiting - Corneal Edema Clinical Trials

Assessing eFficacy and Safety of DEXTENZA 0.4 mg inseRt, Following Cataract Surgery

Start date: June 1, 2023
Phase: Phase 4
Study type: Interventional

Assessing eFficacy and Safety of DEXTENZA 0.4 mg inseRt, Following Cataract Surgery

NCT ID: NCT05528172 Completed - Clinical trials for Corneal Edema After Cataract Surgery

A Study to Investigate the Safety and Efficacy of Ripasudil (K-321) Eye Drops After Cataract Surgery

Start date: August 4, 2022
Phase: Phase 3
Study type: Interventional

The purpose of this study is to assess the safety and efficacy of K-321 in subjects after cataract surgery

NCT ID: NCT05436665 Recruiting - Clinical trials for Fuchs' Endothelial Dystrophy

The Belgian Endothelial Surgical Transplant of the Cornea

BESTCornea
Start date: August 10, 2022
Phase: N/A
Study type: Interventional

This study is designed as a randomised multicentric parallel group pragmatic trial of Descemet Stripping Automated Endothelial Keratoplasty (DSAEK) versus Descemet Membrane Endothelial Keratoplasty (DMEK) in corneal endothelial decompensation. the purpose is to compare the clinical and patient reported outcomes of both therapies across a broad range of indications.

NCT ID: NCT05309135 Completed - Corneal Edema Clinical Trials

A Safety and Efficacy Study of Corneal Injection for Endothelial Dysfunction Using Human Corneal Endothelial Cell Therapy in Subjects With Corneal Edema Secondary to Endothelial Dysfunction

Escalon
Start date: March 24, 2022
Phase: Phase 1
Study type: Interventional

The purpose of this study is to assess the safety of a fixed dose of human corneal endothelial cells when administered with varying concentrations of Rho kinase inhibitor (Y-27632) in patients with corneal edema secondary to endothelial dysfunction.

NCT ID: NCT05271058 Completed - Corneal Edema Clinical Trials

Effect of Intracameral Steroids During Phacoemulsification on the Cornea

Start date: June 16, 2019
Phase: Phase 3
Study type: Interventional

Prospective, interventional case control study. Sixty-nine eyes were randomized into 3 groups, 23 eyes each : 2groups received intracameral dexamethasone and triamcinolone (TA) respectively, while controls didn't receive any intraoperative steroids. Intracameral steroids at the conclusion of phacoemulsification significantly improved corneal edema and spared corneal endothelium.