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Chronic Pain clinical trials

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NCT ID: NCT06247852 Recruiting - Chronic Pain Clinical Trials

Persistent Pain After Cesarean Delivery - A Danish Multicenter Cohort Study

Start date: September 1, 2023
Phase:
Study type: Observational

In Denmark, around 12,700 patients undergo Cesarean delivery (CD) annually, constituting approximately 20% of all childbirths in the country. Worldwide, the number is increasing each year, with more than 20 million CD performed annually. Postoperative pain after CD is typically moderate to severe in intensity and still constitutes a significant challenge, balancing effective pain relief and potential side effects. Correlations between moderate to severe acute pain and the development of persistent pain after CD is still unclear. Postsurgical persistent pain is a significant, often unrecognized clinical problem that causes distress and diminishes the quality of life for patients. Despite advances in understanding the factors contributing to persistent postsurgical pain and an increased focus on identifying patients at risk, the management and prevention of postsurgical persistent pain are still inadequate. It is important to gain further insights into this population, and we have a unique opportunity to do so by following the national cohort from the ongoing Danish multicenter cohort study on pain after cesarean section (ClinicalTrials.gov Identifier: NCT06012747) over an extended follow-up period. This involves continued prospective registration of Patient-Reported Outcome Measures (PROM) collected by SMS-based questionnaires in the months and years after the CD, thereby investigating the occurrence of both acute and persistent pain after CD. The outcomes are focused on pain levels, the impact of pain on physical function and neuropathic pain characteristics in the months and years following the CD. The study also aims to explore the relationship between persistent and acute pain.

NCT ID: NCT06247813 Recruiting - Chronic Pain Clinical Trials

Pilot Study: Impact of Biomarker-Guided Dietary Supplementation on Quality-of-Life Measures in Subjects With Chronic Pain

Start date: February 1, 2024
Phase: Phase 2
Study type: Interventional

The goal of this study is to use pain-specific urine biomarkers to evaluate how daily nutritional supplementation with biomarker guided formulas effect, quality of life and urinary biomarker scores in chronic pain patients. Assessing the effect of biomarker guided supplementation on pain specific biomarkers through changes in urinary biomarker scores may solidify the necessity for identifying deficiencies to create an individualized treatment plan for pain patients. This study aims to evaluate the effect of biomarker-guided supplementation on the three categories of urinary biomarkers using targeted ingredients specifically designed for oxidative stress, inflammation, and nerve health. This study provides subjects with one of three nutritional supplement formulas based on their specific urinary biomarker test results and assesses changes in their urinary biomarker levels and their quality of life as it relates to their pain over a 3-month period.

NCT ID: NCT06246526 Recruiting - Pain Clinical Trials

Real-World Efficacy of Evoke® Closed-loop Spinal Cord Stimulation (CL-SCS) Therapy in Chronic Pain Patients (ULTRA).

Start date: January 30, 2024
Phase: N/A
Study type: Interventional

This observational, prospective data collection is designed to evaluate the efficacy of CL-SCS therapy in real-world patients suffering from chronic pain.

NCT ID: NCT06245226 Recruiting - Chronic Pain Clinical Trials

Assessment of Posture, Balance, Gait Disorders in Patients With Fibromyalgia

Start date: October 15, 2023
Phase:
Study type: Observational

The study aims to determine the posture, balance and gait disorders objectively in patients with fibromyalgia (FM) and to investigate their relationships with disease-related parameters.

NCT ID: NCT06244602 Recruiting - Clinical trials for Chronic Non-Cancer Pain

Test-retest and Experiences During Balance Assessment With the Mini-BESTest

Start date: February 14, 2024
Phase:
Study type: Observational

The goal of this observational study is to test psychometric properties of a clinical balance assessment scale, the Mini-BESTest, as well as to explore experiences and beliefs about balance and being balance tested. The main research questions are: - What is the test-retest reliability of the Mini-BESTest balance assessment scale for individuals with long-term pain? - What is the individual's subjective beliefs and experiences about their own balance and being balance tested with the Mini-BESTest? Tow samples of participants will be included. One sample for a) the test-retest evaluation or b) an interview during and after performing the Mini-BESTest.

NCT ID: NCT06243835 Recruiting - Chronic Pain Clinical Trials

A Study to Test the Effects of Kindolor at Different Doses in Healthy Adults

Start date: April 21, 2024
Phase: Phase 1
Study type: Interventional

The goal of this study is to test Kindolor in healthy adults. The main questions it aims to answer are: - What is the safe dose of Kindolor in healthy volunteers? - How is Kindolor metabolized by the human body? Participants will undergo medical tests before and after receiving Kindolor or a placebo to see if there is any difference between the groups.

NCT ID: NCT06229470 Recruiting - Chronic Pain Clinical Trials

Clinical Utility of Neurophysiological Measurements of ECAP-controlled Closed-loop SCS to Guide Treatment of Chronic Pain

Neural Panel
Start date: March 8, 2024
Phase: N/A
Study type: Interventional

The purpose of this study is to evaluate the clinical utility of neurophysiological measurements of ECAP-controlled closed-loop SCS (i.e., neural panel metrics) to guide treatment of chronic pain of the trunk and/or limbs.

NCT ID: NCT06222151 Recruiting - Physical Activity Clinical Trials

Recovering From Bariatric Surgery: the Effects of Early Initiated and Supervised Mobilization

Start date: April 22, 2024
Phase: N/A
Study type: Interventional

The aim is to investigate the effect of early initiated and supervised mobilization continued after discharge as management of postoperative pain and recovery following obesity surgery, including patient experiences, pain coping, physical functionality and quality of life.

NCT ID: NCT06218784 Recruiting - Pain Clinical Trials

A MAD Study to Evaluate the Safety, Tolerability and PK/PD of iN1011-N17 in Healthy Volunteers and PHN Patients.

Start date: November 11, 2022
Phase: Phase 1
Study type: Interventional

This study is a 3-part, Double-blind, Randomized, Placebo-controlled, Multiple Ascending Dose Study to Evaluate Safety, Tolerability, Pharmacokinetics/Pharmacodynamic properties of iN1011-N17 after Oral Administration in Healthy Volunteers and Post-Herpetic Neuralgia patients, and to assess the relative bioavailability of Mesylate vs Hydrochloride salt capsules of iN1011-N17 in Healthy volunteers.

NCT ID: NCT06214923 Recruiting - Pain Clinical Trials

Neural Mechanisms of Immersive Virtual Reality in Chronic Pain (VR TMD EEG)

VR TMD EEG
Start date: April 9, 2024
Phase: N/A
Study type: Interventional

This project examines, in chronic pain, the mechanisms of immersive virtual reality compared to the mechanisms of placebo hypoalgesia. The potential of developing new non-pharmacological premises for low-risk interventions for pain management is high.