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NCT02051296 Clinical Trial

Minocycline to Reduce Pain After Carpal Tunnel Release

Chronic Pain Clinical Trial

Official title:
A Trial of Minocycline for Pain After Carpal Tunnel and Trigger Release

Clinical Trial Details — Status: Completed

Administrative data
NCT number NCT02051296
Other study ID # RX000487
Secondary ID
Status Completed
Phase Phase 2
First received
Last updated
Start date January 2012
Est. completion date April 2014

Study information
Verified date May 2018
Source VA Palo Alto Health Care System
Contact n/a
Is FDA regulated No
Health authority
Study type Interventional

Clinical Trial Summary

The investigators are looking at whether peri-operative minocycline will reduce the duration of pain after minor hand surgery: carpal tunnel release and trigger finger release.

The investigators' hypothesis is that minocycline will reduce post-operative pain.

Description:

This is a double blinded randomized controlled trial. Patients are given 100mg of minocycline 2 hours prior to their procedure and then 100mg two times a day for 5 days. The subjects are then contacted daily to check their level of pain. The investigators' outcome of interest is time to pain resolution.

The investigators will perform a futility analysis to assess if a larger trial would be a reasonable next step after this pilot study.

Recruitment information / eligibility
Status Completed
Enrollment 131
Est. completion date April 2014
Est. primary completion date April 2014
Accepts healthy volunteers Accepts Healthy Volunteers
Gender All
Age group 18 Years and older
Eligibility Inclusion Criteria:

- Adult, Veteran,

Exclusion Criteria:

- Kidney failure, Liver failure, thrombocytopenia, ALS, SLE, Frailty, unable to understand survery

Study Design

Related Conditions & MeSH terms

Intervention

Drug:
• Minocycline
RCT blinded placebo trial
• placebo
RCT blinded placebo trial

Locations
Country Name City State
United States Palo Alto VA Palo Alto California

Sponsors (2)
Lead Sponsor Collaborator
VA Palo Alto Health Care System Stanford University

Country where clinical trial is conducted

United States, 

Outcome
Type Measure Description Time frame Safety issue
Primary Time to Pain Resolution the time until patient answers no pain at surgical site for three consecutive days up to 365 days
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