Plasma Rich in Growth Factors in Corneal Endothelial Transplantation

Status Not yet recruiting

Clinical Trial Summary

The purpose of the study is to determine the safety and efficacy of brief intraoperative corneal endothelial graft incubation in plasma rich in growth factors (PRGF) for reducing postoperative endothelial cell loss. Subjects scheduled for endothelial keratoplasty will be enrolled and randomized to have the graft incubated in PRGF or not prior to graft implantation. The main outcome is the percentage central corneal endothelial cell loss 6 months after surgery.

Clinical Trial Description

n/a

Study Design

Related Conditions & MeSH terms

Clinical Trial Details

NCT number	NCT06261346
Study type	Interventional
Source	Price Vision Group
Contact	Marianne Price, PhD
Phone	317-814-2990
Email	mprice@cornea.org
Status	Not yet recruiting
Phase	N/A
Start date	May 15, 2024
Completion date	June 30, 2026

View Details

See also
Status	Clinical Trial	Phase
Completed	`NCT03248037` - Trial of Netarsudil for Prevention of Corticosteroid-induced Intraocular Pressure Elevation	Phase 3
Recruiting	`NCT03275896` - Evaluation of the Efficacy of Descemet Membrane Transplantation for the Treatment of Fuchs' Endothelial Dystrophy	Early Phase 1
Completed	`NCT02332109` - ODM 5 in the Treatment of Corneal Edematous Fuchs' Endothelial Dystrophy	N/A
Completed	`NCT02470793` - Technique And Results In Endothelial Keratoplasty	N/A
Recruiting	`NCT01206127` - DSAEK- Postoperative Positioning and Transplant Dislocation	N/A
Recruiting	`NCT03407755` - Air Versus SF6 for Descemet's Membrane Endothelial Keratoplasty (DMEK)	N/A
Completed	`NCT04140422` - Eye Drops for Early Morning-Associated Corneal Swelling of the Cornea	N/A
Recruiting	`NCT06048380` - The Effects of Ripasudil in Patients With FED Undergoing Femtosecond Laser Assisted Cataract Surgery	Phase 3
Completed	`NCT02793310` - DMEK Versus DSAEK Study	N/A
Completed	`NCT01795001` - The Molecular Pathogenesis of Late-onset Fuchs' Endothelial Corneal Dystrophy
Completed	`NCT04057053` - Netarsudil Use After Descemetorhexis Without Endothelial Keratoplasty	Early Phase 1
Terminated	`NCT01361282` - Using the Optovue OCT to Select IOL Power	N/A
Completed	`NCT02542644` - Assessment of Corneal Graft Attachment in Patients With Fuchs Endothelial Corneal Dystrophy Following DMEK Using Ultra-high Resolution OCT	N/A
Recruiting	`NCT04191629` - Phase 1 Study to Evaluate the Safety and Tolerability of EO1404 in the Treatment of Corneal Edema	Phase 1
Completed	`NCT05399095` - Supine Positioning for Graft Attachment After Descemet Membrane Endothelial Keratoplasty	N/A
Completed	`NCT04752020` - Netarsudil Use After Descemtorhexis Without Endothelial Keratoplasty	Early Phase 1
Not yet recruiting	`NCT05716945` - The OPTIMISE Study	Phase 4
Recruiting	`NCT03575130` - Ripasudil 0.4% Eye Drops in Fuchs Endothelial Corneal Dystrophy	Phase 2
Recruiting	`NCT02118922` - A Study to Test the Diagnostic Potential of Brillouin Microscopy for Corneal Ectasia
Completed	`NCT04420429` - The Effect Of Preoperative Parameters On Success After DMEK Surgery